Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-39658
Dev Biol 2009 Jul 01;3311:89-98. doi: 10.1016/j.ydbio.2009.04.033.
Show Gene links Show Anatomy links

Cell-cell interactions during remodeling of the intestine at metamorphosis in Xenopus laevis.

Schreiber AM , Mukhi S , Brown DD .


???displayArticle.abstract???
Amphibian metamorphosis is accompanied by extensive intestinal remodeling. This process, mediated by thyroid hormone (TH) and its nuclear receptors, affects every cell type. Gut remodeling in Xenopus laevis involves epithelial and mesenchymal proliferation, smooth muscle thickening, neuronal aggregation, formation of intestinal folds, and shortening of its length by 75%. Transgenic tadpoles expressing a dominant negative TH receptor (TRDN) controlled by epithelial-, fibroblast-, and muscle-specific gene promoters were studied. TRDN expression in the epithelium caused abnormal development of virtually all cell types, with froglet guts displaying reduced intestinal folds, thin muscle and mesenchyme, absence of neurons, and reduced cell proliferation. TRDN expression in fibroblasts caused abnormal epithelia and mesenchyme development, and expression in muscle produced fewer enteric neurons and a reduced inter-muscular space. Gut shortening was inhibited only when TRDN was expressed in fibroblasts. Gut remodeling results from both cell-autonomous and cell-cell interactions.

???displayArticle.pubmedLink??? 19409886
???displayArticle.pmcLink??? PMC2712884
???displayArticle.link??? Dev Biol
???displayArticle.grants??? [+]

Species referenced: Xenopus laevis
Genes referenced: acta2 actl6a fabp2 mmp11 thibz trdn tubb2b
???displayArticle.antibodies??? Acta2 Ab1 Cdh1 Ab1 Fabp2 Ab1 Tubb2b Ab1


???attribute.lit??? ???displayArticles.show???
References [+] :
Amaya, A method for generating transgenic frog embryos. 1999, Pubmed, Xenbase