Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-25432
Neuron 1990 Dec 01;56:767-71.
Show Gene links Show Anatomy links

Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor.

MacKinnon R , Heginbotham L , Abramson T .


???displayArticle.abstract???
The Shaker K+ channel belongs to a family of structurally related voltage-activated cation channels that play a central role in cellular electrical signaling. By studying multiple site-directed mutants of the Shaker K+ channel, a region that forms the binding site for a pore-blocking scorpion toxin has been identified. The region contains a sequence that is highly conserved among cloned K+ channels and may contribute to the formation of the ion conduction pore.

???displayArticle.pubmedLink??? 1702643
???displayArticle.link??? Neuron
???displayArticle.grants??? [+]