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Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. , Liu QN., PLoS One. April 22, 2015; 10 (4): e0123951.
Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels. , Ng CA., J Biol Chem. September 12, 2014; 289 (37): 25822-32.
Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels. , Perry MD ., J Gen Physiol. September 1, 2013; 142 (3): 275-88.
VEGFA-dependent and -independent pathways synergise to drive Scl expression and initiate programming of the blood stem cell lineage in Xenopus. , Ciau-Uitz A ., Development. June 1, 2013; 140 (12): 2632-42.
Blocking of the human ether-à- go-go-related gene channel by imatinib mesylate. , Dong Q., Biol Pharm Bull. January 1, 2013; 36 (2): 268-75.
Kcnh1 voltage-gated potassium channels are essential for early zebrafish development. , Stengel R., J Biol Chem. October 12, 2012; 287 (42): 35565-35575.
Molecular coupling in the human ether-a- go-go-related gene-1 ( hERG1) K+ channel inactivation pathway. , Ferrer T., J Biol Chem. November 11, 2011; 286 (45): 39091-9.
Sig1R protein regulates hERG channel expression through a post-translational mechanism in leukemic cells. , Crottès D., J Biol Chem. August 12, 2011; 286 (32): 27947-58.
hERG K+ channel-associated cardiac effects of the antidepressant drug desipramine. , Staudacher I., Naunyn Schmiedebergs Arch Pharmacol. February 1, 2011; 383 (2): 119-39.
Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels. , Larsen AP., Br J Pharmacol. October 1, 2010; 161 (3): 614-28.
Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine. , Obers S., Naunyn Schmiedebergs Arch Pharmacol. May 1, 2010; 381 (5): 385-400.
The amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanism. , Gessner G., Eur J Pharmacol. April 25, 2010; 632 (1-3): 52-9.
Tel1/ ETV6 specifies blood stem cells through the agency of VEGF signaling. , Ciau-Uitz A ., Dev Cell. April 20, 2010; 18 (4): 569-78.
Modulation of human ether a gogo related channels by CASQ2 contributes to etiology of catecholaminergic polymorphic ventricular tachycardia (CPVT). , Eckey K., Cell Physiol Biochem. January 1, 2010; 26 (4-5): 503-12.
Extracellular potassium dependency of block of HERG by quinidine and cisapride is primarily determined by the permeant ion and not by inactivation. , Barrows B., Channels (Austin). January 1, 2009; 3 (4): 239-48.
Characterization of hERG1a and hERG1b potassium channels-a possible role for hERG1b in the I (Kr) current. , Larsen AP., Pflugers Arch. September 1, 2008; 456 (6): 1137-48.
Topological mapping of the asymmetric drug binding to the human ether-à- go-go-related gene product ( HERG) potassium channel by use of tandem dimers. , Myokai T., Mol Pharmacol. June 1, 2008; 73 (6): 1643-51.
Extracellular acidification and hyperkalemia induce changes in HERG inhibition by ibutilide. , Lin C., Cardiology. January 1, 2008; 110 (3): 209-16.
Cooperative interactions between R531 and acidic residues in the voltage sensing module of hERG1 channels. , Piper DR., Cell Physiol Biochem. January 1, 2008; 21 (1-3): 37-46.
Zebrafish model for human long QT syndrome. , Arnaout R., Proc Natl Acad Sci U S A. July 3, 2007; 104 (27): 11316-21.
Upregulation of KCNE1 induces QT interval prolongation in patients with chronic heart failure. , Watanabe E., Circ J. April 1, 2007; 71 (4): 471-8.
Expression and functional characterization of the human ether-à- go-go-related gene ( HERG) K+ channel cardiac splice variant in Xenopus laevis oocytes. , Aydar E., J Membr Biol. January 1, 2006; 211 (2): 115-26.
In vivo targeting of ERG potassium channels in mice and dogs by a positron-emitting analogue of fluoroclofilium. , Kim SW., Exp Mol Med. August 31, 2005; 37 (4): 269-75.
Block of wild-type and inactivation-deficient human ether-a- go-go-related gene K+ channels by halofantrine. , Sánchez-Chapula JA., Naunyn Schmiedebergs Arch Pharmacol. December 1, 2004; 370 (6): 484-91.
Activation of cardiac human ether-a- go-go related gene potassium currents is regulated by alpha(1A)-adrenoceptors. , Thomas D., J Mol Med (Berl). December 1, 2004; 82 (12): 826-37.
Identification and characterisation of a novel KCNQ1 mutation in a family with Romano-Ward syndrome. , Zehelein J., Biochim Biophys Acta. November 5, 2004; 1690 (3): 185-92.
Inhibition of human ether-a- go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin. , Thomas D., Naunyn Schmiedebergs Arch Pharmacol. May 1, 2004; 369 (5): 462-72.
Physicochemical features of the HERG channel drug binding site. , Fernandez D., J Biol Chem. March 12, 2004; 279 (11): 10120-7.
Acute effects of dronedarone on both components of the cardiac delayed rectifier K+ current, HERG and KvLQT1/ minK potassium channels. , Thomas D., Br J Pharmacol. November 1, 2003; 140 (5): 996-1002.
The antipsychotic drug chlorpromazine inhibits HERG potassium channels. , Thomas D., Br J Pharmacol. June 1, 2003; 139 (3): 567-74.
Cloning and functional characterization of the smooth muscle ether-a- go-go-related gene K+ channel. Potential role of a conserved amino acid substitution in the S4 region. , Shoeb F., J Biol Chem. January 24, 2003; 278 (4): 2503-14.
Interaction with GM130 during HERG ion channel trafficking. Disruption by type 2 congenital long QT syndrome mutations. Human Ether-à- go-go-Related Gene. , Roti EC., J Biol Chem. December 6, 2002; 277 (49): 47779-85.
Fenamate-induced enhancement of heterologously expressed HERG currents in Xenopus oocytes. , Malykhina AP., Eur J Pharmacol. October 11, 2002; 452 (3): 269-77.
KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current. , Angelo K., Biophys J. October 1, 2002; 83 (4): 1997-2006.
Histidines 578 and 587 in the S5-S6 linker of the human Ether-a-gogo Related Gene-1 K+ channels confer sensitivity to reactive oxygen species. , Pannaccione A., J Biol Chem. March 15, 2002; 277 (11): 8912-9.
[Cardiotoxicity of lindane, a gamma isomer of hexachlorocyclohexane]. , Sauviat MP., J Soc Biol. January 1, 2002; 196 (4): 339-48.
Molecular cloning and expression of cERG, the ether à go-go-related gene from canine myocardium. , Zehelein J., Pflugers Arch. May 1, 2001; 442 (2): 188-91.
Short- and long-term effects of amiodarone on the two components of cardiac delayed rectifier K(+) current. , Kamiya K., Circulation. March 6, 2001; 103 (9): 1317-24.
Antiarrhythmic drug carvedilol inhibits HERG potassium channels. , Karle CA., Cardiovasc Res. February 1, 2001; 49 (2): 361-70.
Inhibition of IKs channels by HMR 1556. , Gögelein H., Naunyn Schmiedebergs Arch Pharmacol. December 1, 2000; 362 (6): 480-8.
Preclinical pharmacology of desloratadine, a selective and nonsedating histamine H1 receptor antagonist. 2nd communication: lack of central nervous system and cardiovascular effects. , Kreutner W., Arzneimittelforschung. May 1, 2000; 50 (5): 441-8.
KChAP as a chaperone for specific K(+) channels. , Kuryshev YA., Am J Physiol Cell Physiol. May 1, 2000; 278 (5): C931-41.
The distinct HERG missense mutation L564P causes long QT syndrome in one French Canadian family. , St-Pierre J., Can J Cardiol. March 1, 2000; 16 (3): 307-12.
Functional analysis of a mouse brain Elk-type K+ channel. , Trudeau MC., J Neurosci. April 15, 1999; 19 (8): 2906-18.
HERG potassium channel activation is shifted by phorbol esters via protein kinase A-dependent pathways. , Kiehn J., J Biol Chem. September 25, 1998; 273 (39): 25285-91.
Blockade of HERG and Kv1.5 by ketoconazole. , Dumaine R., J Pharmacol Exp Ther. August 1, 1998; 286 (2): 727-35.
Differential effects of bupivacaine on cardiac K channels: role of channel inactivation and subunit composition in drug-channel interaction. , Lipka LJ., J Cardiovasc Electrophysiol. July 1, 1998; 9 (7): 727-42.
herg encodes a K+ current highly conserved in tumors of different histogenesis: a selective advantage for cancer cells? , Bianchi L., Cancer Res. February 15, 1998; 58 (4): 815-22.
Blockade of HERG channels by the class III antiarrhythmic azimilide: mode of action. , Busch AE., Br J Pharmacol. January 1, 1998; 123 (1): 23-30.
Two isoforms of the mouse ether-a- go-go-related gene coassemble to form channels with properties similar to the rapidly activating component of the cardiac delayed rectifier K+ current. , London B., Circ Res. November 1, 1997; 81 (5): 870-8.