XB-ART-6795
Semin Cell Dev Biol
2002 Jun 01;133:251-60. doi: 10.1016/s1084-9521(02)00052-6.
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Non-canonical Wnt signalling and regulation of gastrulation movements.
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Members of the Wnt family have been implicated in a variety of developmental processes including axis formation, patterning of the central nervous system and tissue morphogenesis. Recent studies have shown that a Wnt signalling pathway similar to that involved in the establishment of planar cell polarity in Drosophila regulates convergent extension movements during zebrafish and Xenopus gastrulation. This finding provides a good starting point to dissect the complex cell biology and genetic regulation of vertebrate gastrulation movements.
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Species referenced: Xenopus
Genes referenced: axin1 cdc42 daam1 gpc6 ppt1 rhoa tcf3 wnt11 wnt5a wnt8a