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18th International Xenopus Conference


The 18th International Xenopus Conference was held virtually August 15-19, 2021.

Content for registrants will be available until Friday, September 17, 2021.

Registrants click here to log in.

Official conference website.

Many thanks to the organizers, speakers, presenters, and participants!


Congratulations to Helen Willsey and Alice Godden named John Gurdon outstanding speaker award winners!


Conference Programme

Sunday, 15 August 2021

Session 1 - Chair: Christof Niehrs

PL01 - Aaron Zorn
The CLEAR consortium: discovering the developmental basis of trachea-esophageal birth defects

O01 - Clayton Gordy
One-Eared Frogs: Insights into Brainstem Sensorimotor Plasticity

O02 - Jennifer Landino
Changes in neighbor cell contractility alter the speed and success of epithelial cytokinesis

S01 - Jin-Kwan Han
Ripply2.2 induces VegT degradation in head organizer

S02 - Laurent Kodjabachian
Centriole synthesis in multiciliated cells

O03 - Seongmin Yun
Development of deep-learning-based high-throughput phenotype screening platform of Xenopus laevis embryos

O04 - Gerhard Schlosser
The role of Eya1 for otic neurogenesis in Xenopus laevis

Session 2 - Chair: Gerhard Schlosser

S03 - Roberto Mayor
Interplay between chemical and mechanical cues during neural crest migration

S04 - Stefan Hoppler
Wnt target genes in Xenopus development

S05 - Vaibhav Pai
Biophysical Control of Organogenesis: How Membrane Voltage Patterns Regulate Embryonic Neural Patterning and Regeneration

S06 - Robert Huebener
Mechanical heterogeneity along single cell-cell junctions is driven by lateral clustering of cadherins during vertebrate axis elongation


Session 3 - Chair: John Wallingford

S07 - Jerome Julien
Editing the sperm epigenome

S08 - Soeren Lienkamp
Models of kidney disease and ciliopathies

S09 - Rachel Miller
The Wnt/PCP formin, Daam1, drives cell-cell adhesion during nephron development

S10 - Lance Davidson
Mechanical discordance and jamming during neurulation. Or, What can we learn just by watching?

Sit down & chat - “All Sorts of People make Great Scientists; how do they do it?”

Monday, 16 August 2021

Live poster sessions + networking

Xenbase workshop 1 - GEO data
Explore RNA/ChIP-Seq data from GEO and Differentially Expressed Genes (DEG) on Xenbase

Session 1 - Chair: Steffan Hoppler

PL02: IXB - Young PI Andrea Wills
Decoding the metabolic requirements for regeneration

O05 - Hyo Jung Sim
Study on the functions of ERAD pathway in cartilage formation and osteoarthritis

O06 - Eva Pillai
Mechanical control of chemical signalling in the developing Xenopus brain

S11 - Naota Ueno
Force-dependent remodeling of a tight junction protein ZO-1 is regulated by phase-separation

S12 - Eva Hormandser

O07 - Karel Dorey
Identification of the molecular switch regulating the transition from proliferation to differentiation during spinal cord regeneration

O08 - Marcus Maerker
Bicc1 regulates left-right patterning through post-transcriptional control of the Nodal-inhibitor Dand5

Session 2 - Chair: Muriel Perron

S13 - Anne-H Monsoro-Burq
Spatio-temporal coordination of BMP and Wnt signaling by the scaffolding protein FHL3, a novel enhancer of BMP signaling, controls several steps of neural crest early development

S14 - Matt Good
Cell Size and Cell Cycle Dependent Mechanisms of Zygotic Genome Activation

S15- Carole LaBonne

S16- Coral Zhou
Mechanisms of mitotic chromosome scaling in Xenopus laevis

Session 3 - Chair: Marko Horb

S17 - Hazel Sive
The Extreme Anterior Domain: a Target for Microcephaly

S18 - Philipp Vick
Regulation of FGF signaling by the endosomal compartment - deep and superficial insights from the mesoderm

S19 - Orson Moritz
Modeling CRISPR-based gene therapies for retinitis pigmentosa in X. laevis

S20 - Leonid Peshkin
Xenopus proteomics Atlas

Poster session

Sit down & chat - career transitions

Xenbase workshop 1 - GEO data Repeat
Explore RNA/ChIP-Seq data from GEO and Differentially Expressed Genes (DEG) on Xenbase

Tuesday, 17 August 2021

Live poster sessions + networking

Xenbase Workshop 2 - Phenotypes
Explore Xenopus phenotypes effecting anatomy, biological processes, changes in gene expression and models of human disease

Session 1 - Chair: Roberto Mayor

PL03 - Jim Smith
From frogs to humans—just as we’d hoped

O09 - Ken Cho
Patterning the chromatin state along the germ layer axis in Xenopus

O10 - Marjolein Carron
Functional characterization of a Xenopus tropicalis knockout and a human cellular model of RCBTB1-associated inherited retinal disease shows involvement of RCBTB1 in the cellular response to oxidative stress

S21 - Makoto Nakamura
The AP-1 transcription factor JunB and TGF-β1 ligand are critical components of the early injury response leading to cell proliferation in Xenopus tadpole tail regeneration

S22 - Jenny Gallop
Intervening in membrane-triggered actin assembly

O11- Alexia Tasca
Multiciliated cells can undergo direct fate conversion through Notch signaling

O12 - Aparna Baxi
Time-resolved proteomic analysis of inner ear development in Xenopus laevis

Session 2 - Chair: Anne Monsoro-Burq

S23- Bill Bement
Further adventures in cortical excitability

S24 - Laura-Ann Lowery
Investigating the role of the CoREST repressor complex in melanoma metastasis in vivo

S25 - Lora Sweeney
Defining tetrapod motor circuit diversity across frog metamorphosis and vertebrate evolution

S26 - Enrique Amaya
Metabolic reprogramming during early embryonic development and appendage regeneration

Session 3 - Chair: Robert Grainger

S27 - Frank Conlon
The Evolution of the X-Chromosome and Cardiac Sex Disparities

S28 - Peter Walentek
Using Xenopus to understand mucociliary epithelial development, remodeling and diseases

S29 - Sally Moody
Human SIX1 mutations cause gene expression and morphological changes in craniofacial structures

S30 - Rudi Winklbauer
Cell adhesion in the Xenopus gastrula

Poster session

Sit down & chat - Xenopus Heath & Care

Xenbase Workshop 2 - Phenotypes repeat
Explore Xenopus phenotypes effecting anatomy, biological processes, changes in gene expression and models of human disease

Wednesday, 18 August 2021

Live poster sessions

13.00 - 16.00 Session 1: Chair: Gert Veenstra

PL04 - Karen Liu
Pathological missense variants in CTNND1 predict tissue specific protein functions

O13 - Thomas Naert
XenoVision: Deep learning for embryonic disease modeling

O14 - Alice Godden
Investigating the role of microRNAs in the development of Xenopus neual crest with CRISPR-Cas9

S31 - Yuuri Yasuoka
Comparing fluctuation of gene expression profiles in embryos to dissect diversification of Xenopus tropicalis strains

S32 - Gert Veenstra
From histone modifications to gene regulation

O15 - Podrowsky
Cell proliferation in Xenopus embryos antagonizes the accumulation of repressive histone marks by replicational dilution

O16 - Banerjee
A Xenopus laevis epilepsy model to test alternative therapy for Intractable Epilepsy

16.20 - 18.10 Session 2 - Chair: Sally Moody

S33 - Christof Niehrs
Novel mechanisms of R-spondins during early Xenopus development

S34 - Helen Willsey
Using frogs to identify convergent biology underlying complex genetic disorders including autism

S35 - Kristian Franze
The chemomechanical guidance of neuronal axons in the developing Xenopus brain

S36 - Mustafa Khokha
The nuclear transport of beta-catenin

Session 3 - Chair: Amy Sater

S37 - Muriel Perron
Xenopus retina regeneration: linking inflammation and stem cell reactivation

S38 - Peter Nemes
In vivo Subcellular Mass Spectrometry for Functional Cell/Developmental Biology

S39 - Richard Harland
Chromosome evolution in frogs

S40 - John Gurdon
A long transcription factor dwell time stabilizes cell differentiation

Poster Session

Thursday, 19 August 2021

Chair: Hazel Sive

PL05 - Marc Kirschner

S41 - Hajime Ogino
Morphological and behavioral characteristics of Xenopus tropicalis inbred strains in NBRP

S42 - Dom Alfandari
Production and Characterization of Monoclonal antibodies to Xenopus proteins

S43 - Esther Pearl
The Experimental Design Assistant: helping you design more rigorous in vivo experiments

S44 - Marko Horb
Xenopus Mutant Resource

S45 - Jacques Robert
Xenopus laevis Research Resource for Immunobiology (XLRRI): update and preparation for competing renewal in 2022

S46 - Matthew Guille
The EXRC: successful changes and unexpected challenges

Closing session & prize giving

Last Updated: 2021-09-10