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Proc Natl Acad Sci U S A
2003 Nov 11;10023:13644-9. doi: 10.1073/pnas.2233464100.
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Pannexins, a family of gap junction proteins expressed in brain.
Bruzzone R
,
Hormuzdi SG
,
Barbe MT
,
Herb A
,
Monyer H
.
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Database search has led to the identification of a family of proteins, the pannexins, which share some structural features with the gap junction forming proteins of invertebrates and vertebrates. The function of these proteins has remained unclear so far. To test the possibility that pannexins underlie electrical communication in the brain, we have investigated their tissue distribution and functional properties. Here, we show that two of these genes, pannexin 1 (Px1) and Px2, are abundantly expressed in the CNS. In many neuronal cell populations, including hippocampus, olfactory bulb, cortex and cerebellum, there is coexpression of both pannexins, whereas in other brain regions, e.g., white matter, only Px1-positive cells were found. On expression in Xenopus oocytes, Px1, but not Px2 forms functional hemichannels. Coinjection of both pannexin RNAs results in hemichannels with functional properties that are different from those formed by Px1 only. In paired oocytes, Px1, alone and in combination with Px2, induces the formation of intercellular channels. The functional characteristics of homomeric Px1 versus heteromeric Px1/Px2 channels and the different expression patterns of Px1 and Px2 in the brain indicate that pannexins form cell type-specific gap junctions with distinct properties that may subserve different functions.
Al-Ubaidi,
Functional properties, developmental regulation, and chromosomal localization of murine connexin36, a gap-junctional protein expressed preferentially in retina and brain.
2000, Pubmed,
Xenbase
Al-Ubaidi,
Functional properties, developmental regulation, and chromosomal localization of murine connexin36, a gap-junctional protein expressed preferentially in retina and brain.
2000,
Pubmed
,
Xenbase
Barrio,
Gap junctions formed by connexins 26 and 32 alone and in combination are differently affected by applied voltage.
1991,
Pubmed
,
Xenbase
Beierlein,
A network of electrically coupled interneurons drives synchronized inhibition in neocortex.
2000,
Pubmed
Bennett,
Electrical synapses, a personal perspective (or history).
2000,
Pubmed
Blatow,
A novel network of multipolar bursting interneurons generates theta frequency oscillations in neocortex.
2003,
Pubmed
Bruzzone,
Functional analysis of a dominant mutation of human connexin26 associated with nonsyndromic deafness.
2001,
Pubmed
,
Xenbase
Bruzzone,
Connections with connexins: the molecular basis of direct intercellular signaling.
1996,
Pubmed
Buhl,
Selective impairment of hippocampal gamma oscillations in connexin-36 knock-out mouse in vivo.
2003,
Pubmed
Condorelli,
Expression of Cx36 in mammalian neurons.
2000,
Pubmed
Deans,
Synchronous activity of inhibitory networks in neocortex requires electrical synapses containing connexin36.
2001,
Pubmed
Deans,
Connexin36 is essential for transmission of rod-mediated visual signals in the mammalian retina.
2002,
Pubmed
Draguhn,
Electrical coupling underlies high-frequency oscillations in the hippocampus in vitro.
1998,
Pubmed
Ebihara,
Cloning and expression of a Xenopus embryonic gap junction protein.
1989,
Pubmed
,
Xenbase
Ernsberger,
The developmental expression of choline acetyltransferase (ChAT) and the neuropeptide VIP in chick sympathetic neurons: evidence for different regulatory events in cholinergic differentiation.
1997,
Pubmed
Galarreta,
Electrical synapses between GABA-releasing interneurons.
2001,
Pubmed
Galarreta,
A network of fast-spiking cells in the neocortex connected by electrical synapses.
1999,
Pubmed
Gibson,
Two networks of electrically coupled inhibitory neurons in neocortex.
1999,
Pubmed
Groves,
Glycophorin A facilitates the expression of human band 3-mediated anion transport in Xenopus oocytes.
1992,
Pubmed
,
Xenbase
Güldenagel,
Visual transmission deficits in mice with targeted disruption of the gap junction gene connexin36.
2001,
Pubmed
Hormuzdi,
Impaired electrical signaling disrupts gamma frequency oscillations in connexin 36-deficient mice.
2001,
Pubmed
Johnston,
Voltage independence of an electrotonic synapse.
1982,
Pubmed
Katsumaru,
Gap junctions on GABAergic neurons containing the calcium-binding protein parvalbumin in the rat hippocampus (CA1 region).
1988,
Pubmed
Kelmanson,
Altering electrical connections in the nervous system of the pteropod mollusc Clione limacina by neuronal injections of gap junction mRNA.
2002,
Pubmed
Landisman,
Electrical synapses in the thalamic reticular nucleus.
2002,
Pubmed
Long,
Rhythmicity without synchrony in the electrically uncoupled inferior olive.
2002,
Pubmed
McBain,
Interneurons unbound.
2001,
Pubmed
Meyer,
In vivo labeling of parvalbumin-positive interneurons and analysis of electrical coupling in identified neurons.
2002,
Pubmed
Panchin,
A ubiquitous family of putative gap junction molecules.
2000,
Pubmed
Paul,
Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes.
1991,
Pubmed
,
Xenbase
Phelan,
Innexins get into the gap.
2001,
Pubmed
Schmitz,
Axo-axonal coupling. a novel mechanism for ultrafast neuronal communication.
2001,
Pubmed
Srinivas,
Functional properties of channels formed by the neuronal gap junction protein connexin36.
1999,
Pubmed
Stebbings,
Two Drosophila innexins are expressed in overlapping domains and cooperate to form gap-junction channels.
2000,
Pubmed
,
Xenbase
Tamás,
Proximally targeted GABAergic synapses and gap junctions synchronize cortical interneurons.
2000,
Pubmed
Traub,
A model of high-frequency ripples in the hippocampus based on synaptic coupling plus axon-axon gap junctions between pyramidal neurons.
2000,
Pubmed
Traub,
Contrasting roles of axonal (pyramidal cell) and dendritic (interneuron) electrical coupling in the generation of neuronal network oscillations.
2003,
Pubmed
Traub,
Synaptic and nonsynaptic contributions to giant ipsps and ectopic spikes induced by 4-aminopyridine in the hippocampus in vitro.
2001,
Pubmed
Venance,
Connexin expression in electrically coupled postnatal rat brain neurons.
2000,
Pubmed
Verselis,
A voltage-dependent gap junction in Drosophila melanogaster.
1991,
Pubmed
White,
Virtual cloning, functional expression, and gating analysis of human connexin31.9.
2002,
Pubmed
,
Xenbase
White,
Functional characteristics of skate connexin35, a member of the gamma subfamily of connexins expressed in the vertebrate retina.
1999,
Pubmed
,
Xenbase
Willecke,
Structural and functional diversity of connexin genes in the mouse and human genome.
2002,
Pubmed
Wisden,
In situ hybridization with oligonucleotide probes.
2002,
Pubmed
Ylinen,
Sharp wave-associated high-frequency oscillation (200 Hz) in the intact hippocampus: network and intracellular mechanisms.
1995,
Pubmed
