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Profile Publications(50)

Publications By Martin F Flajnik

Results 1 - 50 of 50 results

Page(s): 1

Inferring the "Primordial Immune Complex": Origins of MHC Class I and Antigen Receptors Revealed by Comparative Genomics., Ohta Y, Kasahara M, O'Connor TD, Flajnik MF., J Immunol. January 1, 2019; 203 (7): 1882-1896.

"Double-duty" conventional dendritic cells in the amphibian Xenopus as the prototype for antigen presentation to B cells., Neely HR, Guo J, Flowers EM, Criscitiello MF, Flajnik MF., Eur J Immunol. January 1, 2018; 48 (3): 430-440.

Genome evolution in the allotetraploid frog Xenopus laevis., Session AM, Uno Y, Kwon T, Chapman JA, Toyoda A, Takahashi S, Fukui A, Hikosaka A, Suzuki A, Kondo M, van Heeringen SJ, Quigley I, Heinz S, Ogino H, Ochi H, Hellsten U, Lyons JB, Simakov O, Putnam N, Stites J, Kuroki Y, Tanaka T, Michiue T, Watanabe M, Bogdanovic O, Lister R, Georgiou G, Paranjpe SS, van Kruijsbergen I, Shu S, Carlson J, Kinoshita T, Ohta Y, Mawaribuchi S, Jenkins J, Grimwood J, Schmutz J, Mitros T, Mozaffari SV, Suzuki Y, Haramoto Y, Yamamoto TS, Takagi C, Heald R, Miller K, Haudenschild C, Kitzman J, Nakayama T, Izutsu Y, Robert J, Fortriede J, Burns K, Lotay V, Karimi K, Yasuoka Y, Dichmann DS, Flajnik MF, Houston DW, Shendure J, DuPasquier L, Vize PD, Zorn AM, Ito M, Marcotte EM, Wallingford JB, Ito Y, Asashima M, Ueno N, Matsuda Y, Veenstra GJ, Fujiyama A, Harland RM, Taira M, Rokhsar DS., Nature. January 1, 2016; 538 (7625): 336-343.                              

Coevolution of MHC genes (LMP/TAP/class Ia, NKT-class Ib, NKp30-B7H6): lessons from cold-blooded vertebrates., Ohta Y, Flajnik MF., Immunol Rev. September 1, 2015; 267 (1): 6-15.

Evolution of the B7 family: co-evolution of B7H6 and NKp30, identification of a new B7 family member, B7H7, and of B7''s historical relationship with the MHC., Flajnik MF, Tlapakova T, Criscitiello MF, Krylov V, Ohta Y., Immunogenetics. August 1, 2012; 64 (8): 571-90.

The dynamic TCRδ: TCRδ chains in the amphibian Xenopus tropicalis utilize antibody-like V genes., Parra ZE, Ohta Y, Criscitiello MF, Flajnik MF, Miller RD., Eur J Immunol. August 1, 2010; 40 (8): 2319-29.

Evolutionarily conserved and divergent regions of the autoimmune regulator (Aire) gene: a comparative analysis., Saltis M, Criscitiello MF, Ohta Y, Keefe M, Trede NS, Goitsuka R, Flajnik MF., Immunogenetics. February 1, 2008; 60 (2): 105-14.

Localization and differential expression of activation-induced cytidine deaminase in the amphibian Xenopus upon antigen stimulation and during early development., Marr S, Morales H, Bottaro A, Cooper M, Flajnik M, Robert J., J Immunol. November 15, 2007; 179 (10): 6783-9.

Four primordial immunoglobulin light chain isotypes, including lambda and kappa, identified in the most primitive living jawed vertebrates., Criscitiello MF, Flajnik MF., Eur J Immunol. October 1, 2007; 37 (10): 2683-94.

IgD, like IgM, is a primordial immunoglobulin class perpetuated in most jawed vertebrates., Ohta Y, Flajnik M., Proc Natl Acad Sci U S A. July 11, 2006; 103 (28): 10723-8.

Ancestral organization of the MHC revealed in the amphibian Xenopus., Ohta Y, Goetz W, Hossain MZ, Nonaka M, Flajnik MF., J Immunol. March 15, 2006; 176 (6): 3674-85.

Cloning and characterization of Xenopus beta2-microglobulin., Stewart R, Ohta Y, Minter RR, Gibbons T, Horton TL, Ritchie P, Horton JD, Flajnik MF, Watson MD., Dev Comp Immunol. January 1, 2005; 29 (8): 723-32.

Two highly divergent ancient allelic lineages of the transporter associated with antigen processing (TAP) gene in Xenopus: further evidence for co-evolution among MHC class I region genes., Ohta Y, Powis SJ, Lohr RL, Nonaka M, Pasquier LD, Flajnik MF., Eur J Immunol. November 1, 2003; 33 (11): 3017-27.

Xenopus class II A genes: studies of genetics, polymorphism, and expression., Liu Y, Kasahara M, Rumfelt LL, Flajnik MF., Dev Comp Immunol. October 1, 2002; 26 (8): 735-50.

Trans-species polymorphism of the major histocompatibility complex-encoded proteasome subunit LMP7 in an amphibian genus, Xenopus., Nonaka M, Yamada-Namikawa C, Flajnik MF, Du Pasquier L., Immunogenetics. March 1, 2000; 51 (3): 186-92.

Early and natural antibodies in non-mammalian vertebrates., Flajnik MF, Rumfelt LL., Curr Top Microbiol Immunol. January 1, 2000; 252 233-40.

Two ancient allelic lineages at the single classical class I locus in the Xenopus MHC., Flajnik MF, Ohta Y, Greenberg AS, Salter-Cid L, Carrizosa A, Du Pasquier L, Kasahara M., J Immunol. October 1, 1999; 163 (7): 3826-33.

Identification and genetic mapping of Xenopus TAP2 genes., Ohta Y, Powis SJ, Coadwell WJ, Haliniewski DE, Liu Y, Li H, Flajnik MF., Immunogenetics. March 1, 1999; 49 (3): 171-82.  

Insight into the primordial MHC from studies in ectothermic vertebrates., Flajnik MF, Ohta Y, Namikawa-Yamada C, Nonaka M., Immunol Rev. February 1, 1999; 167 59-67.

Somatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: possible role in antigen-driven reactions in the absence of germinal centers., Diaz M, Greenberg AS, Flajnik MF., Proc Natl Acad Sci U S A. November 24, 1998; 95 (24): 14343-8.

Expression of MHC class Ia and class Ib during ontogeny: high expression in epithelia and coregulation of class Ia and lmp7 genes., Salter-Cid L, Nonaka M, Flajnik MF., J Immunol. March 15, 1998; 160 (6): 2853-61.

Evolution of proteasome subunits delta and LMP2: complementary DNA cloning and linkage analysis with MHC in lower vertebrates., Nonaka M, Namikawa-Yamada C, Sasaki M, Salter-Cid L, Flajnik MF., J Immunol. July 15, 1997; 159 (2): 734-40.

Major histocompatibility complex gene mapping in the amphibian Xenopus implies a primordial organization., Nonaka M, Namikawa C, Kato Y, Sasaki M, Salter-Cid L, Flajnik MF., Proc Natl Acad Sci U S A. May 27, 1997; 94 (11): 5789-91.

Involvement of thyroid hormones in the expression of MHC class I antigens during ontogeny in Xenopus., Rollins-Smith LA, Flajnik MF, Blair PJ, Davis AT, Green WF., Dev Immunol. January 1, 1997; 5 (2): 133-44.

The immune system of ectothermic vertebrates., Flajnik MF., Vet Immunol Immunopathol. November 1, 1996; 54 (1-4): 145-50.

Isolation and characterization of a cDNA encoding a Xenopus 70-kDa heat shock cognate protein, Hsc70.I., Ali A, Salter-Cid L, Flajnik MF, Heikkila JJ., Comp Biochem Physiol B Biochem Mol Biol. April 1, 1996; 113 (4): 681-7.

Isolation of Xenopus LMP-7 homologues. Striking allelic diversity and linkage to MHC., Namikawa C, Salter-Cid L, Flajnik MF, Kato Y, Nonaka M, Sasaki M., J Immunol. August 15, 1995; 155 (4): 1964-71.

Duplication of the MHC-linked Xenopus complement factor B gene., Kato Y, Salter-Cid L, Flajnik MF, Namikawa C, Sasaki M, Nonaka M., Immunogenetics. January 1, 1995; 42 (3): 196-203.

Exon-intron organization of Xenopus MHC class II beta chain genes., Kobari F, Sato K, Shum BP, Tochinai S, Katagiri M, Ishibashi T, Du Pasquier L, Flajnik MF, Kasahara M., Immunogenetics. January 1, 1995; 42 (5): 376-85.

Isolation of the Xenopus complement factor B complementary DNA and linkage of the gene to the frog MHC., Kato Y, Salter-Cid L, Flajnik MF, Kasahara M, Namikawa C, Sasaki M, Nonaka M., J Immunol. November 15, 1994; 153 (10): 4546-54.

Hsp70 genes are linked to the Xenopus major histocompatibility complex., Salter-Cid L, Kasahara M, Flajnik MF., Immunogenetics. January 1, 1994; 39 (1): 1-7.

Isolation of a classical MHC class I cDNA from an amphibian. Evidence for only one class I locus in the Xenopus MHC., Shum BP, Avila D, Du Pasquier L, Kasahara M, Flajnik MF., J Immunol. November 15, 1993; 151 (10): 5376-86.

A novel type of class I gene organization in vertebrates: a large family of non-MHC-linked class I genes is expressed at the RNA level in the amphibian Xenopus., Flajnik MF, Kasahara M, Shum BP, Salter-Cid L, Taylor E, Du Pasquier L., EMBO J. November 1, 1993; 12 (11): 4385-96.

MHC restriction of T-cell proliferative responses in Xenopus., Harding FA, Flajnik MF, Cohen N., Dev Comp Immunol. September 1, 1993; 17 (5): 425-37.

Evolution of the MHC: isolation of class II beta-chain cDNA clones from the amphibian Xenopus laevis., Sato K, Flajnik MF, Du Pasquier L, Katagiri M, Kasahara M., J Immunol. April 1, 1993; 150 (7): 2831-43.

Evolution of the major histocompatibility complex: molecular cloning of major histocompatibility complex class I from the amphibian Xenopus., Flajnik MF, Canel C, Kramer J, Kasahara M., Proc Natl Acad Sci U S A. January 15, 1991; 88 (2): 537-41.

Evolution of the MHC: antigenicity and unusual tissue distribution of Xenopus (frog) class II molecules., Flajnik MF, Ferrone S, Cohen N, Du Pasquier L., Mol Immunol. May 1, 1990; 27 (5): 451-62.

Expression of MHC class II antigens during Xenopus development., Du Pasquier L, Flajnik MF., Dev Immunol. January 1, 1990; 1 (2): 85-95.

Experimental analysis of ventral blood island hematopoiesis in Xenopus embryonic chimeras., Smith PB, Flajnik MF, Turpen JB., Dev Biol. February 1, 1989; 131 (2): 302-12.

The immune system of Xenopus., Du Pasquier L, Schwager J, Flajnik MF., Annu Rev Immunol. January 1, 1989; 7 251-75.

MHC class I antigens as surface markers of adult erythrocytes during the metamorphosis of Xenopus., Flajnik MF, Du Pasquier L., Dev Biol. July 1, 1988; 128 (1): 198-206.

Changes in the immune system during metamorphosis of Xenopus., Flajnik MF, Hsu E, Kaufman JF, Pasquier LD., Immunol Today. January 1, 1987; 8 (2): 58-64.

Major histocompatibility complex-encoded class I molecules are absent in immunologically competent Xenopus before metamorphosis., Flajnik MF, Kaufman JF, Hsu E, Manes M, Parisot R, Du Pasquier L., J Immunol. December 15, 1986; 137 (12): 3891-9.  

A third immunoglobulin class in amphibians., Hsu E, Flajnik MF, Du Pasquier L., J Immunol. September 1, 1985; 135 (3): 1998-2004.

Immune responses of thymus/lymphocyte embryonic chimeras: studies on tolerance and major histocompatibility complex restriction in Xenopus., Flajnik MF, Du Pasquier L, Cohen N., Eur J Immunol. June 1, 1985; 15 (6): 540-7.

Xenopus MHC class II molecules. II. Polymorphism as determined by two-dimensional gel electrophoresis., Kaufman JF, Flajnik MF, Du Pasquier L., J Immunol. May 1, 1985; 134 (5): 3258-64.

Xenopus MHC class II molecules. I. Identification and structural characterization., Kaufman JF, Flajnik MF, Du Pasquier L, Riegert P., J Immunol. May 1, 1985; 134 (5): 3248-57.

Studies on the Xenopus major histocompatibility complex., Flajnik MF, Kaufman JF, Du Pasquier L., Dev Comp Immunol. January 1, 1985; 9 (4): 777-81.

A flow cytometric analysis of the embryonic origin of lymphocytes in diploid/triploid chimeric Xenopus laevis., Flajnik MF, Horan PK, Cohen N., Dev Biol. July 1, 1984; 104 (1): 247-54.

Identification of class I major histocompatibility complex encoded molecules in the amphibian Xenopus., Flajnik MF, Kaufman JF, Riegert P, Du Pasquier L., Immunogenetics. January 1, 1984; 20 (4): 433-42.

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