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Postsynaptic calcium/calmodulin-dependent protein kinase II is required to limit elaboration of presynaptic and postsynaptic neuronal arbors.
Zou DJ
,
Cline HT
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Neuronal dendritic and axonal arbors grow to a characteristic size and then stabilize their structures. Activity-dependent stop-growing signals may limit neuronal process elaboration. We tested whether endogenous calcium/calmodulin-dependent protein kinase II (CaMKII) activity in postsynaptic optic tectal cells is required to restrict the elaboration of neuronal processes in the Xenopus tadpole retinotectal projection. Optic tectal cells were infected with vaccinia viruses that express CaMKII-specific inhibitory peptides. In vivo time-lapse imaging revealed that expression of CaMKII inhibitors blocked the growth restriction that normally occurs during maturation of tectal cell dendritic arbors. Postsynaptic CaMKII inhibition also increased the growth of presynaptic retinotectal axon arbors. The results indicate that endogenous postsynaptic CaMKII activity is required to limit the growth of presynaptic and postsynaptic arbor structures in vivo.
Baird,
Arrest of afferent axon extension by target neurons in vitro is regulated by the NMDA receptor.
1996, Pubmed
Baird,
Arrest of afferent axon extension by target neurons in vitro is regulated by the NMDA receptor.
1996,
Pubmed
Benson,
Differential gene expression for glutamic acid decarboxylase and type II calcium-calmodulin-dependent protein kinase in basal ganglia, thalamus, and hypothalamus of the monkey.
1991,
Pubmed
Braun,
The multifunctional calcium/calmodulin-dependent protein kinase: from form to function.
1995,
Pubmed
Chen,
A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II.
1998,
Pubmed
Cline,
Activity-dependent plasticity in the visual systems of frogs and fish.
1991,
Pubmed
Colbran,
Regulatory interactions of the calmodulin-binding, inhibitory, and autophosphorylation domains of Ca2+/calmodulin-dependent protein kinase II.
1988,
Pubmed
Constantine-Paton,
Patterned activity, synaptic convergence, and the NMDA receptor in developing visual pathways.
1990,
Pubmed
Davis,
Genetic analysis of the mechanisms controlling target selection: target-derived Fasciclin II regulates the pattern of synapse formation.
1997,
Pubmed
Evan,
Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.
1985,
Pubmed
,
Xenbase
Fannon,
A model for central synaptic junctional complex formation based on the differential adhesive specificities of the cadherins.
1996,
Pubmed
Fitzsimonds,
Retrograde signaling in the development and modification of synapses.
1998,
Pubmed
Fukunaga,
Long-term potentiation is associated with an increased activity of Ca2+/calmodulin-dependent protein kinase II.
1993,
Pubmed
Hahm,
Disruption of retinogeniculate afferent segregation by antagonists to NMDA receptors.
1991,
Pubmed
Hall,
Synaptic structure and development: the neuromuscular junction.
1993,
Pubmed
Hata,
Selective pruning of more active afferents when cat visual cortex is pharmacologically inhibited.
1999,
Pubmed
Ishida,
A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II.
1995,
Pubmed
Kelly,
Active site-directed inhibition of Ca2+/calmodulin-dependent protein kinase type II by a bifunctional calmodulin-binding peptide.
1988,
Pubmed
Lisman,
The CaM kinase II hypothesis for the storage of synaptic memory.
1994,
Pubmed
Liu,
Localization of alpha type II calcium calmodulin-dependent protein kinase at glutamatergic but not gamma-aminobutyric acid (GABAergic) synapses in thalamus and cerebral cortex.
1996,
Pubmed
Mainen,
Influence of dendritic structure on firing pattern in model neocortical neurons.
1996,
Pubmed
Malinow,
Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP.
1989,
Pubmed
Miller,
Regulation of brain type II Ca2+/calmodulin-dependent protein kinase by autophosphorylation: a Ca2+-triggered molecular switch.
1986,
Pubmed
O'Rourke,
Dynamic changes in optic fiber terminal arbors lead to retinotopic map formation: an in vivo confocal microscopic study.
1990,
Pubmed
,
Xenbase
Ouyang,
Visualization of the distribution of autophosphorylated calcium/calmodulin-dependent protein kinase II after tetanic stimulation in the CA1 area of the hippocampus.
1997,
Pubmed
Payne,
Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains.
1988,
Pubmed
Reh,
Eye-specific segregation requires neural activity in three-eyed Rana pipiens.
1985,
Pubmed
Reilein,
Regulation of organelle movement in melanophores by protein kinase A (PKA), protein kinase C (PKC), and protein phosphatase 2A (PP2A).
1998,
Pubmed
,
Xenbase
Rentería,
Exogenous nitric oxide causes collapse of retinal ganglion cell axonal growth cones in vitro.
1996,
Pubmed
,
Xenbase
Scheetz,
Chronic NMDA receptor antagonism during retinotopic map formation depresses CaM kinase II differentiation in rat superior colliculus.
1996,
Pubmed
Schlaggar,
Postsynaptic control of plasticity in developing somatosensory cortex.
1993,
Pubmed
Schworer,
Ca2+/calmodulin-dependent protein kinase II. Identification of a regulatory autophosphorylation site adjacent to the inhibitory and calmodulin-binding domains.
1988,
Pubmed
Shatz,
Prenatal tetrodotoxin infusion blocks segregation of retinogeniculate afferents.
1988,
Pubmed
Simon,
N-methyl-D-aspartate receptor antagonists disrupt the formation of a mammalian neural map.
1992,
Pubmed
Smith,
Functional determinants in the autoinhibitory domain of calcium/calmodulin-dependent protein kinase II. Role of His282 and multiple basic residues.
1992,
Pubmed
Sretavan,
Modification of retinal ganglion cell axon morphology by prenatal infusion of tetrodotoxin.
1988,
Pubmed
Stryker,
Binocular impulse blockade prevents the formation of ocular dominance columns in cat visual cortex.
1986,
Pubmed
Sík,
The absence of a major Ca2+ signaling pathway in GABAergic neurons of the hippocampus.
1998,
Pubmed
Waldmann,
Multifunctional Ca2+/calmodulin-dependent protein kinase made Ca2+ independent for functional studies.
1990,
Pubmed
,
Xenbase
Wang,
Concomitant alterations of physiological and developmental plasticity in Drosophila CaM kinase II-inhibited synapses.
1994,
Pubmed
Wu,
Stabilization of dendritic arbor structure in vivo by CaMKII.
1998,
Pubmed
,
Xenbase
Wu,
Involvement of nitric oxide in the elimination of a transient retinotectal projection in development.
1994,
Pubmed
Wu,
Dendritic dynamics in vivo change during neuronal maturation.
1999,
Pubmed
,
Xenbase
Wu,
Infection of frog neurons with vaccinia virus permits in vivo expression of foreign proteins.
1995,
Pubmed
,
Xenbase
Wu,
Maturation of a central glutamatergic synapse.
1996,
Pubmed
,
Xenbase
Zou,
Expression of constitutively active CaMKII in target tissue modifies presynaptic axon arbor growth.
1996,
Pubmed
,
Xenbase
Zou,
Control of retinotectal axon arbor growth by postsynaptic CaMKII.
1996,
Pubmed
