Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Long-range signaling in growing neurons after local elevation of cyclic AMP-dependent activity.
Zheng JQ
,
Zheng Z
,
Poo M
.
???displayArticle.abstract???
Cyclic AMP-dependent activity at the growth cone or the soma of cultured Xenopus spinal neurons was elevated by local extracellular perfusion of the neuron with culture medium containing 8-bromoadenosine 3',5'-cyclic monophosphate (8-br-cAMP) or forskolin. During local perfusion of one of the growth cones of multipolar neurons with these drugs, the perfused growth cone showed further extension, while the distant, unperfused growth cones were inhibited in their growth. Local perfusion of the growth cone with culture medium or local perfusion with 8-br-cAMP at a cell-free region 100 microns away from the growth cone did not produce any effect on the extension of the growth cone. Reduced extension of all growth cones was observed when the perfusion with 8-br-cAMP was restricted to the soma. The distant inhibitory effect does not depend on the growth of the perfused growth cone since local coperfusion of the growth cone with 8-br-cAMP and colchicine inhibited growth on both perfused and unperfused growth cones, while local perfusion with colchicine alone inhibited only the perfused growth cone. The distant inhibitory effect was abolished when the perfusion of 8-br-cAMP was carried out together with kinase inhibitor H-8, suggesting the involvement of cAMP-dependent protein kinase and/or its downstream factors in the long-range inhibitory signaling. Uniform exposure of the entire neuron to bath-applied 8-br-cAMP, however, led to enhanced growth activity at all growth cones. Thus, local elevation of cAMP-dependent activity produces long-range and opposite effects on distant parts of the neuron, and a cytosolic gradient of second messengers may produce effects distinctly different from those following uniform global elevation of the messenger, leading to differential growth regulation at different regions of the same neuron.
Anderson,
Effects of innervation on the distribution of acetylcholine receptors on cultured muscle cells.
1977, Pubmed,
Xenbase
Anderson,
Effects of innervation on the distribution of acetylcholine receptors on cultured muscle cells.
1977,
Pubmed
,
Xenbase
Azhderian,
Cyclic AMP modulates fast axonal transport in Aplysia bag cell neurons by increasing the probability of single organelle movement.
1994,
Pubmed
Baptista,
Modulation of the pattern of axonal projections of a leech motor neuron by ablation or transplantation of its target.
1988,
Pubmed
Bray,
Growth cone motility and guidance.
1988,
Pubmed
Clark,
Induction of long-term facilitation in Aplysia sensory neurons by local application of serotonin to remote synapses.
1993,
Pubmed
Connolly,
Rapid regulation of neuronal growth cone shape and surface morphology by nerve growth factor.
1987,
Pubmed
Dan,
Retrograde interactions during formation and elimination of neuromuscular synapses.
1994,
Pubmed
Forscher,
Cyclic AMP induces changes in distribution and transport of organelles within growth cones of Aplysia bag cell neurons.
1987,
Pubmed
Gao,
Axon extension and retraction by leech neurons: severing early projections to peripheral targets prevents normal retraction of other projections.
1988,
Pubmed
Goldberg,
Differential growth of the branches of a regenerating bifurcate axon is associated with differential axonal transport of organelles.
1987,
Pubmed
Goslin,
Experimental observations on the development of polarity by hippocampal neurons in culture.
1989,
Pubmed
Hagiwara,
Specific binding of a novel compound, N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide (H-8) to the active site of cAMP-dependent protein kinase.
1987,
Pubmed
Harish,
Retrograde modulation at developing neuromuscular synapses: involvement of G protein and arachidonic acid cascade.
1992,
Pubmed
,
Xenbase
Heidemann,
Synergistic effects of cyclic AMP and nerve growth factor on neurite outgrowth and microtubule stability of PC12 cells.
1985,
Pubmed
Laurenza,
Stimulation of adenylate cyclase by water-soluble analogues of forskolin.
1987,
Pubmed
Lohof,
Asymmetric modulation of cytosolic cAMP activity induces growth cone turning.
1992,
Pubmed
,
Xenbase
Mattson,
Neurite outgrowth in individual neurons of a neuronal population is differentially regulated by calcium and cyclic AMP.
1988,
Pubmed
Muneyama,
Chemical synthesis and biological activity of 8-substituted adenosine 3',5'-cyclic monophosphate derivatives.
1971,
Pubmed
Popov,
Diffusional transport of macromolecules in developing nerve processes.
1992,
Pubmed
,
Xenbase
Richter-Landsberg,
The role of cAMP in nerve growth factor-promoted neurite outgrowth in PC12 cells.
1986,
Pubmed
Rydel,
cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor.
1988,
Pubmed
Salmon,
Rapid rate of tubulin dissociation from microtubules in the mitotic spindle in vivo measured by blocking polymerization with colchicine.
1984,
Pubmed
Seeley,
Short-latency local actions of nerve growth factor at the growth cone.
1983,
Pubmed
Smalheiser,
The possible role of "sibling neurite bias" in the coordination of neurite extension, branching, and survival.
1984,
Pubmed
Spitzer,
The development of the action potential mechanism of amphibian neurons isolated in culture.
1976,
Pubmed
,
Xenbase