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Am J Physiol Renal Physiol
2010 Oct 01;2994:F890-7. doi: 10.1152/ajprenal.00323.2010.
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Effects of dietary K on cell-surface expression of renal ion channels and transporters.
Frindt G
,
Palmer LG
.
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Changes in apical surface expression of ion channels and transporters in the superficial rat renal cortex were assessed using biotinylation and immunoblotting during alterations in dietary K intake. A high-K diet increased, and a low-K diet decreased, both the overall and surface abundance of the β- and γ-subunits of the epithelial Na channel (ENaC). In the case of γ-ENaC, the effect was specific for the 65-kDa cleaved form of the protein. The overall amount of α-ENAC was also increased with increasing K intake. The total expression of the secretory K(+) channels (ROMK) increased with a high-K diet and decreased with a low-K diet. The surface expression of ROMK increased with high K intake but was not significantly altered by a low-K diet. In contrast, the amounts of total and surface protein representing the thiazide-sensitive NaCl cotransporter (NCC) decreased with increasing K intake. We conclude that modulation of K(+) secretion in response to changes in dietary K intake involves changes in apical K(+) permeability through regulation of K(+) channels and in driving force subsequent to alterations in both Na delivery to the distalnephron and Na(+) uptake across the apical membrane of the K(+) secretory cells.
Chen,
Modest dietary K+ restriction provokes insulin resistance of cellular K+ uptake and phosphorylation of renal outer medulla K+ channel without fall in plasma K+ concentration.
2006, Pubmed
Chen,
Modest dietary K+ restriction provokes insulin resistance of cellular K+ uptake and phosphorylation of renal outer medulla K+ channel without fall in plasma K+ concentration.
2006,
Pubmed
Chu,
Dietary potassium restriction stimulates endocytosis of ROMK channel in rat cortical collecting duct.
2003,
Pubmed
,
Xenbase
Ecelbarger,
Regulation of potassium channel Kir 1.1 (ROMK) abundance in the thick ascending limb of Henle's loop.
2001,
Pubmed
Ecelbarger,
Localization and regulation of the rat renal Na(+)-K(+)-2Cl- cotransporter, BSC-1.
1996,
Pubmed
Ergonul,
Regulation of maturation and processing of ENaC subunits in the rat kidney.
2006,
Pubmed
Fallen,
The Kir channel immunoglobulin domain is essential for Kir1.1 (ROMK) thermodynamic stability, trafficking and gating.
2009,
Pubmed
Fang,
The ARH adaptor protein regulates endocytosis of the ROMK potassium secretory channel in mouse kidney.
2009,
Pubmed
Frindt,
Surface expression of epithelial Na channel protein in rat kidney.
2008,
Pubmed
,
Xenbase
Frindt,
Dietary K regulates ROMK channels in connecting tubule and cortical collecting duct of rat kidney.
2009,
Pubmed
,
Xenbase
Frindt,
Surface expression of sodium channels and transporters in rat kidney: effects of dietary sodium.
2009,
Pubmed
Frindt,
Na channels in the rat connecting tubule.
2004,
Pubmed
Frindt,
Dissociation of K channel density and ROMK mRNA in rat cortical collecting tubule during K adaptation.
1998,
Pubmed
Kahle,
WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion.
2003,
Pubmed
,
Xenbase
Lin,
Protein tyrosine kinase is expressed and regulates ROMK1 location in the cortical collecting duct.
2004,
Pubmed
Masilamani,
Aldosterone-mediated regulation of ENaC alpha, beta, and gamma subunit proteins in rat kidney.
1999,
Pubmed
Mennitt,
Potassium restriction downregulates ROMK expression in rat kidney.
2000,
Pubmed
Mennitt,
Localization of ROMK channels in the rat kidney.
1997,
Pubmed
,
Xenbase
Nesterov,
Trypsin can activate the epithelial sodium channel (ENaC) in microdissected mouse distal nephron.
2008,
Pubmed
Palmer,
Regulation of apical K and Na channels and Na/K pumps in rat cortical collecting tubule by dietary K.
1994,
Pubmed
Pochynyuk,
Dietary Na+ inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y2-receptor tone.
2010,
Pubmed
Pácha,
Regulation of Na channels of the rat cortical collecting tubule by aldosterone.
1993,
Pubmed
Subramanya,
WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron.
2006,
Pubmed
Vallon,
Expression and phosphorylation of the Na+-Cl- cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1.
2009,
Pubmed
Wang,
Regulation of potassium (K) handling in the renal collecting duct.
2009,
Pubmed
Wang,
Regulation of small-conductance K+ channel in apical membrane of rat cortical collecting tubule.
1990,
Pubmed
Wang,
Renal potassium channels and their regulation.
1992,
Pubmed
Wei,
Effect of dietary K intake on apical small-conductance K channel in CCD: role of protein tyrosine kinase.
2001,
Pubmed
Yang,
WNK kinases regulate thiazide-sensitive Na-Cl cotransport.
2003,
Pubmed
,
Xenbase
Yoo,
A phosphorylation-dependent export structure in ROMK (Kir 1.1) channel overrides an endoplasmic reticulum localization signal.
2005,
Pubmed
,
Xenbase
