Dr. Debora I Sinner
Debora Sinner, PhD, obtained her doctoral degree from University of Buenos Aires, Argentina. Her dissertation focused on the effects of maternal diabetes during murine embryonic development and role of prostaglandins and reactive species of oxygen in glucose induced abnormal development. As a postdoctoral trainee in the Division of Developmental Biology at Cincinnati Children's, Dr. Sinner focused on the molecular mechanisms underlying endoderm formation, the germ layer that gives rise to the gastrointestinal tract. Under the direction of her mentor, Aaron Zorn, PhD, we identified a mechanism by which Sox proteins regulate the Wnt signaling pathway during frog development. These findings are relevant since Wnt signaling pathway has been linked to development and disease. After completion of her doctoral training, Dr. Sinner accepted a faculty position in the Division of Neonatology and Pulmonary Biology at Cincinnati Children's within the UC Department of Pediatrics. Her current research focuses on upper airway and lung development. Dr. Sinner's lab is studying how paracrine Wnt signaling controls the differentiation of pulmonary cells lineages, including the microvasculature and airway cartilage.
Lab MembershipsZorn Lab (Post-doc, Alumni)