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Summary Expression Phenotypes Gene Literature (677) GO Terms (3) Nucleotides (94) Proteins (51) Interactants (1024) Wiki
XB-GENEPAGE-485904

Papers associated with ins



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Xenopus pancreas development., Pearl EJ, Bilogan CK, Mukhi S, Brown DD, Horb ME., Dev Dyn. June 1, 2009; 238 (6): 1271-86.          


The tetraspanin Tm4sf3 is localized to the ventral pancreas and regulates fusion of the dorsal and ventral pancreatic buds., Jarikji Z, Horb LD, Shariff F, Mandato CA, Cho KW, Horb ME., Development. June 1, 2009; 136 (11): 1791-800.                  


Inhibition of insulin-stimulated hydrogen peroxide production prevents stimulation of sodium transport in A6 cell monolayers., Markadieu N, Crutzen R, Boom A, Erneux C, Beauwens R., Am J Physiol Renal Physiol. June 1, 2009; 296 (6): F1428-38.


Molecular and functional characterization of two distinct IGF binding protein-6 genes in zebrafish., Wang X, Lu L, Li Y, Li M, Chen C, Feng Q, Zhang C, Duan C., Am J Physiol Regul Integr Comp Physiol. May 1, 2009; 296 (5): R1348-57.


Remodeling of insulin producing beta-cells during Xenopus laevis metamorphosis., Mukhi S, Horb ME, Brown DD., Dev Biol. April 15, 2009; 328 (2): 384-91.          


Differential regulation of gonadotropins (FSH and LH) and growth hormone (GH) by neuroendocrine, endocrine, and paracrine factors in the zebrafish--an in vitro approach., Lin SW, Ge W., Gen Comp Endocrinol. January 15, 2009; 160 (2): 183-93.


Cytoplasmic polyadenylation-element-binding protein (CPEB)1 and 2 bind to the HIF-1alpha mRNA 3'-UTR and modulate HIF-1alpha protein expression., Hägele S, Kühn U, Böning M, Katschinski DM., Biochem J. January 1, 2009; 417 (1): 235-46.


Mechanism of disopyramide-induced hypoglycaemia in a patient with Type 2 diabetes., Negishi M, Shimomura K, Proks P, Mori M, Shimomura Y., Diabet Med. January 1, 2009; 26 (1): 76-8.


The orally active antihyperglycemic drug beta-guanidinopropionic acid is transported by the human proton-coupled amino acid transporter hPAT1., Metzner L, Dorn M, Markwardt F, Brandsch M., Mol Pharm. January 1, 2009; 6 (3): 1006-11.


Regulation of expression of zebrafish (Danio rerio) insulin-like growth factor 2 receptor: implications for evolution at the IGF2R locus., Tsalavouta M, Astudillo O, Byrnes L, Nolan CM., Evol Dev. January 1, 2009; 11 (5): 546-58.


Chicoric acid, a new compound able to enhance insulin release and glucose uptake., Tousch D, Lajoix AD, Hosy E, Azay-Milhau J, Ferrare K, Jahannault C, Cros G, Petit P., Biochem Biophys Res Commun. December 5, 2008; 377 (1): 131-5.


Activation and membrane binding of retinal protein kinase Balpha/Akt1 is regulated through light-dependent generation of phosphoinositides., Li G, Rajala A, Wiechmann AF, Anderson RE, Rajala RV., J Neurochem. December 1, 2008; 107 (5): 1382-97.


Regulation of pancreatic beta cell mass by neuronal signals from the liver., Imai J, Katagiri H, Yamada T, Ishigaki Y, Suzuki T, Kudo H, Uno K, Hasegawa Y, Gao J, Kaneko K, Ishihara H, Niijima A, Nakazato M, Asano T, Minokoshi Y, Oka Y., Science. November 21, 2008; 322 (5905): 1250-4.


Coassembly of different sulfonylurea receptor subtypes extends the phenotypic diversity of ATP-sensitive potassium (KATP) channels., Wheeler A, Wang C, Yang K, Fang K, Davis K, Styer AM, Mirshahi U, Moreau C, Revilloud J, Vivaudou M, Liu S, Mirshahi T, Chan KW., Mol Pharmacol. November 1, 2008; 74 (5): 1333-44.


Hypertrophy of mature Xenopus muscle fibres in culture induced by synergy of albumin and insulin., Jaspers RT, van Beek-Harmsen BJ, Blankenstein MA, Goldspink G, Huijing PA, van der Laarse WJ., Pflugers Arch. October 1, 2008; 457 (1): 161-70.


A novel, rapid, inhibitory effect of insulin on alpha1beta2gamma2s gamma-aminobutyric acid type A receptors., Williams DB., Neurosci Lett. September 26, 2008; 443 (1): 27-31.


IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis., Zhu W, Shiojima I, Ito Y, Li Z, Ikeda H, Yoshida M, Naito AT, Nishi J, Ueno H, Umezawa A, Minamino T, Nagai T, Kikuchi A, Asashima M, Komuro I., Nature. July 17, 2008; 454 (7202): 345-9.                        


Expression and regulation of HTRA1 during chick and early mouse development., Ferrer-Vaquer A, Maurey P, Werzowa J, Firnberg N, Leibbrandt A, Neubüser A., Dev Dyn. July 1, 2008; 237 (7): 1893-900.


Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo., Chiu SL, Chen CM, Cline HT., Neuron. June 12, 2008; 58 (5): 708-19.


Seeing the light: insulin receptors and the CNS., Needleman LA, McAllister AK., Neuron. June 12, 2008; 58 (5): 653-5.


A Kir6.2 mutation causing severe functional effects in vitro produces neonatal diabetes without the expected neurological complications., Tammaro P, Flanagan SE, Zadek B, Srinivasan S, Woodhead H, Hameed S, Klimes I, Hattersley AT, Ellard S, Ashcroft FM., Diabetologia. May 1, 2008; 51 (5): 802-10.            


Mitochondrial thioredoxin-2 from disk abalone (Haliotis discus discus): molecular characterization, tissue expression and DNA protection activity of its recombinant protein., De Zoysa M, Pushpamali WA, Whang I, Kim SJ, Lee J, Lee J., Comp Biochem Physiol B Biochem Mol Biol. April 1, 2008; 149 (4): 630-9.


The Gata5 target, TGIF2, defines the pancreatic region by modulating BMP signals within the endoderm., Spagnoli FM, Brivanlou AH., Development. February 1, 2008; 135 (3): 451-61.                                                    


Sulfonylurea receptors type 1 and 2A randomly assemble to form heteromeric KATP channels of mixed subunit composition., Chan KW, Wheeler A, Csanády L., J Gen Physiol. January 1, 2008; 131 (1): 43-58.                    


Site-specific phosphorylation of raf in cells containing oncogenic ras-p21 is likely mediated by jun-N-terminal kinase., Adler V, Bowne W, Michl J, Sookraj KA, Ikram K, Pestka S, Izotova L, Zenilman M, Friedman FK, Qu Y, Pincus MR., Ann Clin Lab Sci. January 1, 2008; 38 (1): 47-56.


Modulation of the voltage-gated potassium channel Kv1.5 by the SGK1 protein kinase involves inhibition of channel ubiquitination., Boehmer C, Laufer J, Jeyaraj S, Klaus F, Lindner R, Lang F, Palmada M., Cell Physiol Biochem. January 1, 2008; 22 (5-6): 591-600.


Chromatin opening and stable perturbation of core histone:DNA contacts by FoxO1., Hatta M, Cirillo LA., J Biol Chem. December 7, 2007; 282 (49): 35583-93.


The signal sequence coding region promotes nuclear export of mRNA., Palazzo AF, Springer M, Shibata Y, Lee CS, Lee CS, Dias AP, Rapoport TA., PLoS Biol. December 1, 2007; 5 (12): e322.              


Functional analysis of two Kir6.2 (KCNJ11) mutations, K170T and E322K, causing neonatal diabetes., Tarasov AI, Girard CA, Larkin B, Tammaro P, Flanagan SE, Ellard S, Ashcroft FM., Diabetes Obes Metab. November 1, 2007; 9 Suppl 2 46-55.


Nuclear localization of the ERK MAP kinase mediated by Drosophila alphaPS2betaPS integrin and importin-7., James BP, Bunch TA, Krishnamoorthy S, Perkins LA, Brower DL., Mol Biol Cell. October 1, 2007; 18 (10): 4190-9.


A novel mutation causing DEND syndrome: a treatable channelopathy of pancreas and brain., Shimomura K, Hörster F, de Wet H, Flanagan SE, Ellard S, Hattersley AT, Wolf NI, Ashcroft F, Ebinger F., Neurology. September 25, 2007; 69 (13): 1342-9.


The dual-specificity kinases, TOPK and DYRK1A, are critical for oocyte maturation induced by wild-type--but not by oncogenic--ras-p21 protein., Qu Y, Adler V, Izotova L, Pestka S, Bowne W, Michl J, Boutjdir M, Friedman FK, Pincus MR., Front Biosci. September 1, 2007; 12 5089-97.


Uncoupling by (--)-epigallocatechin-3-gallate of ATP-sensitive potassium channels from phosphatidylinositol polyphosphates and ATP., Jin JY, Park SH, Bae JH, Cho HC, Lim JG, Park WS, Han J, Lee JH, Song DK., Pharmacol Res. September 1, 2007; 56 (3): 237-47.


Iptakalim, a vascular ATP-sensitive potassium (KATP) channel opener, closes rat pancreatic beta-cell KATP channels and increases insulin release., Misaki N, Mao X, Lin YF, Suga S, Li GH, Liu Q, Chang Y, Wang H, Wakui M, Wu J., J Pharmacol Exp Ther. August 1, 2007; 322 (2): 871-8.


The secreted serine protease xHtrA1 stimulates long-range FGF signaling in the early Xenopus embryo., Hou S, Maccarana M, Min TH, Strate I, Pera EM., Dev Cell. August 1, 2007; 13 (2): 226-41.                      


Retinoic acid-mediated patterning of the pre-pancreatic endoderm in Xenopus operates via direct and indirect mechanisms., Pan FC, Chen Y, Chen Y, Bayha E, Pieler T., Mech Dev. August 1, 2007; 124 (7-8): 518-31.      


Role of SGK1 kinase in regulating glucose transport via glucose transporter GLUT4., Jeyaraj S, Boehmer C, Lang F, Palmada M., Biochem Biophys Res Commun. May 11, 2007; 356 (3): 629-35.


Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas., Jarikji ZH, Vanamala S, Beck CW, Wright CV, Leach SD, Horb ME., Dev Biol. April 15, 2007; 304 (2): 786-99.                


Transactivation of the IGF-1R by aldosterone., Holzman JL, Liu L, Duke BJ, Kemendy AE, Eaton DC., Am J Physiol Renal Physiol. April 1, 2007; 292 (4): F1219-28.


TALE-family homeodomain proteins regulate endodermal sonic hedgehog expression and pattern the anterior endoderm., diIorio P, Alexa K, Choe SK, Etheridge L, Sagerström CG., Dev Biol. April 1, 2007; 304 (1): 221-31.


PP2A:B56epsilon is required for eye induction and eye field separation., Rorick AM, Mei W, Liette NL, Phiel C, El-Hodiri HM, Yang J., Dev Biol. February 15, 2007; 302 (2): 477-93.                  


Characterization of the agr2 gene, a homologue of X. laevis anterior gradient 2, from the zebrafish, Danio rerio., Shih LJ, Lu YF, Chen YH, Lin CC, Chen JA, Hwang SP., Gene Expr Patterns. February 1, 2007; 7 (4): 452-60.                


Paxillin regulates steroid-triggered meiotic resumption in oocytes by enhancing an all-or-none positive feedback kinase loop., Rasar M, DeFranco DB, Hammes SR., J Biol Chem. December 22, 2006; 281 (51): 39455-64.              


Protein kinase B/Akt phosphorylation of PDE3A and its role in mammalian oocyte maturation., Han SJ, Vaccari S, Nedachi T, Andersen CB, Kovacina KS, Roth RA, Conti M., EMBO J. December 13, 2006; 25 (24): 5716-25.


Differential effects of muscle fibre length and insulin on muscle-specific mRNA content in isolated mature muscle fibres during long-term culture., Jaspers RT, Feenstra HM, van Beek-Harmsen BJ, Huijing PA, van der Laarse WJ., Cell Tissue Res. December 1, 2006; 326 (3): 795-808.


Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes., Girard CA, Shimomura K, Proks P, Absalom N, Castano L, Perez de Nanclares G, Ashcroft FM., Pflugers Arch. December 1, 2006; 453 (3): 323-32.


Expression analysis of IGFBP-rP10, IGFBP-like and Mig30 in early Xenopus development., Kuerner KM, Steinbeisser H., Dev Dyn. October 1, 2006; 235 (10): 2861-7.                                          


Two dual specificity kinases are preferentially induced by wild-type rather than by oncogenic RAS-P21 in Xenopus oocytes., Qu Y, Adler V, Chu T, Platica O, Michl J, Pestka S, Izotova L, Boutjdir M, Pincus MR., Front Biosci. September 1, 2006; 11 2420-7.


Target soluble N-ethylmaleimide-sensitive factor attachment protein receptors (t-SNAREs) differently regulate activation and inactivation gating of Kv2.2 and Kv2.1: Implications on pancreatic islet cell Kv channels., Wolf-Goldberg T, Michaelevski I, Sheu L, Gaisano HY, Chikvashvili D, Lotan I., Mol Pharmacol. September 1, 2006; 70 (3): 818-28.


Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations., Pearson ER, Flechtner I, Njølstad PR, Malecki MT, Flanagan SE, Larkin B, Ashcroft FM, Klimes I, Codner E, Iotova V, Slingerland AS, Shield J, Robert JJ, Holst JJ, Clark PM, Ellard S, Søvik O, Polak M, Hattersley AT, Neonatal Diabetes International Collaborative Group., N Engl J Med. August 3, 2006; 355 (5): 467-77.

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