XB-PHENO-25420

Flach H et al. (2021)

Xla Wt + rbp1 MO1

NF42

Anatomical Phenotype
abnormal retinal layer abnormal retinal layer morphology abnormal retinal pigmented epithelium morphology

Expression Phenotype
decreased amount vsx1.L expression in retina decreased amount pax6.L expression in retina decreased amount pou1f1.L expression in retina decreased amount prox1.L expression in retina decreased amount rho.L expression in retina

fig.S2.a

Rothe M et al. (2017)

Xla Wt + epha4 MO

NF42 (in situ hybridization)

Anatomical Phenotype
abnormal development of retinal layer abnormally localised retinal inner nuclear layer

Expression Phenotype

increased amount vsx1.L expression in retinal inner nuclear layer
decreased amount rho.L expression in photoreceptor layer
increased amount pax6.L expression in amacrine cell
increased amount pax6.L expression in retinal ganglion cell layer
increased amount pou4f1.L expression in retinal ganglion cell layer
mislocalised pax6.L expression in retinal inner nuclear layer
mislocalised rho.L expression in retinal inner nuclear layer

fig.S2.b

Rothe M et al. (2017)

Xla Wt + epha4 MO

NF42 (RT-PCR)

Expression Phenotype
increased amount vsx1.L expression in eye decreased amount rho.L expression in eye increased amount pax6.L expression in eye increased amount pou4f1.L expression in eye

fig.S2.a

Rothe M et al. (2017)

Xla Wt + sipa1l3 MO

NF42 (in situ hybridization)

Anatomical Phenotype
abnormal development of eye abnormal development of retinal layer abnormal retinal ganglion cell layer morphology abnormally localised retinal ganglion cell layer abnormally localised retinal inner nuclear layer

Expression Phenotype

increased amount vsx1.L expression in retinal inner nuclear layer
mislocalised vsx1.L expression in retinal ganglion cell layer
decreased amount rho.L expression in photoreceptor layer
increased amount pax6.L expression in amacrine cell
increased amount pax6.L expression in retinal ganglion cell layer
increased amount pou4f1.L expression in retinal ganglion cell layer
mislocalised pax6.L expression in photoreceptor layer
mislocalised pax6.L expression in retinal inner nuclear layer
mislocalised rho.L expression in retinal inner nuclear layer

fig.S2.b

Rothe M et al. (2017)

Xla Wt + sipa1l3 MO

NF42 (RT-PCR)

Expression Phenotype
increased amount vsx1.L expression in eye decreased amount rho.L expression in eye increased amount pax6.L expression in eye increased amount pou4f1.L expression in eye