Dr. Caroline S Hill
PositionResearch Scientist & Group Leader
The work of my laboratory focuses on the Transforming Growth Factor Beta (TGF-Beta) superfamily, a group of growth and differentiation factors comprising the TGF-Betas, Activins, Nodals, BMPs and GDFs. These ligands play critical roles during early vertebrate development in the specification and subsequent patterning of the germ layers, and deregulation of TGF-Beta, BMP and Nodal signalling has been implicated in cancer. We want to understand the mechanism whereby these ligands signal from the plasma membrane to the nucleus and how they regulate transcription of target genes via activated complexes of Smad proteins. We want to determine how they function and are regulated in embryonic development, and how their activity is perturbed in cancer.
Lab MembershipsThe Hill Lab (Principal Investigator/Director)
British Xenopus Group (Other)
+44 (0) 20 7269 2941
Fax: +44 (0) 20 7269 3093