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XB-ART-10510
Mech Dev 2000 Aug 01;961:129-32. doi: 10.1016/s0925-4773(00)00383-x.
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The biphasic expression of IMP/Vg1-RBP is conserved between vertebrates and Drosophila.

Nielsen J , Cilius Nielsen F , Kragh Jakobsen R , Christiansen J .


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The human IGF-II mRNA-binding proteins (IMPs) 1-3, and their Xenopus homologue Vg1 RNA-binding protein (Vg1-RBP) are RNA-binding proteins implicated in mRNA localization and translational control in vertebrate development. We have sequenced the Drosophila homologue (dIMP) of these genes, and examined its expression pattern in Drosophila embryos by in situ hybridization. The study shows that dIMP exhibits a biphasic expression pattern. In the early stages of development, a maternal pool of dIMP mRNA is evenly distributed in the embryo and degraded by the end of stage 4. Expression reappears in the developing central nervous system, where dIMP is expressed throughout neurogenesis. In addition, dIMP is present in the pole cells.

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Species referenced: Xenopus
Genes referenced: brap gdf1 igf2bp3 impdh1