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Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR. , Sempou E., Nat Commun. November 5, 2022; 13 (1): 6681.
External Cd2+ and protons activate the hyperpolarization-gated K+ channel KAT1 at the voltage sensor. , Zhou Y., J Gen Physiol. January 4, 2021; 153 (1):
Chlorpromazine binding to the PAS domains uncovers the effect of ligand modulation on EAG channel activity. , Wang ZJ., J Biol Chem. March 27, 2020; 295 (13): 4114-4123.
Regulation of Eag1 gating by its intracellular domains. , Whicher JR., Elife. September 6, 2019; 8
Identification of undecylenic acid as EAG channel inhibitor using surface plasmon resonance-based screen of KCNH channels. , Wang ZJ., BMC Pharmacol Toxicol. July 17, 2019; 20 (1): 42.
Bipolar switching by HCN voltage sensor underlies hyperpolarization activation. , Cowgill J., Proc Natl Acad Sci U S A. January 8, 2019; 116 (2): 670-678.
Dynamic rearrangement of the intrinsic ligand regulates KCNH potassium channels. , Dai G., J Gen Physiol. April 2, 2018; 150 (4): 625-635.
Molecular mechanism of voltage-dependent potentiation of KCNH potassium channels. , Dai G., Elife. April 27, 2017; 6
Calmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology Domain. , Lörinczi E., J Biol Chem. August 19, 2016; 291 (34): 17907-18.
Mitragynine and its potential blocking effects on specific cardiac potassium channels. , Tay YL., Toxicol Appl Pharmacol. August 15, 2016; 305 22-39.
HPLC-Based Activity Profiling for hERG Channel Inhibitors in the South African Medicinal Plant Galenia africana. , Du K., Planta Med. August 1, 2015; 81 (12-13): 1154-62.
Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. , Liu QN., PLoS One. April 22, 2015; 10 (4): e0123951.
Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels. , Cristofori-Armstrong B., Sci Rep. January 12, 2015; 5 14763.
Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy. , Simons C., Nat Genet. January 1, 2015; 47 (1): 73-7.
Up-regulation of hERG K⁺ channels by B-RAF. , Pakladok T., PLoS One. January 1, 2014; 9 (1): e87457.
The Eag domain regulates the voltage-dependent inactivation of rat Eag1 K+ channels. , Lin TF., PLoS One. January 1, 2014; 9 (10): e110423.
AMP-activated protein kinase regulates hERG potassium channel. , Almilaji A., Pflugers Arch. November 1, 2013; 465 (11): 1573-82.
Effect of azelastine on cardiac repolarization of guinea-pig cardiomyocytes, hERG K⁺ channel, and human L-type and T-type Ca²⁺ channel. , Park MH., J Pharmacol Sci. September 20, 2013; 123 (1): 67-77.
External pH modulates EAG superfamily K+ channels through EAG-specific acidic residues in the voltage sensor. , Kazmierczak M., J Gen Physiol. June 1, 2013; 141 (6): 721-35.
Mapping of interactions between the N- and C-termini and the channel core in HERG K+ channels. , de la Peña P., Biochem J. May 1, 2013; 451 (3): 463-74.
Flavonoid regulation of EAG1 channels. , Carlson AE., J Gen Physiol. March 1, 2013; 141 (3): 347-58.
Block of hERG K+ channel and prolongation of action potential duration by fluphenazine at submicromolar concentration. , Hong HK., Eur J Pharmacol. February 28, 2013; 702 (1-3): 165-73.
The eag domain regulates hERG channel inactivation gating via a direct interaction. , Gustina AS., J Gen Physiol. February 1, 2013; 141 (2): 229-41.
Impaired ion channel function related to a common KCNQ1 mutation - implications for risk stratification in long QT syndrome 1. , Aidery P., Gene. December 10, 2012; 511 (1): 26-33.
Kcnh1 voltage-gated potassium channels are essential for early zebrafish development. , Stengel R., J Biol Chem. October 12, 2012; 287 (42): 35565-35575.
Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels. , Tan PS., J Gen Physiol. September 1, 2012; 140 (3): 293-306.
Identification and functional characterization of the novel human ether-a- go-go-related gene ( hERG) R744P mutant associated with hereditary long QT syndrome 2. , Aidery P., Biochem Biophys Res Commun. February 24, 2012; 418 (4): 830-5.
Effects of the histamine H(1) receptor antagonist hydroxyzine on hERG K(+) channels and cardiac action potential duration. , Lee BH., Acta Pharmacol Sin. September 1, 2011; 32 (9): 1128-37.
Ginsenoside Rg(3) decelerates hERG K(+) channel deactivation through Ser631 residue interaction. , Choi SH., Eur J Pharmacol. August 1, 2011; 663 (1-3): 59-67.
Differential effects of ginsenoside metabolites on HERG k channel currents. , Choi SH., J Ginseng Res. June 1, 2011; 35 (2): 191-9.
Fluorescence-tracking of activation gating in human ERG channels reveals rapid S4 movement and slow pore opening. , Es-Salah-Lamoureux Z., PLoS One. May 3, 2010; 5 (5): e10876.
Transfer of ion binding site from ether-a- go-go to Shaker: Mg2+ binds to resting state to modulate channel opening. , Lin MC., J Gen Physiol. May 1, 2010; 135 (5): 415-31.
Block of the human ether-a- go-go-related gene ( hERG) K+ channel by the antidepressant desipramine. , Hong HK., Biochem Biophys Res Commun. April 9, 2010; 394 (3): 536-41.
Inhibition of the human ether-a- go-go-related gene ( HERG) K+ channels by Lindera erythrocarpa. , Hong HK., J Korean Med Sci. December 1, 2009; 24 (6): 1089-98.
A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels. , Gustina AS., Proc Natl Acad Sci U S A. August 4, 2009; 106 (31): 13082-7.
Block of HERG k channel by classic histamine h(1) receptor antagonist chlorpheniramine. , Hong HK., Korean J Physiol Pharmacol. June 1, 2009; 13 (3): 215-20.
Blockade of the human ether-a- go-go-related gene potassium channel by ketanserin. , Tu DN., Sheng Li Xue Bao. August 25, 2008; 60 (4): 525-34.
Maprotiline block of the human ether-a- go-go-related gene ( HERG) K+ channel. , Jo SH., Arch Pharm Res. April 1, 2007; 30 (4): 453-60.
Structural requirements of human ether-a- go-go-related gene channels for block by bupivacaine. , Siebrands CC., Anesthesiology. March 1, 2007; 106 (3): 523-31.
Blockade of HERG human K+ channels and IKr of guinea-pig cardiomyocytes by the antipsychotic drug clozapine. , Lee SY., Br J Pharmacol. June 1, 2006; 148 (4): 499-509.
Chemical modification of the human ether-a- go-go-related gene ( HERG) K+ current by the amino-group reagent trinitrobenzene sulfonic acid. , Jo SH., Arch Pharm Res. April 1, 2006; 29 (4): 310-7.
The effects of sevoflurane and propofol on QT interval and heterologously expressed human ether-a- go-go related gene currents in Xenopus oocytes. , Yamada M., Anesth Analg. January 1, 2006; 102 (1): 98-103.
Activation of human ether-a- go-go-related gene potassium channels by the diphenylurea 1,3- bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643). , Hansen RS., Mol Pharmacol. January 1, 2006; 69 (1): 266-77.
Inhibitory effect of rhynchophylline on human ether-a- go-go related gene channel. , Gui L., Sheng Li Xue Bao. October 25, 2005; 57 (5): 648-52.
Inhibition of human ether-a- go-go-related gene K+ channel and IKr of guinea pig cardiomyocytes by antipsychotic drug trifluoperazine. , Choi SY., J Pharmacol Exp Ther. May 1, 2005; 313 (2): 888-95.
A mechanism for the potential proarrhythmic effect of acidosis, bradycardia, and hypokalemia on the blockade of human ether-a- go-go-related gene ( HERG) channels. , Lin C., Am J Ther. January 1, 2005; 12 (4): 328-36.
Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels. , Craven KB., J Gen Physiol. December 1, 2004; 124 (6): 663-77.
Gating charges in the activation and inactivation processes of the HERG channel. , Zhang M., J Gen Physiol. December 1, 2004; 124 (6): 703-18.
Molecular determinants for high-affinity block of human EAG potassium channels by antiarrhythmic agents. , Gessner G., Mol Pharmacol. May 1, 2004; 65 (5): 1120-9.
Negative charges in the transmembrane domains of the HERG K channel are involved in the activation- and deactivation-gating processes. , Liu J ., J Gen Physiol. June 1, 2003; 121 (6): 599-614.