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XB-PHENO-16549

Xtr WT + dyrk1a MO, Willsey HR et al. (2020)

Experiment + Assay: Xtr WT + dyrk1a MO + NF35/36 (immunohistochemistry)
Background: Xtr.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
morpholino injection dyrk1a MO1 dyrk1a
 NF stage 2 (2-cell) blastomere
Conditions:
Assay Type Assay Stages Antibody
immunohistochemistry NF stage 35 and 36 to NF stage 35 and 36 Tuba4b Ab5
Anatomical Phenotypes: abnormal multiciliated cell , abnormally decreased number of cilium in the ciliated cell
Expression Phenotypes (1):
absent dyrk1a expression in multiciliated cell
Source: Fig S1 B-B"
Article: XB-ART-57038, PubMed