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Regenerative medicine: Amphibian limb models to resolve why humans lost their ability to regenerate organs
Evolution is thought to have led to the loss of organ-regeneration potency in humans. However some lower vertebrates, such as newts and axolotls, have still retained their organ regeneration potency. Thus understanding of why lower vertebrates are able to regenerate organs would be useful to improve our poor ability of organ regeneration.
Limb regeneration has been studied as a model representing organ regeneration for more than a 100 years. Recently, a new experimental system referred to as the accessory limb model, has led to a major breakthrough in research on limb regeneration. The model clearly shows that nerves trigger the regeneration of limbs, where the presence of nerves governs early regulation of limb regeneration. Thus, research is focused on nerve regulation