The molecular mechanisms underlying the β-catenin nuclear localization, Wnt signalling,
Various signaling molecules inducing the cell-growth and differentiation regulate morphogenesis and organogenesis of the vertebrate. The failure of these signal molecules has also been caused with induction of the diseases. Therefore, the elucidation of signal transduction network regulating generation and differentiation is important upon clarifying the mechanism of morphogenesis, organogenesis and diseases. We focus on the signal transduction network regulating the mechanisms of morphogenesis and organogenesis in developmental process.
1. Regulatory mechanisms of Wnt signaling pathways
2. Regulatory mechanisms of WNK signaling pathways