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Summary Expression Phenotypes Gene Literature (677) GO Terms (3) Nucleotides (94) Proteins (51) Interactants (1024) Wiki
XB-GENEPAGE-485904

Papers associated with ins



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Combined ectopic expression of Pdx1 and Ptf1a/p48 results in the stable conversion of posterior endoderm into endocrine and exocrine pancreatic tissue., Afelik S, Chen Y, Pieler T., Genes Dev. June 1, 2006; 20 (11): 1441-6.                        

Functional effects of mutations at F35 in the NH2-terminus of Kir6.2 (KCNJ11), causing neonatal diabetes, and response to sulfonylurea therapy., Proks P, Girard C, Baevre H, Njølstad PR, Ashcroft FM., Diabetes. June 1, 2006; 55 (6): 1731-7.

GLUT8 is dispensable for embryonic development but influences hippocampal neurogenesis and heart function., Membrez M, Hummler E, Beermann F, Haefliger JA, Savioz R, Pedrazzini T, Thorens B., Mol Cell Biol. June 1, 2006; 26 (11): 4268-76.

Hormonal regulation of the epithelial Na+ channel: from amphibians to mammals., Shane MA, Nofziger C, Blazer-Yost BL., Gen Comp Endocrinol. May 15, 2006; 147 (1): 85-92.

The RNA-binding protein, Vg1RBP, is required for pancreatic fate specification., Spagnoli FM, Brivanlou AH., Dev Biol. April 15, 2006; 292 (2): 442-56.                      

A repeated IMP-binding motif controls oskar mRNA translation and anchoring independently of Drosophila melanogaster IMP., Munro TP, Kwon S, Schnapp BJ, St Johnston D., J Cell Biol. February 13, 2006; 172 (4): 577-88.              

SGK1 kinase upregulates GLUT1 activity and plasma membrane expression., Palmada M, Boehmer C, Akel A, Rajamanickam J, Jeyaraj S, Keller K, Lang F., Diabetes. February 1, 2006; 55 (2): 421-7.

Co-evolutionary analysis of insulin/insulin like growth factor 1 signal pathway in vertebrate species., Dou T, Ji C, Gu S, Xu J, Xu J, Ying K, Xie Y, Mao Y., Front Biosci. January 1, 2006; 11 380-8.

Characterization of taurine as inhibitor of sodium glucose transporter., Kim HW, Lee AJ, You S, Park T, Lee DH., Adv Exp Med Biol. January 1, 2006; 583 137-45.

PPARgamma agonists do not directly enhance basal or insulin-stimulated Na(+) transport via the epithelial Na(+) channel., Nofziger C, Chen L, Shane MA, Smith CD, Brown KK, Blazer-Yost BL., Pflugers Arch. December 1, 2005; 451 (3): 445-53.

Apparent receptor-mediated activation of Ca2+-dependent conductive Cl- transport by shark-derived polyaminosterols., Chernova MN, Vandorpe DH, Clark JS, Williams JI, Zasloff MA, Jiang L, Alper SL., Am J Physiol Regul Integr Comp Physiol. December 1, 2005; 289 (6): R1644-58.

Antagonistic interaction between IGF and Wnt/JNK signaling in convergent extension in Xenopus embryo., Carron C, Bourdelas A, Li HY, Boucaut JC, Shi DL., Mech Dev. November 1, 2005; 122 (11): 1234-47.                

Wnt5 signaling in vertebrate pancreas development., Kim HJ, Schleiffarth JR, Jessurun J, Sumanas S, Petryk A, Lin S, Ekker SC., BMC Biol. October 24, 2005; 3 23.                    

A rapid, nongenomic pathway facilitates the synaptic transmission induced by retinoic acid at the developing synapse., Liou JC, Ho SY, Shen MR, Liao YP, Chiu WT, Kang KH., J Cell Sci. October 15, 2005; 118 (Pt 20): 4721-30.

WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism., Xu BE, Stippec S, Lazrak A, Huang CL, Cobb MH., J Biol Chem. October 7, 2005; 280 (40): 34218-23.

Synergic action of insulin and genistein on Na+/K+/2Cl- cotransporter in renal epithelium., Ueda-Nishimura T, Niisato N, Miyazaki H, Naito Y, Yoshida N, Yoshikawa T, Nishino H, Marunaka Y., Biochem Biophys Res Commun. July 15, 2005; 332 (4): 1042-52.

Differential roles of p39Mos-Xp42Mpk1 cascade proteins on Raf1 phosphorylation and spindle morphogenesis in Xenopus oocytes., Bodart JF, Baert FY, Sellier C, Duesbery NS, Flament S, Vilain JP., Dev Biol. July 15, 2005; 283 (2): 373-83.

Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactions., Tammaro P, Girard C, Molnes J, Njølstad PR, Ashcroft FM., EMBO J. July 6, 2005; 24 (13): 2318-30.

NeuroD1 in the endocrine pancreas: localization and dual function as an activator and repressor., Itkin-Ansari P, Marcora E, Geron I, Tyrberg B, Demeterco C, Hao E, Padilla C, Ratineau C, Leiter A, Lee JE, Lee JE, Levine F., Dev Dyn. July 1, 2005; 233 (3): 946-53.

Glucocorticoid adrenal steroids and glucocorticoid-inducible kinase isoforms in the regulation of GluR6 expression., Strutz-Seebohm N, Seebohm G, Shumilina E, Mack AF, Wagner HJ, Lampert A, Grahammer F, Henke G, Just L, Skutella T, Hollmann M, Lang F., J Physiol. June 1, 2005; 565 (Pt 2): 391-401.

Hydrogen peroxide and epidermal growth factor activate phosphatidylinositol 3-kinase and increase sodium transport in A6 cell monolayers., Markadieu N, Crutzen R, Blero D, Erneux C, Beauwens R., Am J Physiol Renal Physiol. June 1, 2005; 288 (6): F1201-12.

The serine/threonine kinases SGK1, 3 and PKB stimulate the amino acid transporter ASCT2., Palmada M, Speil A, Jeyaraj S, Böhmer C, Lang F., Biochem Biophys Res Commun. May 27, 2005; 331 (1): 272-7.

Specificity of inhibition of ras-p21 signal transduction by peptides from GTPase activating protein (GAP) and the son-of sevenless (SOS) ras-specific guanine nucleotide exchange protein., Chie L, Chung D, Pincus MR., Protein J. May 1, 2005; 24 (4): 253-8.

Stichodactyla helianthus peptide, a pharmacological tool for studying Kv3.2 channels., Yan L, Herrington J, Goldberg E, Dulski PM, Bugianesi RM, Slaughter RS, Banerjee P, Brochu RM, Priest BT, Kaczorowski GJ, Rudy B, Garcia ML., Mol Pharmacol. May 1, 2005; 67 (5): 1513-21.

PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids., Goberdhan DC, Meredith D, Boyd CA, Wilson C., Development. May 1, 2005; 132 (10): 2365-75.

Sensitization and translocation of TRPV1 by insulin and IGF-I., Van Buren JJ, Bhat S, Rotello R, Pauza ME, Premkumar LS., Mol Pain. April 27, 2005; 1 17.        

Novel nucleotide-binding sites in ATP-sensitive potassium channels formed at gating interfaces., Dong K, Tang LQ, MacGregor GG, Leng Q, Hebert SC., EMBO J. April 6, 2005; 24 (7): 1318-29.

Context-dependent regulation of NeuroD activity and protein accumulation., Dufton C, Marcora E, Chae JH, McCullough J, Eby J, Hausburg M, Stein GH, Khoo S, Cobb MH, Lee JE, Lee JE., Mol Cell Neurosci. April 1, 2005; 28 (4): 727-36.

Serum- and glucocorticoid-inducible kinase 1 (SGK1) mediates glucocorticoid-induced inhibition of insulin secretion., Ullrich S, Berchtold S, Ranta F, Seebohm G, Henke G, Lupescu A, Mack AF, Chao CM, Su J, Nitschke R, Alexander D, Friedrich B, Wulff P, Kuhl D, Lang F., Diabetes. April 1, 2005; 54 (4): 1090-9.

Relapsing diabetes can result from moderately activating mutations in KCNJ11., Gloyn AL, Reimann F, Girard C, Edghill EL, Proks P, Pearson ER, Temple IK, Mackay DJ, Shield JP, Freedenberg D, Noyes K, Ellard S, Ashcroft FM, Gribble FM, Hattersley AT., Hum Mol Genet. April 1, 2005; 14 (7): 925-34.

Expression of porcine acid-labile subunit (pALS) of the 150-kilodalton ternary insulin-like growth factor complex and initial characterization of recombinant pALS protein., Lee DH, Chun C, Kim SH, Lee CY, Lee CY., J Biochem Mol Biol. March 31, 2005; 38 (2): 225-31.

Insulin facilitates the induction of the slow Na+ channels in immature Xenopus oocytes., Charpentier G., Gen Physiol Biophys. March 1, 2005; 24 (1): 57-73.

PKC site mutations reveal differential modulation by insulin of NMDA receptors containing NR2A or NR2B subunits., Jones ML, Leonard JP., J Neurochem. March 1, 2005; 92 (6): 1431-8.

Identification of two functional estrogen response elements complexed with AP-1-like sites in the human insulin receptor gene promoter., García-Arencibia M, Dávila N, Campión J, Carmen Carranza M, Calle C., J Steroid Biochem Mol Biol. February 1, 2005; 94 (1-3): 1-14.

Cofilin activity during insulin-like growth factor I-stimulated neuroblastoma cell motility., Meyer G, Kim B, van Golen C, Feldman EL., Cell Mol Life Sci. February 1, 2005; 62 (4): 461-70.

Modulation of basal and peptide hormone-stimulated Na transport by membrane cholesterol content in the A6 epithelial cell line., West A, Blazer-Yost B., Cell Physiol Biochem. January 1, 2005; 16 (4-6): 263-70.

Insulin-induced phosphorylation of ENaC correlates with increased sodium channel function in A6 cells., Zhang YH, Alvarez de la Rosa D, Canessa CM, Hayslett JP., Am J Physiol Cell Physiol. January 1, 2005; 288 (1): C141-7.

NeuroD: the predicted and the surprising., Chae JH, Stein GH, Lee JE, Lee JE., Mol Cells. December 31, 2004; 18 (3): 271-88.

A structural basis for the acute effects of HIV protease inhibitors on GLUT4 intrinsic activity., Hertel J, Struthers H, Horj CB, Hruz PW., J Biol Chem. December 31, 2004; 279 (53): 55147-52.

Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological features., Proks P, Antcliff JF, Lippiat J, Gloyn AL, Hattersley AT, Ashcroft FM., Proc Natl Acad Sci U S A. December 14, 2004; 101 (50): 17539-44.

Insulin-like growth factor (IGF) signalling is required for early dorso-anterior development of the zebrafish embryo., Eivers E, McCarthy K, Glynn C, Nolan CM, Byrnes L., Int J Dev Biol. December 1, 2004; 48 (10): 1131-40.

The FoxO-subclass in Xenopus laevis development., Pohl BS, Schön C, Rössner A, Knöchel W., Gene Expr Patterns. December 1, 2004; 5 (2): 187-92.    

Identification of a functionally important negatively charged residue within the second catalytic site of the SUR1 nucleotide-binding domains., Campbell JD, Proks P, Lippiat JD, Sansom MS, Ashcroft FM., Diabetes. December 1, 2004; 53 Suppl 3 S123-7.

Real-time three-dimensional imaging of lipid signal transduction: apical membrane insertion of epithelial Na(+) channels., Blazer-Yost BL, Vahle JC, Byars JM, Bacallao RL., Am J Physiol Cell Physiol. December 1, 2004; 287 (6): C1569-76.

Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis., Missiaglia E, Blaveri E, Terris B, Wang YH, Costello E, Neoptolemos JP, Crnogorac-Jurcevic T, Lemoine NR., Int J Cancer. October 20, 2004; 112 (1): 100-12.

Development of new anti-cancer peptides from conformational energy analysis of the oncogenic ras-p21 protein and its complexes with target proteins., Pincus MR., Front Biosci. September 1, 2004; 9 3486-509.

Differential regulation of islet-specific glucose-6-phosphatase catalytic subunit-related protein gene transcription by Pax-6 and Pdx-1., Martin CC, Oeser JK, O'Brien RM., J Biol Chem. August 13, 2004; 279 (33): 34277-89.

Functional characterization of an insulin-responsive glucose transporter (GLUT4) from fish adipose tissue., Capilla E, Díaz M, Albalat A, Navarro I, Pessin JE, Keller K, Planas JV., Am J Physiol Endocrinol Metab. August 1, 2004; 287 (2): E348-57.

Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release., Tagmose TM, Schou SC, Mogensen JP, Nielsen FE, Arkhammar PO, Wahl P, Hansen BS, Worsaae A, Boonen HC, Antoine MH, Lebrun P, Hansen JB., J Med Chem. June 3, 2004; 47 (12): 3202-11.

Metformin (Glucophage) inhibits tyrosine phosphatase activity to stimulate the insulin receptor tyrosine kinase., Holland W, Morrison T, Chang Y, Wiernsperger N, Stith BJ., Biochem Pharmacol. June 1, 2004; 67 (11): 2081-91.

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