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Polyunsaturated fatty acid analogues differentially affect cardiac NaV, CaV, and KV channels through unique mechanisms. , Bohannon BM., Elife. March 24, 2020; 9
Non-sedating antihistamines block G-protein-gated inwardly rectifying K+ channels. , Chen IS., Br J Pharmacol. September 1, 2019; 176 (17): 3161-3179.
Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo. , Baburin I., Pharmacol Res. May 1, 2018; 131 150-163.
Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4. , Abbott GW., Sci Rep. December 6, 2016; 6 38412.
Molecular Cloning and Functional Expression of the Equine K+ Channel KV11.1 (Ether à Go-Go-Related/KCNH2 Gene) and the Regulatory Subunit KCNE2 from Equine Myocardium. , Pedersen PJ., PLoS One. September 4, 2015; 10 (9): e0138320.
Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. , Liu QN., PLoS One. April 22, 2015; 10 (4): e0123951.
Concatenated hERG1 tetramers reveal stoichiometry of altered channel gating by RPR-260243. , Wu W., Mol Pharmacol. January 1, 2015; 87 (3): 401-9.
Concerted all-or-none subunit interactions mediate slow deactivation of human ether-à- go-go-related gene K+ channels. , Thomson SJ., J Biol Chem. August 22, 2014; 289 (34): 23428-36.
Up-regulation of Kir2.1 ( KCNJ2) by the serum & glucocorticoid inducible SGK3. , Munoz C., Cell Physiol Biochem. January 1, 2014; 33 (2): 491-500.
Effect of azelastine on cardiac repolarization of guinea-pig cardiomyocytes, hERG K⁺ channel, and human L-type and T-type Ca²⁺ channel. , Park MH., J Pharmacol Sci. September 20, 2013; 123 (1): 67-77.
Mechanisms of zolpidem-induced long QT syndrome: acute inhibition of recombinant hERG K(+) channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cells. , Jehle J., Br J Pharmacol. March 1, 2013; 168 (5): 1215-29.
Blocking of the human ether-à- go-go-related gene channel by imatinib mesylate. , Dong Q., Biol Pharm Bull. January 1, 2013; 36 (2): 268-75.
hERG K+ channel-associated cardiac effects of the antidepressant drug desipramine. , Staudacher I., Naunyn Schmiedebergs Arch Pharmacol. February 1, 2011; 383 (2): 119-39.
Response of i(kr) and HERG currents to the antipsychotics tiapride and sulpiride. , Jo SH., Korean J Physiol Pharmacol. October 1, 2010; 14 (5): 305-10.
Differential expression of hERG1 channel isoforms reproduces properties of native I(Kr) and modulates cardiac action potential characteristics. , Larsen AP., PLoS One. February 2, 2010; 5 (2): e9021.
Selective noradrenaline reuptake inhibitor atomoxetine directly blocks hERG currents. , Scherer D., Br J Pharmacol. January 1, 2009; 156 (2): 226-36.
Papaverine, a vasodilator, blocks the pore of the HERG channel at submicromolar concentration. , Kim YJ., J Cardiovasc Pharmacol. December 1, 2008; 52 (6): 485-93.
Characterization of hERG1a and hERG1b potassium channels-a possible role for hERG1b in the I (Kr) current. , Larsen AP., Pflugers Arch. September 1, 2008; 456 (6): 1137-48.
Extracellular acidification and hyperkalemia induce changes in HERG inhibition by ibutilide. , Lin C., Cardiology. January 1, 2008; 110 (3): 209-16.
Molecular interaction of droperidol with human ether-a- go-go-related gene channels: prolongation of action potential duration without inducing early afterdepolarization. , Schwoerer AP., Anesthesiology. May 1, 2007; 106 (5): 967-76.
The effect of high extracellular potassium on IKr inhibition by anti-arrhythmic agents. , Lin C., Cardiology. January 1, 2007; 108 (1): 18-27.
Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea]. , Hansen RS., Mol Pharmacol. October 1, 2006; 70 (4): 1319-29.
Blockade of HERG human K+ channel and IKr of guinea pig cardiomyocytes by prochlorperazine. , Kim MD ., Eur J Pharmacol. August 21, 2006; 544 (1-3): 82-90.
Blockade of HERG human K+ channels and IKr of guinea-pig cardiomyocytes by the antipsychotic drug clozapine. , Lee SY., Br J Pharmacol. June 1, 2006; 148 (4): 499-509.
Frequency-dependent modulation of KCNQ1 and HERG1 potassium channels. , Diness TG., Biochem Biophys Res Commun. May 19, 2006; 343 (4): 1224-33.
Activation of human ether-a- go-go-related gene potassium channels by the diphenylurea 1,3- bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643). , Hansen RS., Mol Pharmacol. January 1, 2006; 69 (1): 266-77.
In vivo targeting of ERG potassium channels in mice and dogs by a positron-emitting analogue of fluoroclofilium. , Kim SW., Exp Mol Med. August 31, 2005; 37 (4): 269-75.
Inhibition of human ether-a- go-go-related gene K+ channel and IKr of guinea pig cardiomyocytes by antipsychotic drug trifluoperazine. , Choi SY., J Pharmacol Exp Ther. May 1, 2005; 313 (2): 888-95.
Class Ia anti-arrhythmic drug ajmaline blocks HERG potassium channels: mode of action. , Kiesecker C., Naunyn Schmiedebergs Arch Pharmacol. December 1, 2004; 370 (6): 423-35.
Direct block of hERG potassium channels by the protein kinase C inhibitor bisindolylmaleimide I (GF109203X). , Thomas D., Cardiovasc Res. December 1, 2004; 64 (3): 467-76.
Activation properties of Kv4.3 channels: time, voltage and [K+]o dependence. , Wang S., J Physiol. June 15, 2004; 557 (Pt 3): 705-17.
Inhibition of human ether-a- go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin. , Thomas D., Naunyn Schmiedebergs Arch Pharmacol. May 1, 2004; 369 (5): 462-72.
Block of HERG human K(+) channel and IKr of guinea pig cardiomyocytes by chlorpromazine. , Lee SY., J Cardiovasc Pharmacol. May 1, 2004; 43 (5): 706-14.
Drug binding to aromatic residues in the HERG channel pore cavity as possible explanation for acquired Long QT syndrome by antiparkinsonian drug budipine. , Scholz EP., Naunyn Schmiedebergs Arch Pharmacol. November 1, 2003; 368 (5): 404-14.
Inhibitory effect of the class III antiarrhythmic drug nifekalant on HERG channels: mode of action. , Kushida S., Eur J Pharmacol. December 13, 2002; 457 (1): 19-27.
Interaction with GM130 during HERG ion channel trafficking. Disruption by type 2 congenital long QT syndrome mutations. Human Ether-à- go-go-Related Gene. , Roti EC., J Biol Chem. December 6, 2002; 277 (49): 47779-85.
[Evaluation of pro-arrhythmic risk of drugs due to QT interval prolongation by the HERG expression system]. , Chachin M., Nihon Yakurigaku Zasshi. June 1, 2002; 119 (6): 345-51.
Inhibition of cardiac potassium currents by pentobarbital. , Bachmann A., Naunyn Schmiedebergs Arch Pharmacol. January 1, 2002; 365 (1): 29-37.
Characterization of a novel Kv1.5 channel blocker in Xenopus oocytes, CHO cells, human and rat cardiomyocytes. , Bachmann A., Naunyn Schmiedebergs Arch Pharmacol. November 1, 2001; 364 (5): 472-8.
Molecular cloning and expression of cERG, the ether à go-go-related gene from canine myocardium. , Zehelein J., Pflugers Arch. May 1, 2001; 442 (2): 188-91.
High-affinity blockade of human ether-a- go-go-related gene human cardiac potassium channels by the novel antiarrhythmic drug BRL-32872. , Thomas D., J Pharmacol Exp Ther. May 1, 2001; 297 (2): 753-61.
Blocking effects of the antiarrhythmic drug propafenone on the HERG potassium channel. , Mergenthaler J., Naunyn Schmiedebergs Arch Pharmacol. April 1, 2001; 363 (4): 472-80.
Short- and long-term effects of amiodarone on the two components of cardiac delayed rectifier K(+) current. , Kamiya K., Circulation. March 6, 2001; 103 (9): 1317-24.
Inhibitory effects of berberine on IK1, IK, and HERG channels of cardiac myocytes. , Li BX., Acta Pharmacol Sin. February 1, 2001; 22 (2): 125-31.
Inhibition of IKs channels by HMR 1556. , Gögelein H., Naunyn Schmiedebergs Arch Pharmacol. December 1, 2000; 362 (6): 480-8.
KChAP as a chaperone for specific K(+) channels. , Kuryshev YA., Am J Physiol Cell Physiol. May 1, 2000; 278 (5): C931-41.
Norpropoxyphene-induced cardiotoxicity is associated with changes in ion-selectivity and gating of HERG currents. , Ulens C., Cardiovasc Res. December 1, 1999; 44 (3): 568-78.
Mechanism for the effects of extracellular acidification on HERG-channel function. , Jiang M., Am J Physiol. October 1, 1999; 277 (4): H1283-92.
Pathways of HERG inactivation. , Kiehn J., Am J Physiol. July 1, 1999; 277 (1): H199-210.
HERG potassium channel activation is shifted by phorbol esters via protein kinase A-dependent pathways. , Kiehn J., J Biol Chem. September 25, 1998; 273 (39): 25285-91.