The gene plk1 in Strongylocentrotus purpuratus encodes a serine/threonine kinase that functions as a key regulator of cell cycle progression, particularly in mitosis. This kinase is involved in regulat...[+]

The gene plk1 in Strongylocentrotus purpuratus encodes a serine/threonine kinase that functions as a key regulator of cell cycle progression, particularly in mitosis. This kinase is involved in regulating mitotic events, including spindle assembly and chromosome segregation. It is expressed in dividing cells during embryonic development, particularly in blastomeres during early development. The plk1 protein localizes to the centrosomes and spindle apparatus during cell division, where it regulates mitotic progression. Its function is crucial for proper chromosome segregation and cell division in sea urchin embryos. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD