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XB-ART-42343
Channels (Austin) 2010 Jan 01;42:75-7. doi: 10.4161/chan.4.2.10998.
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Helical motion of an S4 voltage sensor revealed by gating pore currents.

Catterall WA , Yarov-Yarovoy V .


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The mechanism by which the voltage sensors of voltage-gated ion channels move gating charge during the activation process is a subject of active debate. In this issue of Channels, Gamal El-Din et al. probe the movements of the S4 voltage sensor of Shaker K(+) channels through clever use of omega gating pore currents generated by paired gating-charge mutations. Their results provide strong support for a sliding helix or helical screw mechanism of gating charge movement.

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Species referenced: Xenopus
Genes referenced: tbx2

References :
Gamal El-Din, Double gaps along Shaker S4 demonstrate omega currents at three different closed states. 2010, Pubmed, Xenbase