Xenbase Image ID: 41228

Fig. 1. Slit1 and slit2 are expressed in the developing Xenopus retina. (Aâ F) Transverse vibratome sections through the retinas of Xenopus embryos processed for wholemount in situ hybridization against slit1 (A, C, E) or slit2 (B, D, F). slit1 mRNA is expressed in the floor plate of the neural tube at stages 30â 35/36 (A, C). Weak mRNA expression is evident in the ganglion cell layer (GCL, as marked by **, A and E) by stage 30, and maintained at stages 33/34 (E) and 35/36 (C). Slit2 mRNA is expressed in the inner nuclear layer (INL) of the developing Xenopus retina (B, D, F).Slit2 is expressed in the floor plate and roof plate at stages 35/36 and 37/38 (B, D). At stage 35/36, expression in the retina is observed in the proliferative ciliary marginal zone (CMZ; arrowheads), and in central retinal cells of the INL (B). CMZ expression is lost by stage 37/38, while INL expression spreads across the whole layer (D). A higher magnification image of a stage 37/38 retina (F) highlights the location of the slit2 expression in the inner portion of the INL (INL is delineated by the black bars) and not in the GCL (**). Scale bars are 50â î¼m in A for Aâ D and in E for Eâ F. br, brain; D, dorsal; fp, floor plate; INL, inner nuclear layer; L, lens; nr, neural retina; rp, roof plate; V, ventral. Image published in: Hocking JC et al. (2010) Copyright © 2010. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue slit2.S LOC108698051, slil3, slit-2 X. laevis Throughout NF stage 35 and 36 retinal inner nuclear layer ciliary marginal zone spinal cord floor plate slit1.S LOC108695757, megf4, slil1, slit-1, Xslit X. laevis Throughout NF stage 29 and 30 floor plate retinal ganglion cell layer neural tube spinal cord slit2.S LOC108698051, slil3, slit-2 X. laevis Sometime during NF stage 35 and 36 to NF stage 37 and 38 floor plate roof plate retinal inner nuclear layer slit1.S LOC108695757, megf4, slil1, slit-1, Xslit X. laevis Throughout NF stage 33 and 34   slit1.S LOC108695757, megf4, slil1, slit-1, Xslit X. laevis Throughout NF stage 35 and 36 spinal cord floor plate retinal ganglion cell layer Image source: Published Larger Image Printer Friendly View

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