XB-ART-44852
J Biol Chem
2011 Dec 09;28649:41905-41911. doi: 10.1074/jbc.R111.299768.
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Metalloproteinases in Drosophila to humans that are central players in developmental processes.
Muir A
,
Greenspan DS
.
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Many secreted proteins are synthesized as precursors with propeptides that must be cleaved to yield the mature functional form of the molecule. In addition, various growth factors occur in extracellular latent complexes with protein antagonists and are activated upon cleavage of such antagonists. Research in the separate fields of embryonic patterning and extracellular matrix formation has identified members of the BMP1/Tolloid-like family of metalloproteinases as key players in these types of biosynthetic processing events in species ranging from Drosophila to humans.
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AR53815 NIAMS NIH HHS , R01 AR047746 NIAMS NIH HHS , R01 AR053815 NIAMS NIH HHS , T32 GM007133 NIGMS NIH HHS
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