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XB-ART-32285
Nature 1977 Mar 17;2665599:235-9.
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5'-Terminal structure and mRNA stability.

Furuichi Y , LaFiandra A , Shatkin AJ .


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Reovirus mRNAs with 5'terminal m7GpppGm or GpppG are more stable than mRNA containing unblocked ppG 5'-ends when injected into Xenopus laevis oocytes or incubated in cell-free protein synthesising extracts of wheat germ and mouse L cells. The greater stability of mRNA with blocked 5' termini is not dependent upon translation but seems to result from protection against 5'-exonucleolytic degradation.

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