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Cell Rep
2015 Aug 04;125:892-900. doi: 10.1016/j.celrep.2015.06.070.
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How Does the Xenopus laevis Embryonic Cell Cycle Avoid Spatial Chaos?
Gelens L
,
Huang KC
,
Ferrell JE
.
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Theoretical studies have shown that a deterministic biochemical oscillator can become chaotic when operating over a sufficiently large volume and have suggested that the Xenopus laevis cell cycle oscillator operates close to such a chaotic regime. To experimentally test this hypothesis, we decreased the speed of the post-fertilization calcium wave, which had been predicted to generate chaos. However, cell divisions were found to develop normally, and eggs developed into normal tadpoles. Motivated by these experiments, we carried out modeling studies to understand the prerequisites for the predicted spatial chaos. We showed that this type of spatial chaos requires oscillatory reaction dynamics with short pulse duration and postulated that the mitotic exit in Xenopus laevis is likely slow enough to avoid chaos. In systems with shorter pulses, chaos may be an important hazard, as in cardiac arrhythmias, or a useful feature, as in the pigmentation of certain mollusk shells.
Babloyantz,
Mechanisms of target and spiral wave propagation in single cells.
1994, Pubmed
Babloyantz,
Mechanisms of target and spiral wave propagation in single cells.
1994,
Pubmed
Bonnet,
Characterization of centrosomal localization and dynamics of Cdc25C phosphatase in mitosis.
2008,
Pubmed
Bub,
Spiral wave generation in heterogeneous excitable media.
2002,
Pubmed
Busa,
An elevated free cytosolic Ca2+ wave follows fertilization in eggs of the frog, Xenopus laevis.
1985,
Pubmed
,
Xenbase
Chang,
Mitotic trigger waves and the spatial coordination of the Xenopus cell cycle.
2013,
Pubmed
,
Xenbase
Chialvo,
Non-linear dynamics of cardiac excitation and impulse propagation.
,
Pubmed
Duckett,
Modeling the dynamics of cardiac action potentials.
2000,
Pubmed
Fitzhugh,
Impulses and Physiological States in Theoretical Models of Nerve Membrane.
1961,
Pubmed
Fontanilla,
Characterization of the sperm-induced calcium wave in Xenopus eggs using confocal microscopy.
1998,
Pubmed
,
Xenbase
Gelens,
Spatial trigger waves: positive feedback gets you a long way.
2014,
Pubmed
,
Xenbase
Hoffmann,
Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis.
1993,
Pubmed
,
Xenbase
Jackman,
Active cyclin B1-Cdk1 first appears on centrosomes in prophase.
2003,
Pubmed
Kim,
Substrate competition as a source of ultrasensitivity in the inactivation of Wee1.
2007,
Pubmed
,
Xenbase
King,
How proteolysis drives the cell cycle.
1996,
Pubmed
McGowan,
Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15.
1993,
Pubmed
McIsaac,
Does the potential for chaos constrain the embryonic cell-cycle oscillator?
2011,
Pubmed
,
Xenbase
Minshull,
Translation of cyclin mRNA is necessary for extracts of activated xenopus eggs to enter mitosis.
1989,
Pubmed
,
Xenbase
Mueller,
Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15.
1995,
Pubmed
,
Xenbase
Mueller,
Cell cycle regulation of a Xenopus Wee1-like kinase.
1995,
Pubmed
,
Xenbase
Murray,
Cyclin synthesis drives the early embryonic cell cycle.
1989,
Pubmed
,
Xenbase
Novak,
Numerical analysis of a comprehensive model of M-phase control in Xenopus oocyte extracts and intact embryos.
1993,
Pubmed
,
Xenbase
Panfilov,
Self-organized pacemakers in a coupled reaction-diffusion-mechanics system.
2005,
Pubmed
Parker,
Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase.
1992,
Pubmed
Pomerening,
Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2.
2003,
Pubmed
,
Xenbase
Pomerening,
Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations.
2005,
Pubmed
,
Xenbase
Rabinovitch,
A Model for the Propagation of Action Potentials in Non-Uniformly Excitable Media.
1999,
Pubmed
Romond,
Alternating oscillations and chaos in a model of two coupled biochemical oscillators driving successive phases of the cell cycle.
1999,
Pubmed
Sha,
Hysteresis drives cell-cycle transitions in Xenopus laevis egg extracts.
2003,
Pubmed
,
Xenbase
Solomon,
Cyclin activation of p34cdc2.
1990,
Pubmed
,
Xenbase
Sridhar,
Anomalous drift of spiral waves in heterogeneous excitable media.
2010,
Pubmed
Starmer,
Vulnerability in an excitable medium: analytical and numerical studies of initiating unidirectional propagation.
1993,
Pubmed
Steinberg,
The role of heterogeneities and intercellular coupling in wave propagation in cardiac tissue.
2006,
Pubmed
Tang,
Two distinct mechanisms for negative regulation of the Wee1 protein kinase.
1993,
Pubmed
,
Xenbase
Trunnell,
Ultrasensitivity in the Regulation of Cdc25C by Cdk1.
2011,
Pubmed
,
Xenbase
Tsai,
Changes in oscillatory dynamics in the cell cycle of early Xenopus laevis embryos.
2014,
Pubmed
,
Xenbase
Vinod,
The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles.
2013,
Pubmed
,
Xenbase
Winfree,
Electrical instability in cardiac muscle: phase singularities and rotors.
1989,
Pubmed
Yang,
The Cdk1-APC/C cell cycle oscillator circuit functions as a time-delayed, ultrasensitive switch.
2013,
Pubmed
,
Xenbase
Zhou,
Study of propagation along nonuniform excitable fibers.
1994,
Pubmed
