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Integrative analysis confirms TPX2 as a novel biomarker for clinical implication, tumor microenvironment, and immunotherapy response across human solid tumors. , Zhu M., Aging (Albany NY). February 2, 2024; 16 (3): 2563-2590.
Augmin is a Ran-regulated spindle assembly factor. , Kraus J., J Biol Chem. June 1, 2023; 299 (6): 104736.
Comprehensive Analysis of the Oncogenic Role of Targeting Protein for Xklp2 (TPX2) in Human Malignancies. , Shao T., Dis Markers. January 1, 2022; 2022 7571066.
High nuclear TPX2 expression correlates with TP53 mutation and poor clinical behavior in a large breast cancer cohort, but is not an independent predictor of chromosomal instability. , Matson DR., BMC Cancer. February 23, 2021; 21 (1): 186.
Nocodazole-Induced Expression and Phosphorylation of Anillin and Other Mitotic Proteins Are Decreased in DNA-Dependent Protein Kinase Catalytic Subunit-Deficient Cells and Rescued by Inhibition of the Anaphase-Promoting Complex/Cyclosome with proTAME but Not Apcin. , Douglas P., Mol Cell Biol. June 15, 2020; 40 (13):
Cell Biology: Tubulin Contributes to Spindle Size Scaling. , Levy DL ., Curr Biol. June 8, 2020; 30 (11): R637-R639.
Therapeutic Rationale to Target Highly Expressed Aurora kinase A Conferring Poor Prognosis in Cholangiocarcinoma. , Ding X., J Cancer. February 3, 2020; 11 (8): 2241-2251.
Biochemical reconstitution of branching microtubule nucleation. , Alfaro-Aco R., Elife. January 14, 2020; 9
Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation. , King MR ., Nat Commun. January 14, 2020; 11 (1): 270.
Integrated Bioinformatic Analysis Identifies Networks and Promising Biomarkers for Hepatitis B Virus-Related Hepatocellular Carcinoma. , Ji Y., Int J Genomics. January 1, 2020; 2020 2061024.
Kif2a Scales Meiotic Spindle Size in Hymenochirus boettgeri. , Miller KE., Curr Biol. November 4, 2019; 29 (21): 3720-3727.e5.
Spatiotemporal organization of branched microtubule networks. , Thawani A., Elife. May 8, 2019; 8
Importin α Partitioning to the Plasma Membrane Regulates Intracellular Scaling. , Brownlee C., Cell. February 7, 2019; 176 (4): 805-815.e8.
Targeting TPX2 suppresses proliferation and promotes apoptosis via repression of the PI3k/AKT/P21 signaling pathway and activation of p53 pathway in breast cancer. , Chen M., Biochem Biophys Res Commun. December 9, 2018; 507 (1-4): 74-82.
Dissecting Protein Complexes in Branching Microtubule Nucleation Using Meiotic Xenopus Egg Extracts. , Song JG., Cold Spring Harb Protoc. September 4, 2018; 2018 (9):
Overexpression of TPX2 is associated with progression and prognosis of prostate cancer. , Zou J., Oncol Lett. September 1, 2018; 16 (3): 2823-2832.
Mechanism of how augmin directly targets the γ-tubulin ring complex to microtubules. , Song JG., J Cell Biol. July 2, 2018; 217 (7): 2417-2428.
Subcellular scaling: does size matter for cell division? , Heald R ., Curr Opin Cell Biol. June 1, 2018; 52 88-95.
Spindle assembly in egg extracts of the Marsabit clawed frog, Xenopus borealis. , Kitaoka M., Cytoskeleton (Hoboken). June 1, 2018; 75 (6): 244-257.
Clinical value of Xenopus kinesin-like protein 2 as a prognostic marker in patients with digestive system cancers: a systematic review and meta-analysis. , Wang G., Onco Targets Ther. March 5, 2018; 11 1229-1243.
Aurora A activation in mitosis promoted by BuGZ. , Huang Y., J Cell Biol. January 2, 2018; 217 (1): 107-116.
TPX2 promotes cell proliferation and migration via PLK1 in OC. , Ma S., Cancer Biomark. January 1, 2018; 22 (3): 443-451.
Regulation of mitotic spindle assembly factor NuMA by Importin-β. , Chang CC ., J Cell Biol. November 6, 2017; 216 (11): 3453-3462.
Structural analysis of the role of TPX2 in branching microtubule nucleation. , Alfaro-Aco R., J Cell Biol. April 3, 2017; 216 (4): 983-997.
TPX2 promotes glioma cell proliferation and invasion via activation of the AKT signaling pathway. , Gu JJ., Oncol Lett. December 1, 2016; 12 (6): 5015-5022.
The C-terminal domain of TPX2 is made of alpha-helical tandem repeats. , Sanchez-Pulido L., BMC Struct Biol. October 26, 2016; 16 (1): 17.
The sequential activation of the mitotic microtubule assembly pathways favors bipolar spindle formation. , Cavazza T., Mol Biol Cell. October 1, 2016; 27 (19): 2935-45.
Mitotic noncoding RNA processing promotes kinetochore and spindle assembly in Xenopus. , Grenfell AW., J Cell Biol. July 18, 2016; 214 (2): 133-41.
A versatile multivariate image analysis pipeline reveals features of Xenopus extract spindles. , Grenfell AW., J Cell Biol. April 11, 2016; 213 (1): 127-36.
An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis. , Meunier S., Nat Commun. August 5, 2015; 6 7889.
TPX2 phosphorylation maintains metaphase spindle length by regulating microtubule flux. , Fu J., J Cell Biol. August 3, 2015; 210 (3): 373-83.
TPX2 as a novel prognostic biomarker for hepatocellular carcinoma. , Liu Q., Hepatol Res. August 1, 2015; 45 (8): 906-18.
GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules. , Wei JH., Cell. July 16, 2015; 162 (2): 287-99.
Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly. , Burgess SG., PLoS Genet. July 1, 2015; 11 (7): e1005345.
The Ran-GTP gradient spatially regulates XCTK2 in the spindle. , Weaver LN., Curr Biol. June 1, 2015; 25 (11): 1509-14.
Phosphorylation of targeting protein for Xenopus kinesin-like protein 2 ( TPX2) at threonine 72 in spindle assembly. , Shim SY ., J Biol Chem. April 3, 2015; 290 (14): 9122-34.
Microtubule nucleation in mitosis by a RanGTP-dependent protein complex. , Scrofani J., Curr Biol. January 19, 2015; 25 (2): 131-140.
Purification of nuclear localization signal-containing proteins and its application to investigation of the mechanisms of the cell division cycle. , Christodoulou A., Small GTPases. January 1, 2015; 6 (1): 20-7.
TPX2 is a prognostic marker and contributes to growth and metastasis of human hepatocellular carcinoma. , Huang Y., Int J Mol Sci. October 9, 2014; 15 (10): 18148-61.
TPX2 levels modulate meiotic spindle size and architecture in Xenopus egg extracts. , Helmke KJ., J Cell Biol. August 4, 2014; 206 (3): 385-93.
TPX2 knockdown suppressed hepatocellular carcinoma cell invasion via inactivating AKT signaling and inhibiting MMP2 and MMP9 expression. , Liu Q., Chin J Cancer Res. August 1, 2014; 26 (4): 410-7.
TPX2 overexpression in medullary thyroid carcinoma mediates TT cell proliferation. , Yang X., Pathol Oncol Res. July 1, 2014; 20 (3): 641-8.
Transportin acts to regulate mitotic assembly events by target binding rather than Ran sequestration. , Bernis C., Mol Biol Cell. April 1, 2014; 25 (7): 992-1009.
The Prp19 complex directly functions in mitotic spindle assembly. , Hofmann JC., PLoS One. September 3, 2013; 8 (9): e74851.
The centriolar satellite protein SSX2IP promotes centrosome maturation. , Bärenz F., J Cell Biol. July 8, 2013; 202 (1): 81-95.
Mitotic spindle scaling during Xenopus development by kif2a and importin α. , Wilbur JD., Elife. February 19, 2013; 2 e00290.
Branching microtubule nucleation in Xenopus egg extracts mediated by augmin and TPX2. , Petry S ., Cell. February 14, 2013; 152 (4): 768-77.
Targeting protein for xenopus kinesin-like protein 2 ( TPX2) regulates γ-histone 2AX (γ- H2AX) levels upon ionizing radiation. , Neumayer G., J Biol Chem. December 7, 2012; 287 (50): 42206-22.
Activation of Aurora-A kinase by protein partner binding and phosphorylation are independent and synergistic. , Dodson CA., J Biol Chem. January 6, 2012; 287 (2): 1150-7.
Mitotic spindle assembly around RCC1-coated beads in Xenopus egg extracts. , Halpin D., PLoS Biol. December 1, 2011; 9 (12): e1001225.