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XB-ART-24615
Arch Biochem Biophys 1991 Aug 15;2891:71-5. doi: 10.1016/0003-9861(91)90443-m.
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Expression of the mouse macrophage cystine transporter in Xenopus laevis oocytes.

Ishii T , Nakayama K , Sato H , Miura K , Yamada M , Yamada K , Sugita Y , Bannai S .


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System xc- mediates transport of cystine and glutamate across the mammalian plasma membrane in a Na(+)-independent manner. This transport activity can be induced in mouse peritoneal macrophages during culture by diethylmaleate, a sulfhydryl-reactive agent. We injected mRNA from such macrophages into Xenopus oocytes and demonstrated the expression of System xc-, i.e., a Na(+)-independent, glutamate-inhibitable cysteine transport system. The expressed cystine transport activity depended on the assay temperature, in that cystine uptake measured at 37 degrees C was severalfold higher than that measured at 20 degrees C. Injection of size-fractionated mRNA indicated that the System xc- transporter of the mouse macrophage is encoded by mRNA of 1.5 to 2.9 kb.

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