My laboratory’s primary interest is in determining the role of egg histone variants, histone chaperones, and histone post-translational modifications in establishing an embryonic epigenetic state. Histones are the primary protein constituent of chromatin, the physiological form of the eukaryotic genome. Chromatin is the actual substrate for all information-transactions that occur in the nucleus. Information encoded in the proteins of chromatin can be considered “epigenetic information” and is important for an overall increase in the complexity of the genome without changes in underlying gene sequence. Epigenetics has clinical significance that has become more apparent, and is explicitly connected with the process of pattern formation crucial for proper development of metazoans. Stem cells and eggs have garnered much recent attention for their ability to develop into any tissue and from the desire to see novel medical interventions using patient-derived tissues to restore normal function to diseased tissue.
Lab MembershipsShechter Lab (Principal Investigator/Director)
Department of Biochemistry
Albert Einstein College of Medicine
1300 Morris Park Ave