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J Am Soc Nephrol
2008 Sep 01;199:1732-40. doi: 10.1681/ASN.2008020180.
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Organic anion transporter 3 contributes to the regulation of blood pressure.
Vallon V
,
Eraly SA
,
Wikoff WR
,
Rieg T
,
Kaler G
,
Truong DM
,
Ahn SY
,
Mahapatra NR
,
Mahata SK
,
Gangoiti JA
,
Wu W
,
Barshop BA
,
Siuzdak G
,
Nigam SK
.
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Renal organic anion transporters (OAT) are known to mediate the excretion of many drugs, but their function in normal physiology is not well understood. In this study, mice lacking organic anion transporter 3 (Oat3) had a 10 to 15% lower BP than wild-type mice, raising the possibility that Oat3 transports an endogenous regulator of BP. The aldosterone response to a low-salt diet was blunted in Oat3-null mice, but baseline aldosterone concentration was higher in these mice, suggesting that aldosterone dysregulation does not fully explain the lower BP in the basal state; therefore, both targeted and global metabolomic analyses of plasma and urine were performed, and several potential endogenous substrates of Oat3 were found to accumulate in the plasma of Oat3-null mice. One of these substrates, thymidine, was transported by Oat3 expressed in vitro. In vivo, thymidine, as well as two of the most potent Oat3 inhibitors that were characterized, reduced BP by 10 to 15%; therefore, Oat3 seems to regulate BP, and Oat3 inhibitors might be therapeutically useful antihypertensive agents. Moreover, polymorphisms in human OAT3 might contribute to the genetic variation in susceptibility to hypertension.
Asif,
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Asif,
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2005,
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,
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Bahn,
Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites.
2005,
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Bakhiya,
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2003,
Pubmed
,
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Brady,
A novel putative transporter maps to the osteosclerosis (oc) mutation and is not expressed in the oc mutant mouse.
1999,
Pubmed
Burckhardt,
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2003,
Pubmed
Burckhardt,
Molecular physiology of renal p-aminohippurate secretion.
2001,
Pubmed
Cha,
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2001,
Pubmed
,
Xenbase
Dantzler,
The molecular and cellular physiology of basolateral organic anion transport in mammalian renal tubules.
2003,
Pubmed
Enomoto,
Molecular identification of a renal urate anion exchanger that regulates blood urate levels.
2002,
Pubmed
,
Xenbase
Eraly,
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2003,
Pubmed
Eraly,
The molecular pharmacology of organic anion transporters: from DNA to FDA?
2004,
Pubmed
Eraly,
Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice.
2006,
Pubmed
,
Xenbase
Eraly,
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2008,
Pubmed
Harris,
Cyclooxygenase-2 and the renal renin-angiotensin system.
2004,
Pubmed
Hasegawa,
Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions.
2002,
Pubmed
Hosoyamada,
Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney.
1999,
Pubmed
,
Xenbase
Ishimura,
Light and electron microscopic immunohistochemistry of the localization of adrenal steroidogenic enzymes.
1997,
Pubmed
Kaler,
Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members.
2007,
Pubmed
Kim,
Adenosine as a mediator of macula densa-dependent inhibition of renin secretion.
2006,
Pubmed
Koepsell,
The SLC22 drug transporter family.
2004,
Pubmed
Kojima,
Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3, in rat kidney.
2002,
Pubmed
Lee,
Blood thymidine level and iododeoxyuridine incorporation and reutilization in DNA in mice given long-acting thymidine pellets.
1976,
Pubmed
Ljubojevic,
Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition.
2004,
Pubmed
Lopez-Nieto,
Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney.
1997,
Pubmed
,
Xenbase
Meiner,
Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals.
1996,
Pubmed
Mori,
Kidney-specific expression of a novel mouse organic cation transporter-like protein.
1997,
Pubmed
Motohashi,
Gene expression levels and immunolocalization of organic ion transporters in the human kidney.
2002,
Pubmed
Nigam,
Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues.
2007,
Pubmed
,
Xenbase
Nilwarangkoon,
Role of mouse organic anion transporter 3 (mOat3) as a basolateral prostaglandin E2 transport pathway.
2007,
Pubmed
,
Xenbase
Rieg,
Adenosine A1 receptors determine effects of caffeine on total fluid intake but not caffeine appetite.
2007,
Pubmed
Rieg,
Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption.
2007,
Pubmed
Robertson,
Human renal organic anion transporters: characteristics and contributions to drug and drug metabolite excretion.
2006,
Pubmed
Schneider,
Progesterone receptors mediate male aggression toward infants.
2003,
Pubmed
Smith,
XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification.
2006,
Pubmed
Sweet,
The organic anion transporter family: from physiology to ontogeny and the clinic.
2001,
Pubmed
Sweet,
Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice.
2002,
Pubmed
,
Xenbase
Sweet,
Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient.
2003,
Pubmed
,
Xenbase
Sweet,
Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney.
1997,
Pubmed
,
Xenbase
Tojo,
Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney.
1999,
Pubmed
Truong,
Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination.
2008,
Pubmed
,
Xenbase
Vallon,
KCNQ1-dependent transport in renal and gastrointestinal epithelia.
2005,
Pubmed
Vallon,
SGK1-dependent cardiac CTGF formation and fibrosis following DOCA treatment.
2006,
Pubmed
Vallon,
Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics.
2008,
Pubmed
,
Xenbase
Vallon,
SGK1 as a determinant of kidney function and salt intake in response to mineralocorticoid excess.
2005,
Pubmed
VanWert,
Impaired clearance of methotrexate in organic anion transporter 3 (Slc22a8) knockout mice: a gender specific impact of reduced folates.
2008,
Pubmed
Vanwert,
Organic anion transporter 3 (Oat3/Slc22a8) knockout mice exhibit altered clearance and distribution of penicillin G.
2007,
Pubmed
Vincent,
Steroids during development of genetic hypertension in rats of Lyon strain.
1989,
Pubmed
Vinson,
Glomerulosa function and aldosterone synthesis in the rat.
2004,
Pubmed
Wright,
Molecular and cellular physiology of renal organic cation and anion transport.
2004,
Pubmed