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XB-IMG-1682

Xenbase Image ID: 1682


Figure 6. Effects of FoxN3 depletion on neural crest formation. Embryos were unilaterally injected with 13 ng FoxN3-MO and 500 pg GFP RNA. After sorting for right/left injections, embryos were submitted at different developmental stages to in situ whole mount hybridization. The asterisks indicate the side of injection. A: FoxD3, stage 23. B:AP2 alpha , stage 23. C:snail, stage 23. D:AP2 alpha , stage 29. E:snail, stage 29. No difference in the expression domains between injected and uninjected sides can be observed. F,G: Whole mount in situ hybridization of unilaterally injected embryos stained for HoxA2 (F) and Sox3 (G). Embryos were injected at their right sides. H-K: Whole mount in situ hybridization of bilaterally FoxN3-MO or Co-MO-injected embryos (13 ng pro blastomere). H:Xbap, Co-MO-injected, stage 38. I:Xbap, FoxN3-MO injected, stage 38. Xbap expression is visible close to the cement gland in the controls (see arrow). The FoxN3-MO-injected embryos show reduced expression of Xbap in the prospective jaw (see arrow). The ventral part of this expression domain is completely absent. J:Xbap, Co-MO-injected, stage 43, ventral view. K:Xbap, FoxN3-MO-injected, stage 43, ventral view. The Xbap expression in the controls is restricted at stage 43 within the head to Meckel's cartilage. FoxN3-MO-injected embryos show severe reduction of staining (see arrows).

Image published in: Schuff M et al. (2007)

Copyright © 2007. Image reproduced with permission of the Publisher, John Wiley & Sons.

GeneSynonymsSpeciesStage(s)Tissue
snai1.SxSna, snail, sna, Xsnail, snail1X.laevisThroughout NF stage 23neural crest
neural plate
tfap2a.LXAP-2, AP-2, tfap2alpha, ap2, xap2, AP2alpha, AP2a, tfap2a-a, tfap2a-bX.laevisThroughout NF stage 23periocular region
cranial neural crest
sox3.SxSox3, Sry, Xtsox3, Xlsox3X.laevisSometime during NF stage 28 to NF stage 32otic vesicle
olfactory placode
lateral line placode
lens
brain
mandibular crest
hyoid crest
anterior branchial crest
posterior branchial crest
intermediate mesoderm
cranial placode
hoxa2.Lhoxa2b, X-Hoxa2, hox1k, hoxa2-a, hoxa2-bX.laevisSometime during NF stage 28 to NF stage 32hindbrain
mandibular crest
hyoid crest
posterior branchial crest
anterior branchial crest
nkx3-2.SXbap, bapx1, bagpipe homeobox homolog 1, nkx3.2X.laevisSometime during NF stage 37 and 38 to NF stage 43pharyngeal arch
foregut
lateral plate mesoderm
cartilage tissue
Meckel's cartilage
optic vesicle
foxd3.LXFD-6, xfoxd3, fkh6, foxd3-a, foxd3-bX.laevisThroughout NF stage 23cranial neural crest
neural crest
eye primordium
snai1.SxSna, snail, sna, Xsnail, snail1X.laevisThroughout NF stage 23cranial neural crest
neural plate border
eye primordium
tfap2a.LXAP-2, AP-2, tfap2alpha, ap2, xap2, AP2alpha, AP2a, tfap2a-a, tfap2a-bX.laevisThroughout NF stage 29 and 30cranial neural crest
periocular region
head mesenchyme
snai1.SxSna, snail, sna, Xsnail, snail1X.laevisThroughout NF stage 29 and 30eye primordium
brain
cranial neural crest

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