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Summary Anatomy Item Literature (18807) Expression Attributions Wiki
XB-ANAT-476

Papers associated with cell (and kcnh2)

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Functional and clinical characterization of a novel homozygous KCNH2 missense variant in the pore region of Kv11.1 leading to a viable but severe long-QT syndrome., Delinière A., Gene. March 1, 2024; 897 148076.


The plant-derived alkaloid aloperine prevents ischemia/reperfusion injury-induced sudden cardiac death., Hu Z., FASEB J. July 1, 2023; 37 (7): e22999.


External Cd2+ and protons activate the hyperpolarization-gated K+ channel KAT1 at the voltage sensor., Zhou Y., J Gen Physiol. January 4, 2021; 153 (1):                           


Polyunsaturated fatty acid analogues differentially affect cardiac NaV, CaV, and KV channels through unique mechanisms., Bohannon BM., Elife. March 24, 2020; 9                                                               


Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds., Hull CM., Am J Physiol Regul Integr Comp Physiol. December 1, 2019; 317 (6): R921-R931.


Non-sedating antihistamines block G-protein-gated inwardly rectifying K+ channels., Chen IS., Br J Pharmacol. September 1, 2019; 176 (17): 3161-3179.


Temperature Dependence of the Biophysical Mechanisms Underlying the Inhibition and Enhancement Effect of Amiodarone on hERG Channels., Lo YC., Mol Pharmacol. September 1, 2019; 96 (3): 330-344.


The acute effects of hydrocortisone on cardiac electrocardiography, action potentials, intracellular calcium, and contraction: The role of protein kinase C., Park MH., Mol Cell Endocrinol. August 20, 2019; 494 110488.


Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations., Furutani K., J Gen Physiol. February 4, 2019; 151 (2): 214-230.                      


Nocturnal Atrial Fibrillation Caused by Mutation in KCND2, Encoding Pore-Forming (α) Subunit of the Cardiac Kv4.2 Potassium Channel., Drabkin M., Circ Genom Precis Med. November 1, 2018; 11 (11): e002293.


Two mutations at different positions in the CNBH domain of the hERG channel accelerate deactivation and impair the interaction with the EAG domain., Kume S., J Physiol. October 1, 2018; 596 (19): 4629-4650.


Functional characterization of Kv11.1 (hERG) potassium channels split in the voltage-sensing domain., de la Peña P., Pflugers Arch. July 1, 2018; 470 (7): 1069-1085.                


Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo., Baburin I., Pharmacol Res. May 1, 2018; 131 150-163.


Dynamic rearrangement of the intrinsic ligand regulates KCNH potassium channels., Dai G., J Gen Physiol. April 2, 2018; 150 (4): 625-635.            


The Fast Component of hERG Gating Charge: An Interaction between D411 in the S1 and S4 Residues., Dou Y., Biophys J. November 7, 2017; 113 (9): 1979-1991.


APETx4, a Novel Sea Anemone Toxin and a Modulator of the Cancer-Relevant Potassium Channel KV10.1., Moreels L., Mar Drugs. September 13, 2017; 15 (9):                 


Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4., Abbott GW., Sci Rep. December 6, 2016; 6 38412.              


Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes., Liu QN., PLoS One. April 22, 2015; 10 (4): e0123951.                


Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains., Lörinczi É., Nat Commun. March 30, 2015; 6 6672.                    


High incidence of functional ion-channel abnormalities in a consecutive Long QT cohort with novel missense genetic variants of unknown significance., Steffensen AB., Sci Rep. January 12, 2015; 5 10009.              


Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels., Cristofori-Armstrong B., Sci Rep. January 12, 2015; 5 14763.                                


Concatenated hERG1 tetramers reveal stoichiometry of altered channel gating by RPR-260243., Wu W., Mol Pharmacol. January 1, 2015; 87 (3): 401-9.


Ginseng gintonin activates the human cardiac delayed rectifier K+ channel: involvement of Ca2+/calmodulin binding sites., Choi SH., Mol Cells. September 1, 2014; 37 (9): 656-63.                


Concerted all-or-none subunit interactions mediate slow deactivation of human ether-à-go-go-related gene K+ channels., Thomson SJ., J Biol Chem. August 22, 2014; 289 (34): 23428-36.


The variant hERG/R148W associated with LQTS is a mutation that reduces current density on co-expression with the WT., Mechakra A., Gene. February 25, 2014; 536 (2): 348-56.            


Up-regulation of hERG K⁺ channels by B-RAF., Pakladok T., PLoS One. January 1, 2014; 9 (1): e87457.          


Up-regulation of Kir2.1 (KCNJ2) by the serum & glucocorticoid inducible SGK3., Munoz C., Cell Physiol Biochem. January 1, 2014; 33 (2): 491-500.


Chimeric hERG channels containing a tetramerization domain are functional and stable., Hausammann GJ., Biochemistry. December 23, 2013; 52 (51): 9237-45.


Coxsackievirus B3 modulates cardiac ion channels., Steinke K., FASEB J. October 1, 2013; 27 (10): 4108-21.


Effect of azelastine on cardiac repolarization of guinea-pig cardiomyocytes, hERG K⁺ channel, and human L-type and T-type Ca²⁺ channel., Park MH., J Pharmacol Sci. September 20, 2013; 123 (1): 67-77.


Klotho sensitivity of the hERG channel., Munoz C., FEBS Lett. June 5, 2013; 587 (11): 1663-8.


VEGFA-dependent and -independent pathways synergise to drive Scl expression and initiate programming of the blood stem cell lineage in Xenopus., Ciau-Uitz A., Development. June 1, 2013; 140 (12): 2632-42.                                                                                                                            


External pH modulates EAG superfamily K+ channels through EAG-specific acidic residues in the voltage sensor., Kazmierczak M., J Gen Physiol. June 1, 2013; 141 (6): 721-35.                        


Mechanisms of zolpidem-induced long QT syndrome: acute inhibition of recombinant hERG K(+) channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cells., Jehle J., Br J Pharmacol. March 1, 2013; 168 (5): 1215-29.


Block of hERG K+ channel and prolongation of action potential duration by fluphenazine at submicromolar concentration., Hong HK., Eur J Pharmacol. February 28, 2013; 702 (1-3): 165-73.


Blocking of the human ether-à-go-go-related gene channel by imatinib mesylate., Dong Q., Biol Pharm Bull. January 1, 2013; 36 (2): 268-75.


PIKfyve sensitivity of hERG channels., Pakladok T., Cell Physiol Biochem. January 1, 2013; 31 (6): 785-94.


Impaired ion channel function related to a common KCNQ1 mutation - implications for risk stratification in long QT syndrome 1., Aidery P., Gene. December 10, 2012; 511 (1): 26-33.        


A natural point mutation changes both target selectivity and mechanism of action of sea anemone toxins., Peigneur S., FASEB J. December 1, 2012; 26 (12): 5141-51.


Kcnh1 voltage-gated potassium channels are essential for early zebrafish development., Stengel R., J Biol Chem. October 12, 2012; 287 (42): 35565-35575.            


Tuning of EAG K(+) channel inactivation: molecular determinants of amplification by mutations and a small molecule., Garg V., J Gen Physiol. September 1, 2012; 140 (3): 307-24.                            


Inhibition of cardiac Kir2.1-2.3 channels by beta3 adrenoreceptor antagonist SR 59230A., Kulzer M., Biochem Biophys Res Commun. July 27, 2012; 424 (2): 315-20.


Acute alteration of cardiac ECG, action potential, I(Kr) and the human ether-a-go-go-related gene (hERG) K+ channel by PCB 126 and PCB 77., Park MH., Toxicol Appl Pharmacol. July 1, 2012; 262 (1): 60-9.


18β-Glycyrrhetinic acid preferentially blocks late Na current generated by ΔKPQ Nav1.5 channels., Du YM., Acta Pharmacol Sin. June 1, 2012; 33 (6): 752-60.            


Stimulation of HERG channel activity by β-catenin., Munoz C., PLoS One. January 1, 2012; 7 (8): e43353.          


Effects of the histamine H(1) receptor antagonist hydroxyzine on hERG K(+) channels and cardiac action potential duration., Lee BH., Acta Pharmacol Sin. September 1, 2011; 32 (9): 1128-37.                  


Ginsenoside Rg(3) decelerates hERG K(+) channel deactivation through Ser631 residue interaction., Choi SH., Eur J Pharmacol. August 1, 2011; 663 (1-3): 59-67.


A bifunctional sea anemone peptide with Kunitz type protease and potassium channel inhibiting properties., Peigneur S., Biochem Pharmacol. July 1, 2011; 82 (1): 81-90.


Differential effects of ginsenoside metabolites on HERG k channel currents., Choi SH., J Ginseng Res. June 1, 2011; 35 (2): 191-9.        


hERGAPDbase: a database documenting hERG channel inhibitory potentials and APD-prolongation activities of chemical compounds., Hishigaki H., Database (Oxford). May 17, 2011; 2011 bar017.            

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