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XB-PHENO-24626

Xla Wt + kmt2d MO, Schwenty-Lara J et al. (2019)

Experiment + Assay: Xla Wt + kmt2d MO + NF29/30 (in situ hybridization)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
morpholino injection kmt2d MO1 kmt2d (Xla)
 NF stage 3 (4-cell) blastomere
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 29 and 30 to NF stage 29 and 30  
Anatomical Phenotypes: abnormal development of secondary heart field
Expression Phenotypes (1):
decreased amount isl1.L expression in secondary heart field
Human Disease Associations: congenital heart disease, Kabuki syndrome
Source: Fig. 6 J K L
Article: XB-ART-55860, PubMed