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Functional and clinical characterization of a novel homozygous KCNH2 missense variant in the pore region of Kv11.1 leading to a viable but severe long-QT syndrome. , Delinière A., Gene. March 1, 2024; 897 148076.
External Cd2+ and protons activate the hyperpolarization-gated K+ channel KAT1 at the voltage sensor. , Zhou Y., J Gen Physiol. January 4, 2021; 153 (1):
Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds. , Hull CM., Am J Physiol Regul Integr Comp Physiol. December 1, 2019; 317 (6): R921-R931.
Temperature Dependence of the Biophysical Mechanisms Underlying the Inhibition and Enhancement Effect of Amiodarone on hERG Channels. , Lo YC., Mol Pharmacol. September 1, 2019; 96 (3): 330-344.
Nocturnal Atrial Fibrillation Caused by Mutation in KCND2, Encoding Pore-Forming (α) Subunit of the Cardiac Kv4.2 Potassium Channel. , Drabkin M., Circ Genom Precis Med. November 1, 2018; 11 (11): e002293.
Two mutations at different positions in the CNBH domain of the hERG channel accelerate deactivation and impair the interaction with the EAG domain. , Kume S., J Physiol. October 1, 2018; 596 (19): 4629-4650.
Functional characterization of Kv11.1 (hERG) potassium channels split in the voltage-sensing domain. , de la Peña P., Pflugers Arch. July 1, 2018; 470 (7): 1069-1085.
Dynamic rearrangement of the intrinsic ligand regulates KCNH potassium channels. , Dai G., J Gen Physiol. April 2, 2018; 150 (4): 625-635.
The Fast Component of hERG Gating Charge: An Interaction between D411 in the S1 and S4 Residues. , Dou Y., Biophys J. November 7, 2017; 113 (9): 1979-1991.
Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4. , Abbott GW., Sci Rep. December 6, 2016; 6 38412.
Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains. , Lörinczi É., Nat Commun. March 30, 2015; 6 6672.
Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels. , Cristofori-Armstrong B., Sci Rep. January 12, 2015; 5 14763.
Ginseng gintonin activates the human cardiac delayed rectifier K+ channel: involvement of Ca2+/calmodulin binding sites. , Choi SH., Mol Cells. September 1, 2014; 37 (9): 656-63.
The variant hERG/R148W associated with LQTS is a mutation that reduces current density on co-expression with the WT. , Mechakra A., Gene. February 25, 2014; 536 (2): 348-56.
External pH modulates EAG superfamily K+ channels through EAG-specific acidic residues in the voltage sensor. , Kazmierczak M., J Gen Physiol. June 1, 2013; 141 (6): 721-35.
Impaired ion channel function related to a common KCNQ1 mutation - implications for risk stratification in long QT syndrome 1. , Aidery P., Gene. December 10, 2012; 511 (1): 26-33.
Kcnh1 voltage-gated potassium channels are essential for early zebrafish development. , Stengel R., J Biol Chem. October 12, 2012; 287 (42): 35565-35575.
Tuning of EAG K(+) channel inactivation: molecular determinants of amplification by mutations and a small molecule. , Garg V., J Gen Physiol. September 1, 2012; 140 (3): 307-24.
Inhibition of cardiac Kir2.1-2.3 channels by beta3 adrenoreceptor antagonist SR 59230A. , Kulzer M., Biochem Biophys Res Commun. July 27, 2012; 424 (2): 315-20.
18β-Glycyrrhetinic acid preferentially blocks late Na current generated by ΔKPQ Nav1.5 channels. , Du YM., Acta Pharmacol Sin. June 1, 2012; 33 (6): 752-60.
Stimulation of HERG channel activity by β-catenin. , Munoz C., PLoS One. January 1, 2012; 7 (8): e43353.
Differential effects of ginsenoside metabolites on HERG k channel currents. , Choi SH., J Ginseng Res. June 1, 2011; 35 (2): 191-9.
hERGAPDbase: a database documenting hERG channel inhibitory potentials and APD-prolongation activities of chemical compounds. , Hishigaki H., Database (Oxford). May 17, 2011; 2011 bar017.
Modification of hERG1 channel gating by Cd2+. , Abbruzzese J., J Gen Physiol. August 1, 2010; 136 (2): 203-24.
Fluorescence-tracking of activation gating in human ERG channels reveals rapid S4 movement and slow pore opening. , Es-Salah-Lamoureux Z., PLoS One. May 3, 2010; 5 (5): e10876.
Inhibition of the human ether-a- go-go-related gene ( HERG) K+ channels by Lindera erythrocarpa. , Hong HK., J Korean Med Sci. December 1, 2009; 24 (6): 1089-98.
Characterization of novel KCNH2 mutations in type 2 long QT syndrome manifesting as seizures. , Keller DI., Can J Cardiol. August 1, 2009; 25 (8): 455-62.
[The persistent expression of HERG channel in Xenopus oocyte and alteration of current]. , Wang XP ., Zhongguo Ying Yong Sheng Li Xue Za Zhi. August 1, 2008; 24 (3): 329-33.
Inhibition of cardiac hERG potassium channels by tetracyclic antidepressant mianserin. , Scherer D., Naunyn Schmiedebergs Arch Pharmacol. July 1, 2008; 378 (1): 73-83.
In vitro modulation of HERG channels by organochlorine solvent trichlormethane as potential explanation for proarrhythmic effects of chloroform. , Scholz EP., Toxicol Lett. August 20, 2006; 165 (2): 156-66.
[Electrophysiological characterization of long QT syndrome associated mutations V630A and N633S]. , She HR., Zhonghua Xin Xue Guan Bing Za Zhi. June 1, 2006; 34 (6): 523-7.
Atypical tetracyclic antidepressant maprotiline is an antagonist at cardiac hERG potassium channels. , Kiesecker C., Naunyn Schmiedebergs Arch Pharmacol. June 1, 2006; 373 (3): 212-20.
Gating charges in the activation and inactivation processes of the HERG channel. , Zhang M., J Gen Physiol. December 1, 2004; 124 (6): 703-18.
Identification and characterisation of a novel KCNQ1 mutation in a family with Romano-Ward syndrome. , Zehelein J., Biochim Biophys Acta. November 5, 2004; 1690 (3): 185-92.
Activation properties of Kv4.3 channels: time, voltage and [K+]o dependence. , Wang S., J Physiol. June 15, 2004; 557 (Pt 3): 705-17.
Inactivation gating determines drug potency: a common mechanism for drug blockade of HERG channels. , Yang BF., Acta Pharmacol Sin. May 1, 2004; 25 (5): 554-60.
Gating currents associated with intramembrane charge displacement in HERG potassium channels. , Piper DR., Proc Natl Acad Sci U S A. September 2, 2003; 100 (18): 10534-9.
[Electropharmacological assessment of the risk of drug-induced long-QT syndrome using native cardiac cells and cultured cells expressing HERG channels]. , Nakaya H., Nihon Yakurigaku Zasshi. June 1, 2003; 121 (6): 384-92.
RNA interference reveals that endogenous Xenopus MinK-related peptides govern mammalian K+ channel function in oocyte expression studies. , Anantharam A., J Biol Chem. April 4, 2003; 278 (14): 11739-45.
Structural and functional role of the extracellular s5-p linker in the HERG potassium channel. , Liu J ., J Gen Physiol. November 1, 2002; 120 (5): 723-37.
Kinetic modulation of HERG potassium channels by the volatile anesthetic halothane. , Li J., Anesthesiology. October 1, 2002; 97 (4): 921-30.
Characterization of a novel missense mutation E637K in the pore-S6 loop of HERG in a patient with long QT syndrome. , Hayashi K., Cardiovasc Res. April 1, 2002; 54 (1): 67-76.
Long-QT syndrome-associated missense mutations in the pore helix of the HERG potassium channel. , Huang FD., Circulation. August 28, 2001; 104 (9): 1071-5.
MinK subdomains that mediate modulation of and association with KvLQT1. , Tapper AR., J Gen Physiol. September 1, 2000; 116 (3): 379-90.
Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate. , Mitcheson JS., J Gen Physiol. March 1, 2000; 115 (3): 229-40.
Ultrafast inactivation causes inward rectification in a voltage-gated K(+) channel from Caenorhabditis elegans. , Fleischhauer R., J Neurosci. January 15, 2000; 20 (2): 511-20.
Analysis of the human KCNH2( HERG) gene: identification and characterization of a novel mutation Y667X associated with long QT syndrome and a non-pathological 9 bp insertion. , Paulussen A., Hum Mutat. January 1, 2000; 15 (5): 483.
Novel mechanism associated with an inherited cardiac arrhythmia: defective protein trafficking by the mutant HERG (G601S) potassium channel. , Furutani M., Circulation. May 4, 1999; 99 (17): 2290-4.
Long QT syndrome-associated mutations in the Per- Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation. , Chen J ., J Biol Chem. April 9, 1999; 274 (15): 10113-8.
Regulation of deactivation by an amino terminal domain in human ether-à- go-go-related gene potassium channels. , Wang J ., J Gen Physiol. November 1, 1998; 112 (5): 637-47.