XB-ART-17451
Nature
1996 Nov 07;3846604:78-80. doi: 10.1038/384078a0.
Show Gene links
Show Anatomy links
K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current.
???displayArticle.abstract???
In mammalian cardiac cells, a variety of transient or sustained K+ currents contribute to the repolarization of action potentials. There are two main components of the delayed-rectifier sustained K+ current, I(Kr) (rapid) and I(Ks), (slow). I(Kr) is the product of the gene HERG, which is altered in the long-QT syndrome, LQT2. A channel with properties similar to those of the I(Ks) channel is produced when the cardiac protein IsK is expressed in Xenopus oocytes. However, it is a small protein with a very unusual structure for a cation channel. The LQT1 gene is another gene associated with the LQT syndrome, a disorder that causes sudden death from ventricular arrhythmias. Here we report the cloning of the full-length mouse K(V)LQT1 complementary DNA and show that K(V)LQT1 associates with IsK to form the channel underlying the I(Ks) cardiac current, which is a target of class-III anti-arrhythmic drugs and is involved in the LQT1 syndrome.
???displayArticle.pubmedLink??? 8900282
???displayArticle.link??? Nature
Species referenced: Xenopus
Genes referenced: arfgap1 kcne1 kcnh2 mink1
References :
Attali,
Ion channels. A new wave for heart rhythms.
1996, Pubmed