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XB-ART-30677
Proc Natl Acad Sci U S A 1982 May 01;799:3052-6.
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Cyclic GMP mimics the muscarinic response in Xenopus oocytes: identity of ionic mechanisms.

Dascal N , Landau EM .


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Acetylcholine (AcCho) elicits four distinct membrane responses in Xenopus oocytes; the responses can be studied by using the voltage clamp technique. The fastest of the responses, a transient inward current (D1 response), is muscarinic, being evoked by oxotremorine and blocked by atropine but not by curare or hexamethonium. The action of AcCho is cooperative, three transmitter-receptor complexes being required to cause a membrane conductance change, and the dose-response curve in most cases can be fitted by an equation assuming the existence of two binding sites with an affinity ratio of about 11. Guanosine 3',5'-cyclic monophosphate and the 8-bromo and dibutyryl derivatives cause a response similar to D1 in both its time course and the underlying ionic mechanism. The nucleotide-generated response has a smaller amplitude than the AcCho-generated D1.

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References [+] :
Anderson, Voltage clamp analysis of acetylcholine produced end-plate current fluctuations at frog neuromuscular junction. 1973, Pubmed