XB-ART-51127
Cold Spring Harb Perspect Biol
2016 Apr 01;84:a019083. doi: 10.1101/cshperspect.a019083.
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Cell-Size Control.
Amodeo AA
,
Skotheim JM
.
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Cells of a given type maintain a characteristic cell size to function efficiently in their ecological or organismal context. They achieve this through the regulation of growth rates or by actively sensing size and coupling this signal to cell division. We focus this review on potential size-sensing mechanisms, including geometric, external cue, and titration mechanisms. Mechanisms that titrate proteins against DNA are of particular interest because they are consistent with the robust correlation of DNA content and cell size. We review the literature, which suggests that titration mechanisms may underlie cell-size sensing in Xenopus embryos, budding yeast, and Escherichia coli, whereas alternative mechanisms may function in fission yeast.
???displayArticle.pubmedLink??? 26254313
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???displayArticle.grants??? [+]
R21 HD073772 NICHD NIH HHS , R21HD073772 NICHD NIH HHS , T32 GM007276 NIGMS NIH HHS , P50 GM107615 NIGMS NIH HHS , T32GM007276 NIGMS NIH HHS
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