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Figure 6. Semaphorin expression in the mesoderm and notochord at tadpole stages. In situ hybridization of the whole embryo (left), dashed line indicates the plane of the transverse section (right). A: Sema3A is expressed in the somites and the splanchnic mesoderm. B: Sema4B expression in the mesoderm is replaced by pronephros, cement gland, otic placode, proctodeum, spinal cord, and gut expression. C: Sema6B is expressed in the somites and otic placode at late neurula stages. D: At tadpole stages, the somite expression is limited to the dorsal and lateral margins of the somites (white arrow). E: Sema3F expression is detected in the notochord, but also in the spinal cord, the hypochord, the posterior endoderm, and the branchial arches. F: Sema4C notochord expression is replaced by expression in the posterior cardinal vein, the heart, and the branchial arches. G: Sema4D expression is detected in the notochord. H: Sema5B expression in the notochord is replaced by spinal cord, pronephros, brain, and eye expression. ba, branchial arches; cg, cement gland; en, endoderm; g, gut; h, heart; hc, hypochord; no, notochord; op, otic placode; p, pronephros; pcv, posterior cardinal vein; pd, proctodeum; s, somites; sc, spinal cord; sm, splanchnic mesoderm.

Image published in: Koestner U et al. (2008)

Copyright © 2008. Image reproduced with permission of the Publisher, John Wiley & Sons.

GeneSynonymsSpeciesStage(s)Tissue
sema4d.LLOC108714852, LOC108707000X.laevisThroughout NF stage 31notochord
sema4c.LX.laevisThroughout NF stage 31heart
posterior cardinal vein
branchial arch
spinal cord
head region
roof plate
sema4b.SX.laevisThroughout NF stage 26cement gland
pronephric kidney
otic placode
proctodeum
intersomitic region
sema3fl.Lsema4, semak, sema-ivX.laevisThroughout NF stage 25notochord
branchial arch
spinal cord
hypochord
floor plate
rhombomere
sema5b.Ssemg, semag, semaphorin-5BX.laevisThroughout NF stage 37 and 38spinal cord
pronephric kidney
head region
branchial arch
sema3a.LSema 3AX.laevisThroughout NF stage 26somite
splanchnic layer of lateral plate mesoderm
head region
presomitic mesoderm
sema6b.LX.laevisThroughout NF stage 22somite
otic placode
sema6b.LX.laevisThroughout NF stage 35 and 36intersomitic region
eye
hypaxial muscle
hindbrain
forebrain
spinal cord

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