Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-22580
Nature 1993 May 27;3636427:350-3. doi: 10.1038/363350a0.
Show Gene links Show Anatomy links

Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF.

Lohof AM , Ip NY , Poo MM .


???displayArticle.abstract???
The neurotrophins are a family of neurotrophic factors that promote survival and differentiation of various neuronal populations. Although the long-term effects of neurotrophins on neuronal survival and differentiation have been intensively studied, nothing is known about their effects on synaptic function. Here we report that acute exposure to neurotrophin-3 (NT-3) or brain-derived neurotrophic factor (BDNF), but not nerve growth factor (NGF), rapidly potentiates the spontaneous and impulse-evoked synaptic activity of developing neuromuscular synapses in culture. The effect appears to be presynaptic in origin and to be mediated by the Trk family of receptor tyrosine kinases. These results provide evidence for the regulation of the function of developing synapses by neurotrophins.

???displayArticle.pubmedLink??? 8497318
???displayArticle.link??? Nature


Species referenced: Xenopus
Genes referenced: bdnf ngf ntf3