XB-ART-4505
Mol Cell
2003 Oct 01;124:797-9. doi: 10.1016/s1097-2765(03)00405-2.
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Aurora A on the mitotic spindle is activated by the way it holds its partner.
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An exciting study in this issue reveals how binding of the microtubule associated protein TPX2 to the mitotic kinase Aurora A induces a conformational change. This moves the phosphorylated activation domain into a more compact position within the kinase core, providing a better substrate binding platform and hiding the activating phosphoryl group from attack by PP1.
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Species referenced: Xenopus
Genes referenced: aurka npy4r ran tpx2
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References :
Bayliss,
Structural basis of Aurora-A activation by TPX2 at the mitotic spindle.
2003, Pubmed,
Xenbase