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XB-ART-20573
Proc Natl Acad Sci U S A 1994 Nov 08;9123:10844-8.
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Cadherin-mediated cell interactions are necessary for the activation of MyoD in Xenopus mesoderm.

Holt CE , Lemaire P , Gurdon JB .


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Muscle progenitors in Xenopus interact in a community of 100 or more cells to activate their myogenic genes and the muscle differentiation pathway. We examine whether the cell adhesion molecule cadherin is involved in this process. Injections of dominant negative N-cadherin RNA into the region of 2- to 4-cell embryos that will give rise to muscle suppress MyoD expression in muscle progenitor cells. By contrast, Xbra expression is unaffected and levels of Xwnt-8 message rise with increasing doses of dominant negative cadherin RNA. MyoD inhibition in embryos injected with the dominant negative cadherin mRNA is rescued by coinjection of full-length cadherin RNA, showing that the inhibition of MyoD occurs through the cadherin pathway. These results show that cadherin-mediated cell interactions play a critical role in the signaling events required for muscle progenitor cells to differentiate, as judged by their stable activation of MyoD.

???displayArticle.pubmedLink??? 7971972
???displayArticle.pmcLink??? PMC45122
???displayArticle.link??? Proc Natl Acad Sci U S A
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Species referenced: Xenopus laevis
Genes referenced: cdh1 cdh2 myc myod1 ncam1 tbxt wnt8a
???displayArticle.antibodies??? Myod1 Ab1 Ncam1 Ab2 Somite Ab1


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References [+] :
Angres, Differential expression of two cadherins in Xenopus laevis. 1991, Pubmed, Xenbase