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Licorice metabolite 18β-glycyrrhetinic acid activates G protein-gated inwardly rectifying K+ channels. , Chen IS., Br J Pharmacol. February 1, 2024; 181 (3): 447-463.
Non-sedating antihistamines block G-protein-gated inwardly rectifying K+ channels. , Chen IS., Br J Pharmacol. September 1, 2019; 176 (17): 3161-3179.
Structural determinants at the M2 muscarinic receptor modulate the RGS4- GIRK response to pilocarpine by impairment of the receptor voltage sensitivity. , Chen IS., Sci Rep. July 21, 2017; 7 (1): 6110.
Cholesterol up-regulates neuronal G protein-gated inwardly rectifying potassium (GIRK) channel activity in the hippocampus. , Bukiya AN., J Biol Chem. April 14, 2017; 292 (15): 6135-6147.
A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ. , Yakubovich D., PLoS Comput Biol. November 6, 2015; 11 (11): e1004598.
Differential effects of genetically-encoded Gβγ scavengers on receptor-activated and basal Kir3.1/ Kir3.4 channel current in rat atrial myocytes. , Kienitz MC., Cell Signal. June 1, 2014; 26 (6): 1182-1192.
RGS4 regulates partial agonism of the M2 muscarinic receptor-activated K+ currents. , Chen IS., J Physiol. March 15, 2014; 592 (6): 1237-48.
The polarization of the G-protein activated potassium channel GIRK5 to the vegetal pole of Xenopus laevis oocytes is driven by a di-leucine motif. , Díaz-Bello B., PLoS One. May 15, 2013; 8 (5): e64096.
Discovery, characterization, and structure-activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2.3, Kir3.x, and Kir7.1. , Raphemot R., Front Pharmacol. November 30, 2011; 2 75.
Crystal structure of the mammalian GIRK2 K+ channel and gating regulation by G proteins, PIP2, and sodium. , Whorton MR., Cell. September 30, 2011; 147 (1): 199-208.
Agonist-specific voltage sensitivity at the dopamine D2S receptor--molecular determinants and relevance to therapeutic ligands. , Sahlholm K., Neuropharmacology. January 1, 2011; 61 (5-6): 937-49.
Four and a half LIM protein 1C (FHL1C): a binding partner for voltage-gated potassium channel K( v1.5). , Poparic I., PLoS One. January 1, 2011; 6 (10): e26524.
Inhibition of G protein-activated inwardly rectifying K+ channels by different classes of antidepressants. , Kobayashi T., PLoS One. January 1, 2011; 6 (12): e28208.
Gating of a G protein-sensitive mammalian Kir3.1 prokaryotic Kir channel chimera in planar lipid bilayers. , Leal-Pinto E., J Biol Chem. December 17, 2010; 285 (51): 39790-800.
Inhibition of G-protein-activated inwardly rectifying K+ channels by the selective norepinephrine reuptake inhibitors atomoxetine and reboxetine. , Kobayashi T., Neuropsychopharmacology. June 1, 2010; 35 (7): 1560-9.
Inhibitory effects of the antiepileptic drug ethosuximide on G protein-activated inwardly rectifying K+ channels. , Kobayashi T., Neuropharmacology. February 1, 2009; 56 (2): 499-506.
Characterizations of a loss-of-function mutation in the Kir3.4 channel subunit. , Calloe K., Biochem Biophys Res Commun. December 28, 2007; 364 (4): 889-95.
Inhibition by cocaine of G protein-activated inwardly rectifying K+ channels expressed in Xenopus oocytes. , Kobayashi T., Toxicol In Vitro. June 1, 2007; 21 (4): 656-64.
RGS3 and RGS4 differentially associate with G protein-coupled receptor-Kir3 channel signaling complexes revealing two modes of RGS modulation. Precoupling and collision coupling. , Jaén C., J Biol Chem. November 10, 2006; 281 (45): 34549-60.
Inhibition of G protein-activated inwardly rectifying K+ channels by the antidepressant paroxetine. , Kobayashi T., J Pharmacol Sci. November 1, 2006; 102 (3): 278-87.
Inhibition of G protein-activated inwardly rectifying K+ channels by ifenprodil. , Kobayashi T., Neuropsychopharmacology. March 1, 2006; 31 (3): 516-24.
Mutation of critical GIRK subunit residues disrupts N- and C-termini association and channel function. , Sarac R., J Neurosci. February 16, 2005; 25 (7): 1836-46.
Molecular cloning and characterization of a new RGS protein of Medaka. , Itoh M., Gene. January 31, 2005; 345 (2): 165-71.
RFamide-related peptides signal through the neuropeptide FF receptor and regulate pain-related responses in the rat. , Pertovaara A., Neuroscience. January 1, 2005; 134 (3): 1023-32.
Modulators of G protein-activated inwardly rectifying K+ channels: potentially therapeutic agents for addictive drug users. , Kobayashi T., Ann N Y Acad Sci. October 1, 2004; 1025 590-4.
Inhibition of G protein-activated inwardly rectifying K+ channels by various antidepressant drugs. , Kobayashi T., Neuropsychopharmacology. October 1, 2004; 29 (10): 1841-51.
Molecular determinants responsible for differential cellular distribution of G protein-gated inwardly rectifying K+ channels. , Mirshahi T., J Biol Chem. March 19, 2004; 279 (12): 11890-7.
Mechanosensitivity of GIRK channels is mediated by protein kinase C-dependent channel-phosphatidylinositol 4,5-bisphosphate interaction. , Zhang L., J Biol Chem. February 20, 2004; 279 (8): 7037-47.
Measuring the modulatory effects of RGS proteins on GIRK channels. , Doupnik CA., Methods Enzymol. January 1, 2004; 389 131-54.
Mapping the Gbetagamma-binding sites in GIRK1 and GIRK2 subunits of the G protein-activated K+ channel. , Ivanina T., J Biol Chem. August 1, 2003; 278 (31): 29174-83.
The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. , Brown AJ., J Biol Chem. March 28, 2003; 278 (13): 11312-9.
Inhibition of G protein-activated inwardly rectifying K+ channels by fluoxetine (Prozac). , Kobayashi T., Br J Pharmacol. March 1, 2003; 138 (6): 1119-28.
Early embryonic expression of ion channels and pumps in chick and Xenopus development. , Rutenberg J., Dev Dyn. December 1, 2002; 225 (4): 469-84.
G protein-gated inwardly rectifying potassium channels are targets for volatile anesthetics. , Weigl LG., Mol Pharmacol. August 1, 2001; 60 (2): 282-9.
Identification of G protein-coupled, inward rectifier potassium channel gene products from the rat anterior pituitary gland. , Gregerson KA., Endocrinology. July 1, 2001; 142 (7): 2820-32.
Characterization of heteromultimeric G protein-coupled inwardly rectifying potassium channels of the tunicate tadpole with a unique pore property. , Murata Y., J Biol Chem. May 25, 2001; 276 (21): 18529-39.
Cloning and characterization of G protein-gated inward rectifier K+ channel ( GIRK1) isoforms from heart and brain. , Zhu L., J Mol Neurosci. February 1, 2001; 16 (1): 21-32.
G-protein mediated gating of inward-rectifier K+ channels. , Mark MD., Eur J Biochem. October 1, 2000; 267 (19): 5830-6.
Expression cloning of KCRF, a potassium channel regulatory factor. , Keren-Raifman T., Biochem Biophys Res Commun. August 11, 2000; 274 (3): 852-8.
Heterologous facilitation of G protein-activated K(+) channels by beta-adrenergic stimulation via cAMP-dependent protein kinase. , Müllner C., J Gen Physiol. May 1, 2000; 115 (5): 547-58.
Kir3.1/3.2 encodes an I(KACh)-like current in gastrointestinal myocytes. , Bradley KK., Am J Physiol Gastrointest Liver Physiol. February 1, 2000; 278 (2): G289-96.
Ethanol opens G-protein-activated inwardly rectifying K+ channels. , Kobayashi T., Nat Neurosci. December 1, 1999; 2 (12): 1091-7.
Probing the G-protein regulation of GIRK1 and GIRK4, the two subunits of the KACh channel, using functional homomeric mutants. , Vivaudou M., J Biol Chem. December 12, 1997; 272 (50): 31553-60.
RGS8 accelerates G-protein-mediated modulation of K+ currents. , Saitoh O., Nature. December 4, 1997; 390 (6659): 525-9.
RGS proteins reconstitute the rapid gating kinetics of gbetagamma-activated inwardly rectifying K+ channels. , Doupnik CA., Proc Natl Acad Sci U S A. September 16, 1997; 94 (19): 10461-6.
Activation of heteromeric G protein-gated inward rectifier K+ channels overexpressed by adenovirus gene transfer inhibits the excitability of hippocampal neurons. , Ehrengruber MU., Proc Natl Acad Sci U S A. June 24, 1997; 94 (13): 7070-5.
Cloning and characterization of Kir3.1 ( GIRK1) C-terminal alternative splice variants. , Nelson CS., Brain Res Mol Brain Res. June 1, 1997; 46 (1-2): 185-96.
Inwardly rectifying potassium channels: their molecular heterogeneity and function. , Isomoto S., Jpn J Physiol. February 1, 1997; 47 (1): 11-39.
Control of channel activity through a unique amino acid residue of a G protein-gated inwardly rectifying K+ channel subunit. , Chan KW., Proc Natl Acad Sci U S A. November 26, 1996; 93 (24): 14193-8.
Na+ activation of the muscarinic K+ channel by a G-protein-independent mechanism. , Sui JL., J Gen Physiol. November 1, 1996; 108 (5): 381-91.