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Summary Anatomy Item Literature (14955) Expression Attributions Wiki
XB-ANAT-468

Papers associated with whole organism (and kcnh2)

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The plant-derived alkaloid aloperine prevents ischemia/reperfusion injury-induced sudden cardiac death., Hu Z., FASEB J. July 1, 2023; 37 (7): e22999.


Coupling the Cardiac Voltage-Gated Sodium Channel to Channelrhodopsin-2 Generates Novel Optical Switches for Action Potential Studies., Vom Dahl C., Membranes (Basel). September 20, 2022; 12 (10):


Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer., Levin M., Cell. April 15, 2021;               


Toward a Structural View of hERG Activation by the Small-Molecule Activator ICA-105574., Zangerl-Plessl EM., J Chem Inf Model. January 27, 2020; 60 (1): 360-371.


Non-sedating antihistamines block G-protein-gated inwardly rectifying K+ channels., Chen IS., Br J Pharmacol. September 1, 2019; 176 (17): 3161-3179.


The acute effects of hydrocortisone on cardiac electrocardiography, action potentials, intracellular calcium, and contraction: The role of protein kinase C., Park MH., Mol Cell Endocrinol. August 20, 2019; 494 110488.


Fluorescent analogues of BeKm-1 with high and specific activity against the hERG channel., Vasseur L., Toxicon X. February 23, 2019; 2 100010.        


Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations., Furutani K., J Gen Physiol. February 4, 2019; 151 (2): 214-230.                      


Molecular Basis of Altered hERG1 Channel Gating Induced by Ginsenoside Rg3., Gardner A., Mol Pharmacol. October 1, 2017; 92 (4): 437-450.


Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4., Abbott GW., Sci Rep. December 6, 2016; 6 38412.              


Molecular Cloning and Functional Expression of the Equine K+ Channel KV11.1 (Ether à Go-Go-Related/KCNH2 Gene) and the Regulatory Subunit KCNE2 from Equine Myocardium., Pedersen PJ., PLoS One. September 4, 2015; 10 (9): e0138320.                  


Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes., Liu QN., PLoS One. April 22, 2015; 10 (4): e0123951.                


Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels., Cristofori-Armstrong B., Sci Rep. January 12, 2015; 5 14763.                                


Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels., Ng CA., J Biol Chem. September 12, 2014; 289 (37): 25822-32.


Ginseng gintonin activates the human cardiac delayed rectifier K+ channel: involvement of Ca2+/calmodulin binding sites., Choi SH., Mol Cells. September 1, 2014; 37 (9): 656-63.                


Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics., Lundby A., Nat Methods. August 1, 2014; 11 (8): 868-74.      


The variant hERG/R148W associated with LQTS is a mutation that reduces current density on co-expression with the WT., Mechakra A., Gene. February 25, 2014; 536 (2): 348-56.            


Coxsackievirus B3 modulates cardiac ion channels., Steinke K., FASEB J. October 1, 2013; 27 (10): 4108-21.


Effect of azelastine on cardiac repolarization of guinea-pig cardiomyocytes, hERG K⁺ channel, and human L-type and T-type Ca²⁺ channel., Park MH., J Pharmacol Sci. September 20, 2013; 123 (1): 67-77.


Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels., Perry MD., J Gen Physiol. September 1, 2013; 142 (3): 275-88.                    


VEGFA-dependent and -independent pathways synergise to drive Scl expression and initiate programming of the blood stem cell lineage in Xenopus., Ciau-Uitz A., Development. June 1, 2013; 140 (12): 2632-42.                                                                                                                            


Mechanisms of zolpidem-induced long QT syndrome: acute inhibition of recombinant hERG K(+) channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cells., Jehle J., Br J Pharmacol. March 1, 2013; 168 (5): 1215-29.


Block of hERG K+ channel and prolongation of action potential duration by fluphenazine at submicromolar concentration., Hong HK., Eur J Pharmacol. February 28, 2013; 702 (1-3): 165-73.


Blocking of the human ether-à-go-go-related gene channel by imatinib mesylate., Dong Q., Biol Pharm Bull. January 1, 2013; 36 (2): 268-75.


Kcnh1 voltage-gated potassium channels are essential for early zebrafish development., Stengel R., J Biol Chem. October 12, 2012; 287 (42): 35565-35575.            


Marine algal toxin azaspiracid is an open-state blocker of hERG potassium channels., Twiner MJ., Chem Res Toxicol. September 17, 2012; 25 (9): 1975-84.


Acute alteration of cardiac ECG, action potential, I(Kr) and the human ether-a-go-go-related gene (hERG) K+ channel by PCB 126 and PCB 77., Park MH., Toxicol Appl Pharmacol. July 1, 2012; 262 (1): 60-9.


18β-Glycyrrhetinic acid preferentially blocks late Na current generated by ΔKPQ Nav1.5 channels., Du YM., Acta Pharmacol Sin. June 1, 2012; 33 (6): 752-60.            


Molecular coupling in the human ether-a-go-go-related gene-1 (hERG1) K+ channel inactivation pathway., Ferrer T., J Biol Chem. November 11, 2011; 286 (45): 39091-9.


Effects of the histamine H(1) receptor antagonist hydroxyzine on hERG K(+) channels and cardiac action potential duration., Lee BH., Acta Pharmacol Sin. September 1, 2011; 32 (9): 1128-37.                  


Sig1R protein regulates hERG channel expression through a post-translational mechanism in leukemic cells., Crottès D., J Biol Chem. August 12, 2011; 286 (32): 27947-58.


hERGAPDbase: a database documenting hERG channel inhibitory potentials and APD-prolongation activities of chemical compounds., Hishigaki H., Database (Oxford). May 17, 2011; 2011 bar017.            


Recombinant expression of the toxic peptide ErgTx1 and role of Met35 on its stability and function., Jimenez-Vargas JM., Peptides. March 1, 2011; 32 (3): 560-7.


hERG K+ channel-associated cardiac effects of the antidepressant drug desipramine., Staudacher I., Naunyn Schmiedebergs Arch Pharmacol. February 1, 2011; 383 (2): 119-39.


Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels., Larsen AP., Br J Pharmacol. October 1, 2010; 161 (3): 614-28.


Response of i(kr) and HERG currents to the antipsychotics tiapride and sulpiride., Jo SH., Korean J Physiol Pharmacol. October 1, 2010; 14 (5): 305-10.


Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine., Obers S., Naunyn Schmiedebergs Arch Pharmacol. May 1, 2010; 381 (5): 385-400.


The amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanism., Gessner G., Eur J Pharmacol. April 25, 2010; 632 (1-3): 52-9.


Tel1/ETV6 specifies blood stem cells through the agency of VEGF signaling., Ciau-Uitz A., Dev Cell. April 20, 2010; 18 (4): 569-78.                


Modulation of human ether a gogo related channels by CASQ2 contributes to etiology of catecholaminergic polymorphic ventricular tachycardia (CPVT)., Eckey K., Cell Physiol Biochem. January 1, 2010; 26 (4-5): 503-12.


H(1) antihistamine drug promethazine directly blocks hERG K(+) channel., Jo SH., Pharmacol Res. November 1, 2009; 60 (5): 429-37.


The role of hERG1 K+ channels and a functional link between hERG1 K+ channels and SDF-1 in acute leukemic cell migration., Li H., Exp Cell Res. August 1, 2009; 315 (13): 2256-64.


Extracellular potassium dependency of block of HERG by quinidine and cisapride is primarily determined by the permeant ion and not by inactivation., Barrows B., Channels (Austin). January 1, 2009; 3 (4): 239-48.


Papaverine, a vasodilator, blocks the pore of the HERG channel at submicromolar concentration., Kim YJ., J Cardiovasc Pharmacol. December 1, 2008; 52 (6): 485-93.


Characterization of hERG1a and hERG1b potassium channels-a possible role for hERG1b in the I (Kr) current., Larsen AP., Pflugers Arch. September 1, 2008; 456 (6): 1137-48.


Topological mapping of the asymmetric drug binding to the human ether-à-go-go-related gene product (HERG) potassium channel by use of tandem dimers., Myokai T., Mol Pharmacol. June 1, 2008; 73 (6): 1643-51.


Probing the binding sites and mechanisms of action of two human ether-a-go-go-related gene channel activators, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243)., Xu X., Mol Pharmacol. June 1, 2008; 73 (6): 1709-21.


Chlorthalidone inhibits the KvLQT1 potassium current in guinea-pig ventricular myocytes and oocytes from Xenopus laevis., Mancilla-Simbro C., Br J Pharmacol. February 1, 2008; 153 (3): 448-58.


Extracellular acidification and hyperkalemia induce changes in HERG inhibition by ibutilide., Lin C., Cardiology. January 1, 2008; 110 (3): 209-16.


Cooperative interactions between R531 and acidic residues in the voltage sensing module of hERG1 channels., Piper DR., Cell Physiol Biochem. January 1, 2008; 21 (1-3): 37-46.

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