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Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer. , Levin M ., Cell. April 15, 2021;
Toward a Structural View of hERG Activation by the Small-Molecule Activator ICA-105574. , Zangerl-Plessl EM., J Chem Inf Model. January 27, 2020; 60 (1): 360-371.
Design and Synthesis of Novel Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors with the Ability To Rescue Auditory Gating Deficit in Mice. , Li Y., J Med Chem. January 10, 2019; 62 (1): 159-173.
Molecular Basis of Altered hERG1 Channel Gating Induced by Ginsenoside Rg3. , Gardner A., Mol Pharmacol. October 1, 2017; 92 (4): 437-450.
Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4. , Abbott GW., Sci Rep. December 6, 2016; 6 38412.
Molecular Cloning and Functional Expression of the Equine K+ Channel KV11.1 (Ether à Go-Go-Related/KCNH2 Gene) and the Regulatory Subunit KCNE2 from Equine Myocardium. , Pedersen PJ., PLoS One. September 4, 2015; 10 (9): e0138320.
Blocking of the human ether-à- go-go-related gene channel by imatinib mesylate. , Dong Q., Biol Pharm Bull. January 1, 2013; 36 (2): 268-75.
Kcnh1 voltage-gated potassium channels are essential for early zebrafish development. , Stengel R., J Biol Chem. October 12, 2012; 287 (42): 35565-35575.
Sig1R protein regulates hERG channel expression through a post-translational mechanism in leukemic cells. , Crottès D., J Biol Chem. August 12, 2011; 286 (32): 27947-58.
Recombinant expression of the toxic peptide ErgTx1 and role of Met35 on its stability and function. , Jimenez-Vargas JM., Peptides. March 1, 2011; 32 (3): 560-7.
Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels. , Larsen AP., Br J Pharmacol. October 1, 2010; 161 (3): 614-28.
Response of i(kr) and HERG currents to the antipsychotics tiapride and sulpiride. , Jo SH., Korean J Physiol Pharmacol. October 1, 2010; 14 (5): 305-10.
Modification of hERG1 channel gating by Cd2+. , Abbruzzese J., J Gen Physiol. August 1, 2010; 136 (2): 203-24.
Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine. , Obers S., Naunyn Schmiedebergs Arch Pharmacol. May 1, 2010; 381 (5): 385-400.
Inhibition of the human ether-a- go-go-related gene ( HERG) K+ channels by Lindera erythrocarpa. , Hong HK., J Korean Med Sci. December 1, 2009; 24 (6): 1089-98.
H(1) antihistamine drug promethazine directly blocks hERG K(+) channel. , Jo SH., Pharmacol Res. November 1, 2009; 60 (5): 429-37.
Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/ NR2B N-methyl-D-aspartate receptors. , Mosley CA., Bioorg Med Chem. September 1, 2009; 17 (17): 6463-80.
Characterization of novel KCNH2 mutations in type 2 long QT syndrome manifesting as seizures. , Keller DI., Can J Cardiol. August 1, 2009; 25 (8): 455-62.
Differential modulation of cardiac potassium channels by Grb adaptor proteins. , Ureche ON., Biochem Biophys Res Commun. June 19, 2009; 384 (1): 28-31.
Discovery of a novel activator of KCNQ1- KCNE1 K channel complexes. , Mruk K., PLoS One. January 1, 2009; 4 (1): e4236.
Selective noradrenaline reuptake inhibitor atomoxetine directly blocks hERG currents. , Scherer D., Br J Pharmacol. January 1, 2009; 156 (2): 226-36.
The effects of chiral isolates of methadone on the cardiac potassium channel IKr. , Lin C., Cardiology. January 1, 2009; 113 (1): 59-65.
Extracellular potassium dependency of block of HERG by quinidine and cisapride is primarily determined by the permeant ion and not by inactivation. , Barrows B., Channels (Austin). January 1, 2009; 3 (4): 239-48.
Papaverine, a vasodilator, blocks the pore of the HERG channel at submicromolar concentration. , Kim YJ., J Cardiovasc Pharmacol. December 1, 2008; 52 (6): 485-93.
[Analysis and analyzing mechanisms of HERG channel kinetics]. , Wang X ., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. October 1, 2008; 25 (5): 1068-73.
Clomipramine block of the hERG K+ channel: accessibility to F656 and Y652. , Jo SH., Eur J Pharmacol. September 11, 2008; 592 (1-3): 19-25.
Characterization of hERG1a and hERG1b potassium channels-a possible role for hERG1b in the I (Kr) current. , Larsen AP., Pflugers Arch. September 1, 2008; 456 (6): 1137-48.
Electropharmacological properties of telmisartan in blocking hKv1.5 and HERG potassium channels expressed on Xenopus laevis oocytes. , Tu DN., Acta Pharmacol Sin. August 1, 2008; 29 (8): 913-22.
Inhibition of cardiac hERG potassium channels by tetracyclic antidepressant mianserin. , Scherer D., Naunyn Schmiedebergs Arch Pharmacol. July 1, 2008; 378 (1): 73-83.
Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels. , Cuypers E., Toxicon. May 1, 2008; 51 (6): 974-83.
Upregulation of KCNE1 induces QT interval prolongation in patients with chronic heart failure. , Watanabe E., Circ J. April 1, 2007; 71 (4): 471-8.
Mutational analysis of block and facilitation of HERG current by a class III anti-arrhythmic agent, nifekalant. , Hosaka Y., Channels (Austin). January 1, 2007; 1 (3): 198-208.
Blockade of HERG human K+ channel and IKr of guinea pig cardiomyocytes by prochlorperazine. , Kim MD ., Eur J Pharmacol. August 21, 2006; 544 (1-3): 82-90.
In vitro modulation of HERG channels by organochlorine solvent trichlormethane as potential explanation for proarrhythmic effects of chloroform. , Scholz EP., Toxicol Lett. August 20, 2006; 165 (2): 156-66.
Atypical tetracyclic antidepressant maprotiline is an antagonist at cardiac hERG potassium channels. , Kiesecker C., Naunyn Schmiedebergs Arch Pharmacol. June 1, 2006; 373 (3): 212-20.
Effect of S5P alpha-helix charge mutants on inactivation of hERG K+ channels. , Clarke CE., J Physiol. June 1, 2006; 573 (Pt 2): 291-304.
Molecular determinants of HERG channel block. , Kamiya K., Mol Pharmacol. May 1, 2006; 69 (5): 1709-16.
Chemical modification of the human ether-a- go-go-related gene ( HERG) K+ current by the amino-group reagent trinitrobenzene sulfonic acid. , Jo SH., Arch Pharm Res. April 1, 2006; 29 (4): 310-7.
Inhibition of cardiac HERG potassium channels by antidepressant maprotiline. , Ferrer-Villada T., Eur J Pharmacol. February 15, 2006; 531 (1-3): 1-8.
Drug binding interactions in the inner cavity of HERG channels: molecular insights from structure-activity relationships of clofilium and ibutilide analogs. , Perry M ., Mol Pharmacol. February 1, 2006; 69 (2): 509-19.
Mechanism of action of a novel human ether-a- go-go-related gene channel activator. , Casis O., Mol Pharmacol. February 1, 2006; 69 (2): 658-65.
Block of HERG channels by berberine: mechanisms of voltage- and state-dependence probed with site-directed mutant channels. , Rodriguez-Menchaca A., J Cardiovasc Pharmacol. January 1, 2006; 47 (1): 21-9.
The effects of sevoflurane and propofol on QT interval and heterologously expressed human ether-a- go-go related gene currents in Xenopus oocytes. , Yamada M., Anesth Analg. January 1, 2006; 102 (1): 98-103.
Inhibitory effect of rhynchophylline on human ether-a- go-go related gene channel. , Gui L., Sheng Li Xue Bao. October 25, 2005; 57 (5): 648-52.
Interactions between charged residues in the transmembrane segments of the voltage-sensing domain in the hERG channel. , Zhang M., J Membr Biol. October 1, 2005; 207 (3): 169-81.
Molecular mapping of a site for Cd2+-induced modification of human ether-à- go-go-related gene ( hERG) channel activation. , Fernandez D., J Physiol. September 15, 2005; 567 (Pt 3): 737-55.
Inhibition of human ether-a- go-go-related gene K+ channel and IKr of guinea pig cardiomyocytes by antipsychotic drug trifluoperazine. , Choi SY., J Pharmacol Exp Ther. May 1, 2005; 313 (2): 888-95.
The influence of extracellular acidosis on the effect of IKr blockers. , Lin C., J Cardiovasc Pharmacol Ther. March 1, 2005; 10 (1): 67-76.
A mechanism for the potential proarrhythmic effect of acidosis, bradycardia, and hypokalemia on the blockade of human ether-a- go-go-related gene ( HERG) channels. , Lin C., Am J Ther. January 1, 2005; 12 (4): 328-36.
Class Ia anti-arrhythmic drug ajmaline blocks HERG potassium channels: mode of action. , Kiesecker C., Naunyn Schmiedebergs Arch Pharmacol. December 1, 2004; 370 (6): 423-35.