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The HCN domain is required for HCN channel cell-surface expression and couples voltage- and cAMP-dependent gating mechanisms. , Wang ZJ., J Biol Chem. June 12, 2020; 295 (24): 8164-8173.
The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function. , Silbernagel N., FASEB J. November 1, 2018; 32 (11): 6159-6173.
Minimal molecular determinants of isoform-specific differences in efficacy in the HCN channel family. , Alvarez-Baron CP., J Gen Physiol. August 6, 2018; 150 (8): 1203-1213.
Ligand binding and activation properties of the purified bacterial cyclic nucleotide-gated channel SthK. , Schmidpeter PAM., J Gen Physiol. June 4, 2018; 150 (6): 821-834.
Gabapentin Modulates HCN4 Channel Voltage-Dependence. , Tae HS., Front Pharmacol. May 26, 2017; 8 554.
An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities. , Wemhöner K., Front Mol Neurosci. November 3, 2015; 8 63.
A di-arginine ER retention signal regulates trafficking of HCN1 channels from the early secretory pathway to the plasma membrane. , Pan Y., Cell Mol Life Sci. February 1, 2015; 72 (4): 833-43.
Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels. , Wilkars W., FASEB J. May 1, 2014; 28 (5): 2177-90.
Binding of the auxiliary subunit TRIP8b to HCN channels shifts the mode of action of cAMP. , Hu L., J Gen Physiol. December 1, 2013; 142 (6): 599-612.
Protein kinase C activation inhibits rat and human hyperpolarization activated cyclic nucleotide gated channel (HCN)1--mediated current in mammalian cells. , Reetz O., Cell Physiol Biochem. January 1, 2013; 31 (4-5): 532-41.
Local anesthetic inhibits hyperpolarization-activated cationic currents. , Meng QT., Mol Pharmacol. May 1, 2011; 79 (5): 866-73.
Associated changes in HCN2 and HCN4 transcripts and I(f) pacemaker current in myocytes. , Zhang Q ., Biochim Biophys Acta. May 1, 2009; 1788 (5): 1138-47.
Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels. , Elinder F., J Physiol. September 1, 2006; 575 (Pt 2): 417-31.
Suppression of ih contributes to propofol-induced inhibition of mouse cortical pyramidal neurons. , Chen X., J Neurophysiol. December 1, 2005; 94 (6): 3872-83.
Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol. , Cacheaux LP., J Pharmacol Exp Ther. November 1, 2005; 315 (2): 517-25.
Hysteresis in the voltage dependence of HCN channels: conversion between two modes affects pacemaker properties. , Männikkö R., J Gen Physiol. March 1, 2005; 125 (3): 305-26.
Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction. , Santoro B., J Neurosci. November 24, 2004; 24 (47): 10750-62.
S4 movement in a mammalian HCN channel. , Vemana S., J Gen Physiol. January 1, 2004; 123 (1): 21-32.
Tyrosine kinase inhibition differentially regulates heterologously expressed HCN channels. , Yu HG., Pflugers Arch. January 1, 2004; 447 (4): 392-400.
KCNE2 modulates current amplitudes and activation kinetics of HCN4: influence of KCNE family members on HCN4 currents. , Decher N., Pflugers Arch. September 1, 2003; 446 (6): 633-40.
Regulation of hyperpolarization-activated HCN channel gating and cAMP modulation due to interactions of COOH terminus and core transmembrane regions. , Wang J ., J Gen Physiol. September 1, 2001; 118 (3): 237-50.
Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide. , Chen S., J Gen Physiol. May 1, 2001; 117 (5): 491-504.
Functional heteromerization of HCN1 and HCN2 pacemaker channels. , Ulens C., J Biol Chem. March 2, 2001; 276 (9): 6069-72.