My research focuses on the epithelial cells of the gastrointestine which undergo a rapid cell-renewal and originate from stem cells throughout the life of the organisms. The microenvironment around the stem cells called “niche” is thought to play important roles in this control, and its disruption leads to diseases or disorders such as cancer
in the human gastrointestine. Although understanding how the niche affects the stem cells is clinically important, its mechanisms still remain mostly unknown at the molecular level. We use Xenopus laevis intestine as a model as it is applicable to regenerative medicine.