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Summary Anatomy Item Literature (3673) Expression Attributions Wiki
XB-ANAT-490

Papers associated with tail (and kcnh2)

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Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer., Levin M., Cell. April 15, 2021;               


External Cd2+ and protons activate the hyperpolarization-gated K+ channel KAT1 at the voltage sensor., Zhou Y., J Gen Physiol. January 4, 2021; 153 (1):                           


Polyunsaturated fatty acid analogues differentially affect cardiac NaV, CaV, and KV channels through unique mechanisms., Bohannon BM., Elife. March 24, 2020; 9                                                               


Regulation of Eag1 gating by its intracellular domains., Whicher JR., Elife. September 6, 2019; 8                     


The molecular determinants of R-roscovitine block of hERG channels., Cernuda B., PLoS One. September 3, 2019; 14 (9): e0217733.                      


Temperature Dependence of the Biophysical Mechanisms Underlying the Inhibition and Enhancement Effect of Amiodarone on hERG Channels., Lo YC., Mol Pharmacol. September 1, 2019; 96 (3): 330-344.


Identification of undecylenic acid as EAG channel inhibitor using surface plasmon resonance-based screen of KCNH channels., Wang ZJ., BMC Pharmacol Toxicol. July 17, 2019; 20 (1): 42.                        


Importance of the Choice of a Recombinant System to Produce Large Amounts of Functional Membrane Protein hERG., Vasseur L., Int J Mol Sci. June 28, 2019; 20 (13):           


ANK2 functionally interacts with KCNH2 aggravating long QT syndrome in a double mutation carrier., Gessner G., Biochem Biophys Res Commun. May 14, 2019; 512 (4): 845-851.    


Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations., Furutani K., J Gen Physiol. February 4, 2019; 151 (2): 214-230.                      


Bipolar switching by HCN voltage sensor underlies hyperpolarization activation., Cowgill J., Proc Natl Acad Sci U S A. January 8, 2019; 116 (2): 670-678.                        


Functional characterization of Kv11.1 (hERG) potassium channels split in the voltage-sensing domain., de la Peña P., Pflugers Arch. July 1, 2018; 470 (7): 1069-1085.                


Dynamic rearrangement of the intrinsic ligand regulates KCNH potassium channels., Dai G., J Gen Physiol. April 2, 2018; 150 (4): 625-635.            


Investigating the state dependence of drug binding in hERG channels using a trapped-open channel phenotype., Thouta S., Sci Rep. March 21, 2018; 8 (1): 4962.        


Probing the molecular basis of hERG drug block with unnatural amino acids., Macdonald LC., Sci Rep. January 10, 2018; 8 (1): 289.              


APETx4, a Novel Sea Anemone Toxin and a Modulator of the Cancer-Relevant Potassium Channel KV10.1., Moreels L., Mar Drugs. September 13, 2017; 15 (9):                 


Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4., Abbott GW., Sci Rep. December 6, 2016; 6 38412.              


Mitragynine and its potential blocking effects on specific cardiac potassium channels., Tay YL., Toxicol Appl Pharmacol. August 15, 2016; 305 22-39.


Molecular Cloning and Functional Expression of the Equine K+ Channel KV11.1 (Ether à Go-Go-Related/KCNH2 Gene) and the Regulatory Subunit KCNE2 from Equine Myocardium., Pedersen PJ., PLoS One. September 4, 2015; 10 (9): e0138320.                  


HPLC-Based Activity Profiling for hERG Channel Inhibitors in the South African Medicinal Plant Galenia africana., Du K., Planta Med. August 1, 2015; 81 (12-13): 1154-62.


Interactions between the N-terminal tail and the gating machinery of hERG K⁺ channels both in closed and open/inactive states., de la Peña P., Pflugers Arch. August 1, 2015; 467 (8): 1747-56.


hERG Channel Inhibitory Daphnane Diterpenoid Orthoesters and Polycephalones A and B with Unprecedented Skeletons from Gnidia polycephala., De Mieri M., J Nat Prod. July 24, 2015; 78 (7): 1697-707.


Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes., Liu QN., PLoS One. April 22, 2015; 10 (4): e0123951.                


Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains., Lörinczi É., Nat Commun. March 30, 2015; 6 6672.                    


Anesthetic drug midazolam inhibits cardiac human ether-à-go-go-related gene channels: mode of action., Vonderlin N., Drug Des Devel Ther. February 16, 2015; 9 867-77.              


High incidence of functional ion-channel abnormalities in a consecutive Long QT cohort with novel missense genetic variants of unknown significance., Steffensen AB., Sci Rep. January 12, 2015; 5 10009.              


Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels., Cristofori-Armstrong B., Sci Rep. January 12, 2015; 5 14763.                                


Ginseng gintonin activates the human cardiac delayed rectifier K+ channel: involvement of Ca2+/calmodulin binding sites., Choi SH., Mol Cells. September 1, 2014; 37 (9): 656-63.                


Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics., Lundby A., Nat Methods. August 1, 2014; 11 (8): 868-74.      


A functional Kv1.2-hERG chimaeric channel expressed in Pichia pastoris., Dhillon MS., Sci Rep. February 26, 2014; 4 4201.              


Up-regulation of hERG K⁺ channels by B-RAF., Pakladok T., PLoS One. January 1, 2014; 9 (1): e87457.          


The Eag domain regulates the voltage-dependent inactivation of rat Eag1 K+ channels., Lin TF., PLoS One. January 1, 2014; 9 (10): e110423.                  


AMP-activated protein kinase regulates hERG potassium channel., Almilaji A., Pflugers Arch. November 1, 2013; 465 (11): 1573-82.


C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels., Ng CA., PLoS One. October 4, 2013; 8 (10): e77032.            


Effect of azelastine on cardiac repolarization of guinea-pig cardiomyocytes, hERG K⁺ channel, and human L-type and T-type Ca²⁺ channel., Park MH., J Pharmacol Sci. September 20, 2013; 123 (1): 67-77.


Functional interactions of voltage sensor charges with an S2 hydrophobic plug in hERG channels., Cheng YM., J Gen Physiol. September 1, 2013; 142 (3): 289-303.                


VEGFA-dependent and -independent pathways synergise to drive Scl expression and initiate programming of the blood stem cell lineage in Xenopus., Ciau-Uitz A., Development. June 1, 2013; 140 (12): 2632-42.                                                                                                                            


External pH modulates EAG superfamily K+ channels through EAG-specific acidic residues in the voltage sensor., Kazmierczak M., J Gen Physiol. June 1, 2013; 141 (6): 721-35.                        


Mapping of interactions between the N- and C-termini and the channel core in HERG K+ channels., de la Peña P., Biochem J. May 1, 2013; 451 (3): 463-74.


Block of hERG K+ channel and prolongation of action potential duration by fluphenazine at submicromolar concentration., Hong HK., Eur J Pharmacol. February 28, 2013; 702 (1-3): 165-73.


The eag domain regulates hERG channel inactivation gating via a direct interaction., Gustina AS., J Gen Physiol. February 1, 2013; 141 (2): 229-41.                  


Impaired ion channel function related to a common KCNQ1 mutation - implications for risk stratification in long QT syndrome 1., Aidery P., Gene. December 10, 2012; 511 (1): 26-33.        


Kcnh1 voltage-gated potassium channels are essential for early zebrafish development., Stengel R., J Biol Chem. October 12, 2012; 287 (42): 35565-35575.            


Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels., Tan PS., J Gen Physiol. September 1, 2012; 140 (3): 293-306.                


Identification and functional characterization of the novel human ether-a-go-go-related gene (hERG) R744P mutant associated with hereditary long QT syndrome 2., Aidery P., Biochem Biophys Res Commun. February 24, 2012; 418 (4): 830-5.


Stimulation of HERG channel activity by β-catenin., Munoz C., PLoS One. January 1, 2012; 7 (8): e43353.          


A molecular switch driving inactivation in the cardiac K+ channel HERG., Köpfer DA., PLoS One. January 1, 2012; 7 (7): e41023.          


Effects of the histamine H(1) receptor antagonist hydroxyzine on hERG K(+) channels and cardiac action potential duration., Lee BH., Acta Pharmacol Sin. September 1, 2011; 32 (9): 1128-37.                  


Ginsenoside Rg(3) decelerates hERG K(+) channel deactivation through Ser631 residue interaction., Choi SH., Eur J Pharmacol. August 1, 2011; 663 (1-3): 59-67.


Differential effects of ginsenoside metabolites on HERG k channel currents., Choi SH., J Ginseng Res. June 1, 2011; 35 (2): 191-9.        

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