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The functional properties of neural circuits become increasingly robust over development. This allows circuits to optimize their output in response to a variety of input. However, it is not clear whether this optimization is a function of hardwired circuit elements, or whether it requires neural experience to develop. We performed rapid in vivo imaging of calcium signals from bulk-labeled neurons in the Xenopus laevis optic tectum to resolve the rapid spatiotemporal response properties of populations of developing tectal neurons in response to visual stimuli. We found that during a critical time in tectal development, network activity becomes increasingly robust, more correlated, and more synchronous. These developmental changes require normal visual input during development and are disrupted by NMDAR blockade. Our data show that visual activity and NMDAR activation are critical for the maturation of tectal network dynamics during visual system development.
Aizenman,
Visually driven regulation of intrinsic neuronal excitability improves stimulus detection in vivo.
2003, Pubmed,
Xenbase
Aizenman,
Visually driven regulation of intrinsic neuronal excitability improves stimulus detection in vivo.
2003,
Pubmed
,
Xenbase
Akerman,
Depolarizing GABAergic conductances regulate the balance of excitation to inhibition in the developing retinotectal circuit in vivo.
2006,
Pubmed
,
Xenbase
Badea,
Calcium imaging of epileptiform events with single-cell resolution.
2001,
Pubmed
Beggs,
Neuronal avalanches are diverse and precise activity patterns that are stable for many hours in cortical slice cultures.
2004,
Pubmed
Carr,
Processing of temporal information in the brain.
1993,
Pubmed
Cline,
Topographic maps: developing roles of synaptic plasticity.
1998,
Pubmed
Cossart,
Attractor dynamics of network UP states in the neocortex.
2003,
Pubmed
Crair,
Neuronal activity during development: permissive or instructive?
1999,
Pubmed
Debski,
Activity-dependent mapping in the retinotectal projection.
2002,
Pubmed
Deeg,
Development of multisensory convergence in the Xenopus optic tectum.
2009,
Pubmed
,
Xenbase
Demas,
Vision drives correlated activity without patterned spontaneous activity in developing Xenopus retina.
2012,
Pubmed
,
Xenbase
Dong,
Visual avoidance in Xenopus tadpoles is correlated with the maturation of visual responses in the optic tectum.
2009,
Pubmed
,
Xenbase
Doupe,
Cellular, circuit, and synaptic mechanisms in song learning.
2004,
Pubmed
Dunfield,
Metaplasticity governs natural experience-driven plasticity of nascent embryonic brain circuits.
2009,
Pubmed
,
Xenbase
Engert,
Moving visual stimuli rapidly induce direction sensitivity of developing tectal neurons.
2002,
Pubmed
,
Xenbase
Golshani,
Internally mediated developmental desynchronization of neocortical network activity.
2009,
Pubmed
Hiramoto,
Convergence of multisensory inputs in Xenopus tadpole tectum.
2009,
Pubmed
,
Xenbase
Ikegaya,
Synfire chains and cortical songs: temporal modules of cortical activity.
2004,
Pubmed
Komai,
Postsynaptic excitability is necessary for strengthening of cortical sensory responses during experience-dependent development.
2006,
Pubmed
Lisman,
Storage of 7 +/- 2 short-term memories in oscillatory subcycles.
1995,
Pubmed
Lázár,
The development of the optic tectum in Xenopus laevis: a Golgi study.
1974,
Pubmed
,
Xenbase
Maffei,
Network homeostasis: a matter of coordination.
2009,
Pubmed
Marder,
Variability, compensation and homeostasis in neuron and network function.
2006,
Pubmed
Massey,
Long-term depression: multiple forms and implications for brain function.
2007,
Pubmed
Mu,
Spike timing-dependent LTP/LTD mediates visual experience-dependent plasticity in a developing retinotectal system.
2006,
Pubmed
,
Xenbase
Nevin,
Hardwiring of fine synaptic layers in the zebrafish visual pathway.
2008,
Pubmed
Niell,
Functional imaging reveals rapid development of visual response properties in the zebrafish tectum.
2005,
Pubmed
Nikolenko,
Two-photon photostimulation and imaging of neural circuits.
2007,
Pubmed
Olshausen,
Sparse coding of sensory inputs.
2004,
Pubmed
Perkel,
Neuronal spike trains and stochastic point processes. II. Simultaneous spike trains.
1967,
Pubmed
Pratt,
Development and spike timing-dependent plasticity of recurrent excitation in the Xenopus optic tectum.
2008,
Pubmed
,
Xenbase
Pratt,
Homeostatic regulation of intrinsic excitability and synaptic transmission in a developing visual circuit.
2007,
Pubmed
,
Xenbase
Ramdya,
Reverse correlation of rapid calcium signals in the zebrafish optic tectum in vivo.
2006,
Pubmed
Reinagel,
Encoding of visual information by LGN bursts.
1999,
Pubmed
Ruthazer,
Learning to see: patterned visual activity and the development of visual function.
2010,
Pubmed
Ruthazer,
Insights into activity-dependent map formation from the retinotectal system: a middle-of-the-brain perspective.
2004,
Pubmed
Saito,
Local excitatory network and NMDA receptor activation generate a synchronous and bursting command from the superior colliculus.
2003,
Pubmed
Sasaki,
Fast and accurate detection of action potentials from somatic calcium fluctuations.
2008,
Pubmed
Schulz,
Plasticity and stability in neuronal output via changes in intrinsic excitability: it's what's inside that counts.
2006,
Pubmed
Somers,
An emergent model of orientation selectivity in cat visual cortical simple cells.
1995,
Pubmed
Song,
Competitive Hebbian learning through spike-timing-dependent synaptic plasticity.
2000,
Pubmed
Song,
Cortical development and remapping through spike timing-dependent plasticity.
2001,
Pubmed
Tao,
Activity-dependent matching of excitatory and inhibitory inputs during refinement of visual receptive fields.
2005,
Pubmed
,
Xenbase
Tian,
Visual stimulation is required for refinement of ON and OFF pathways in postnatal retina.
2003,
Pubmed
Tsui,
A developmental sensitive period for spike timing-dependent plasticity in the retinotectal projection.
2010,
Pubmed
,
Xenbase
Vislay-Meltzer,
Spatiotemporal specificity of neuronal activity directs the modification of receptive fields in the developing retinotectal system.
2006,
Pubmed
,
Xenbase
Yaksi,
Reconstruction of firing rate changes across neuronal populations by temporally deconvolved Ca2+ imaging.
2006,
Pubmed
Zhang,
Visual input induces long-term potentiation of developing retinotectal synapses.
2000,
Pubmed
,
Xenbase
Zhang,
A critical window for cooperation and competition among developing retinotectal synapses.
1998,
Pubmed
,
Xenbase
