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XB-PHENO-24628

Xla Wt + kmt2d MO, Schwenty-Lara J et al. (2019)

Experiment + Assay: Xla Wt + kmt2d MO + NF28 (in situ hybridization)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
morpholino injection kmt2d MO2 kmt2d (Xla)
 NF stage 3 (4-cell) blastomere
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 28 to NF stage 28  
Anatomical Phenotypes: abnormal development of heart primordium
Expression Phenotypes (1):
decreased amount nkx2-5.L expression in heart primordium
Human Disease Associations: congenital heart disease, Kabuki syndrome
Source: Fig. 7 E G
Article: XB-ART-55860, PubMed